Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Michael A Bachman"'
Autor:
Harry L T Mobley, Mark T Anderson, Bridget S Moricz, Geoffrey B Severin, Caitlyn L Holmes, Elizabeth N Ottosen, Tad Eichler, Surbhi Gupta, Santosh Paudel, Ritam Sinha, Sophia Mason, Stephanie D Himpsl, Aric N Brown, Margaret Gaca, Christina M Kiser, Thomas H Clarke, Derrick E Fouts, Victor J DiRita, Michael A Bachman
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012495 (2024)
There is a critical gap in knowledge about how Gram-negative bacterial pathogens, using survival strategies developed for other niches, cause lethal bacteremia. Facultative anaerobic species of the Enterobacterales order are the most common cause of
Externí odkaz:
https://doaj.org/article/790cb40716724b9980c96102427a6fde
Autor:
Jay Vornhagen, Christine M Bassis, Srividya Ramakrishnan, Robert Hein, Sophia Mason, Yehudit Bergman, Nicole Sunshine, Yunfan Fan, Caitlyn L Holmes, Winston Timp, Michael C Schatz, Vincent B Young, Patricia J Simner, Michael A Bachman
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009537 (2021)
Klebsiella pneumoniae (Kp) is an important cause of healthcare-associated infections, which increases patient morbidity, mortality, and hospitalization costs. Gut colonization by Kp is consistently associated with subsequent Kp disease, and patients
Externí odkaz:
https://doaj.org/article/fa3d3e515da74a689ac27b6245f842d6
Autor:
Laura A Mike, Andrew J Stark, Valerie S Forsyth, Jay Vornhagen, Sara N Smith, Michael A Bachman, Harry L T Mobley
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009376 (2021)
Hypervirulent K. pneumoniae (hvKp) is a distinct pathotype that causes invasive community-acquired infections in healthy individuals. Hypermucoviscosity (hmv) is a major phenotype associated with hvKp characterized by copious capsule production and p
Externí odkaz:
https://doaj.org/article/9c527e2000c44b9c93b2cdaf8183b5c6
Autor:
Jay Vornhagen, Yuang Sun, Paul Breen, Valerie Forsyth, Lili Zhao, Harry L T Mobley, Michael A Bachman
Publikováno v:
PLoS Pathogens, Vol 15, Iss 8, p e1008010 (2019)
Klebsiella pneumoniae (Kp), one of the most common causes of healthcare-associated infections, increases patient morbidity, mortality, and hospitalization costs. Kp must acquire nutrients from the host for successful infection; however, the host is a
Externí odkaz:
https://doaj.org/article/a36a514dc4da4de5afb137ec3baa90d1
Autor:
Chelsie E Armbruster, Valerie S Forsyth, Alexandra O Johnson, Sara N Smith, Ashley N White, Aimee L Brauer, Brian S Learman, Lili Zhao, Weisheng Wu, Mark T Anderson, Michael A Bachman, Harry L T Mobley
Publikováno v:
PLoS Pathogens, Vol 15, Iss 4, p e1007653 (2019)
The Gram-negative bacterium Proteus mirabilis is a common cause of catheter-associated urinary tract infections (CAUTI), which can progress to secondary bacteremia. While numerous studies have investigated experimental infection with P. mirabilis in
Externí odkaz:
https://doaj.org/article/3b1cfff69ee54e98a7399e8f7df5af4c
Publikováno v:
PLoS Pathogens, Vol 5, Iss 10, p e1000622 (2009)
Nasal colonization by both gram-positive and gram-negative pathogens induces expression of the innate immune protein lipocalin 2 (Lcn2). Lcn2 binds and sequesters the iron-scavenging siderophore enterobactin (Ent), preventing bacterial iron acquisiti
Externí odkaz:
https://doaj.org/article/bbec7700953b4be8b18d52402e3cdace
Publikováno v:
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-11 (2017)
Abstract Background Tn-Seq is a high throughput technique for analysis of transposon mutant libraries to determine conditional essentiality of a gene under an experimental condition. A special feature of the Tn-seq data is that multiple mutants in a
Externí odkaz:
https://doaj.org/article/76271d75ce674e8d8ed101edd2015f87
Publikováno v:
medRxiv
The primary risk factor for infection with members ofthe Klebsiella pneumoniaespecies complex is prior gut colonization, and infection is often caused by the colonizing strain. Despite the importance of the gut as a reservoir for infectiousKlebsiella
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9ca56b45f037f30e2ede34b3200a6e
https://doi.org/10.1101/2023.04.18.23288742
https://doi.org/10.1101/2023.04.18.23288742
Bacteremia, a systemic infection associated with severe clinical outcomes, is often caused by Gram-negative facultative anaerobes. ArcAB, a two-component regulatory system that represses aerobic respiration, is a key mediator of metabolic adaptation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2da3d38c9398007cd58d08bcdabbc372
https://doi.org/10.1101/2023.04.18.537286
https://doi.org/10.1101/2023.04.18.537286
Autor:
Caitlyn L. Holmes, Alexis E. Wilcox, Valerie Forsyth, Sara N. Smith, Bridget S. Moricz, Lavinia V. Unverdorben, Sophia Mason, Weisheng Wu, Lili Zhao, Harry L.T. Mobley, Michael A. Bachman
Gram-negative bacteremia is a major cause of global morbidity involving three phases of pathogenesis: initial site infection, dissemination, and survival in the blood and filtering organs.Klebsiella pneumoniaeis a leading cause of bacteremia and pneu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc723ee519b03c7c99766f1c5a4e095e
https://doi.org/10.1101/2023.02.23.529827
https://doi.org/10.1101/2023.02.23.529827