Zobrazeno 1 - 10
of 206
pro vyhledávání: '"Michael A Brehm"'
Autor:
Ribhu Nayar, Elizabeth Schutten, Sonal Jangalwe, Philip A Durost, Laurie L Kenney, James M Conley, Keith Daniels, Michael A Brehm, Raymond M Welsh, Leslie J Berg
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144826 (2015)
CD8+ T cell exhaustion commonly occurs in chronic infections and cancers. During T cell exhaustion there is a progressive and hierarchical loss of effector cytokine production, up-regulation of inhibitory co-stimulatory molecules, and eventual deleti
Externí odkaz:
https://doaj.org/article/ad80a73d13c8499e95bd232a68ba7982
Autor:
Erica B Schleifman, Nicole Ali McNeer, Andrew Jackson, Jennifer Yamtich, Michael A Brehm, Leonard D Shultz, Dale L Greiner, Priti Kumar, W Mark Saltzman, Peter M Glazer
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)
Biodegradable poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) encapsulating triplex-forming peptide nucleic acids (PNAs) and donor DNAs for recombination-mediated editing of the CCR5 gene were synthesized for delivery into human peripheral
Externí odkaz:
https://doaj.org/article/9d231e9a17ac4b9681ad99bc3e340c3f
Autor:
Chaoxing Yang, Agata Jurczyk, Philip diIorio, Elaine Norowski, Michael A Brehm, Christian W Grant, Dennis L Guberski, Dale L Greiner, Rita Bortell
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78050 (2013)
Epidemiologic and clinical evidence suggests that virus infection plays an important role in human type 1 diabetes pathogenesis. We used the virus-inducible BioBreeding Diabetes Resistant (BBDR) rat to investigate the ability of sodium salicylate, a
Externí odkaz:
https://doaj.org/article/10866a00990e4432ba57fc70af044e2e
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15038 (2010)
The peripheral naïve T cell pool is comprised of a heterogeneous population of cells at various stages of development, which is a process that begins in the thymus and is completed after a post-thymic maturation phase in the periphery. One hallmark
Externí odkaz:
https://doaj.org/article/c94da60d198c4cc1a4c3642a011a5f4e
Autor:
Steven C Pino, Bryan O'Sullivan-Murphy, Erich A Lidstone, Chaoxing Yang, Kathryn L Lipson, Agata Jurczyk, Philip diIorio, Michael A Brehm, John P Mordes, Dale L Greiner, Aldo A Rossini, Rita Bortell
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5468 (2009)
Gimap5 (GTPase of the immunity-associated protein 5) has been linked to the regulation of T cell survival, and polymorphisms in the human GIMAP5 gene associate with autoimmune disorders. The BioBreeding diabetes-prone (BBDP) rat has a mutation in the
Externí odkaz:
https://doaj.org/article/b47c27fdea4649c3bca3dcc7d7cff892
Autor:
Taylor A. Stepien, Larissa A. Singletary, Fermin E. Guerra, Joyce E. Karlinsey, Stephen J. Libby, Sarah L. Jaslow, Margaret R. Gaggioli, Kyle D. Gibbs, Dennis C. Ko, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, Ferric C. Fang
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTSalmonella serovars Typhi and Paratyphi cause a prolonged illness known as enteric fever, whereas other serovars cause acute gastroenteritis. Mechanisms responsible for the divergent clinical manifestations of nontyphoidal and enteric fever S
Externí odkaz:
https://doaj.org/article/557b291ef5774526961df87681eb966d
Autor:
Dimpi Mukhopadhyay, Hira Lal Goel, Choua Xiong, Shivam Goel, Ayush Kumar, Rui Li, Lihua Julie Zhu, Jennifer L. Clark, Michael A. Brehm, Arthur M. Mercurio
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113347- (2023)
Summary: Understanding the cell biological mechanisms that enable tumor cells to persist after therapy is necessary to improve the treatment of recurrent disease. Here, we demonstrate that transient receptor potential channel 6 (TRPC6), a channel tha
Externí odkaz:
https://doaj.org/article/7444b6fcbf5240869afc18f3d3cac501
Autor:
Brian D. Stadinski, Sarah B. Cleveland, Michael A. Brehm, Dale L. Greiner, Priya G. Huseby, Eric S. Huseby
Publikováno v:
Nature Immunology. 24:652-663
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f7441516432253aa93fa2520bfe3585
https://doi.org/10.1038/s41590-023-01441-0
https://doi.org/10.1038/s41590-023-01441-0
Autor:
Jane Chuprin, Hannah Buettner, Mina O. Seedhom, Dale L. Greiner, James G. Keck, Fumihiko Ishikawa, Leonard D. Shultz, Michael A. Brehm
Publikováno v:
Nature Reviews Clinical Oncology. 20:192-206
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7cba2cc146732463cb5c6d8cd183330
https://doi.org/10.1038/s41571-022-00721-2
https://doi.org/10.1038/s41571-022-00721-2
Publikováno v:
Journal of Leukocyte Biology. 113:418-433
Agents that induce inflammation have been used since the 18th century for the treatment of cancer. The inflammation induced by agents such as Toll-like receptor agonists is thought to stimulate tumor-specific immunity in patients and augment control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c50803df8ca4e8272ef6bf70f138b871
https://doi.org/10.1093/jleuko/qiac020
https://doi.org/10.1093/jleuko/qiac020