Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Michael A, Trakselis"'
Autor:
Wezley C. Griffin, David R. McKinzey, Kathleen N. Klinzing, Rithvik Baratam, Achini Eliyapura, Michael A. Trakselis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The MCM8/9 helicase has been implicated in DNA recombination processes with mutations in these genes causative for infertility and cancer. Here, the authors show that MCM8/9 aids normal fork progression and also stabilizes persistently stalled forks,
Externí odkaz:
https://doaj.org/article/b065c20a999744f3b6317e6f71efc98a
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2022)
High fidelity (HiFi) DNA polymerases (Pols) perform the bulk of DNA synthesis required to duplicate genomes in all forms of life. Their structural features, enzymatic mechanisms, and inherent properties are well-described over several decades of rese
Externí odkaz:
https://doaj.org/article/4e23ade6ce6343a9a2dfecc5b8ddfc03
Autor:
Megan S Behrmann, Himasha M Perera, Joy M Hoang, Trisha A Venkat, Bryan J Visser, David Bates, Michael A Trakselis
Publikováno v:
PLoS Genetics, Vol 17, Iss 11, p e1009886 (2021)
Helicase regulation involves modulation of unwinding speed to maintain coordination of DNA replication fork activities and is vital for replisome progression. Currently, mechanisms for helicase regulation that involve interactions with both DNA stran
Externí odkaz:
https://doaj.org/article/77aee7d7231e48be89bb2d4a92f4466a
Autor:
Michael A. Trakselis, Himasha M Perera
Publikováno v:
Methods. 204:160-171
Helicase enzymes translocate along an RNA or DNA template with a defined polarity to unwind, separate, or remodel duplex strands for a variety of genome maintenance processes. Helicase mutations are commonly associated with a variety of diseases incl
Autor:
Himasha M Perera, Michael A Trakselis
Publikováno v:
eLife, Vol 8 (2019)
DNA replication requires that the duplex genomic DNA strands be separated; a function that is implemented by ring-shaped hexameric helicases in all Domains. Helicases are composed of two domains, an N- terminal DNA binding domain (NTD) and a C- termi
Externí odkaz:
https://doaj.org/article/3098a9dfb6ec42d1a806f5e95703de84
Publikováno v:
Methods in enzymology. 672
The genome of prokaryotes can be damaged by a variety of endogenous and exogenous factors, including reactive oxygen species, UV exposure, and antibiotics. To better understand these repair processes and the impact they may have on DNA replication, n
Autor:
Michael A. Trakselis
Publikováno v:
F1000Research, Vol 5 (2016)
Hexameric helicases control both the initiation and the elongation phase of DNA replication. The toroidal structure of these enzymes provides an inherent challenge in the opening and loading onto DNA at origins, as well as the conformational changes
Externí odkaz:
https://doaj.org/article/4389b3d6e4f5490f8cc663f3f7a36627
Autor:
Michael A, Trakselis
Publikováno v:
Methods in Enzymology ISBN: 9780323914765
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2161ea66a7aceaea9ee3869633c2f071
https://doi.org/10.1016/s0076-6879(22)00284-1
https://doi.org/10.1016/s0076-6879(22)00284-1
Autor:
Wezley C. Griffin, David R. McKinzey, Kathleen N. Klinzing, Rithvik Baratam, Michael A. Trakselis
The minichromosome maintenance (MCM) 8/9 helicase is a AAA+ complex involved in DNA replication-associated repair. Despite high sequence homology to the MCM2-7 helicase, an active role for MCM8/9 has remained elusive. We interrogated fork progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::946417fc44df69538c31400d8c22ef89
https://doi.org/10.1101/2021.12.08.471807
https://doi.org/10.1101/2021.12.08.471807
Autor:
Wezley C. Griffin, David R. McKinzey, Kathleen N. Klinzing, Rithvik Baratam, Achini Eliyapura, Michael A. Trakselis
Publikováno v:
Nature communications. 13(1)
The minichromosome maintenance (MCM) 8/9 helicase is a AAA+ complex involved in DNA replication-associated repair. Despite high sequence homology to the MCM2-7 helicase, a precise cellular role for MCM8/9 has remained elusive. We have interrogated th