Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Michael A, Purdy"'
Autor:
Susan A. Leonhardt, Michael D. Purdy, Jonathan R. Grover, Ziwei Yang, Sandra Poulos, William E. McIntire, Elizabeth A. Tatham, Satchal K. Erramilli, Kamil Nosol, Kin Kui Lai, Shilei Ding, Maolin Lu, Pradeep D. Uchil, Andrés Finzi, Alan Rein, Anthony A. Kossiakoff, Walther Mothes, Mark Yeager
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The host proteins SERINC3 and SERINC5 are HIV-1 restriction factors that reduce infectivity when incorporated into the viral envelope. The HIV-1 accessory protein Nef abrogates incorporation of SERINCs via binding to intracellular loop 4 (IC
Externí odkaz:
https://doaj.org/article/b42d4618236b4cabb367d4bb3ff2f26d
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract B1 cell-derived natural antibodies are non-specific polyreactive antibodies and can activate the complement pathway leading to lysis of enveloped virus particles before activation of the adaptive immune response. We investigated the relation
Externí odkaz:
https://doaj.org/article/98980d6e890f4affb60ea9d3b1de56e2
Publikováno v:
Life, Vol 13, Iss 7, p 1527 (2023)
The hepatitis B virus (HBV) and hepatitis D virus (HDV) infections cause liver disease, including hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). HBV infection remains a major global health problem. In 2019, 296 million people were living w
Externí odkaz:
https://doaj.org/article/61bec4c113bc45e787bad79c85e6af35
Autor:
Somnath Mukherjee, Satchal K. Erramilli, Mark Ammirati, Frances J. D. Alvarez, Kimberly F. Fennell, Michael D. Purdy, Blazej M. Skrobek, Katarzyna Radziwon, John Coukos, Yanyong Kang, Przemysław Dutka, Xiang Gao, Xiayang Qiu, Mark Yeager, H. Eric Xu, Seungil Han, Anthony A. Kossiakoff
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Single particle cryo-electron microscopy of membrane proteins is limited by their small size and difficulty to orient. Here the authors generate recombinant antibodies against the 12 kDa fusion partner BRIL domain from apocytochrome b562 to use them
Externí odkaz:
https://doaj.org/article/c4e601bd5c28456ba07689558d4667e5
Publikováno v:
Virology Journal, Vol 16, Iss 1, Pp 1-10 (2019)
Abstract Background Avian hepatitis E virus (aHEV) has been associated with hepatitis-splenomegaly syndrome (HSS) in chickens along with asymptomatic subclinical infection in many cases. So far, four genotypes have been described, which cause infecti
Externí odkaz:
https://doaj.org/article/532cbafe21d845bdbb3fd79777b93ed1
Autor:
Ali K. Khan, Maciej Jagielnicki, William E. McIntire, Michael D. Purdy, Venkatasubramanian Dharmarajan, Patrick R. Griffin, Mark Yeager
Publikováno v:
Cell Reports, Vol 31, Iss 3, Pp - (2020)
Summary: Gap junction channels (GJCs) mediate intercellular communication and are gated by numerous conditions such as pH. The electron cryomicroscopy (cryo-EM) structure of Cx26 GJC at physiological pH recapitulates previous GJC structures in lipid
Externí odkaz:
https://doaj.org/article/d163253f30b04e81a04f624ad4d3420b
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0237618 (2020)
Hepatitis E virus (HEV) genotype 1 (gt1) and gt3 infections have distinct epidemiologic characteristics and genotype-specific molecular mechanisms of pathogenesis are not well characterized. Previously, we showed differences in immune response-relate
Externí odkaz:
https://doaj.org/article/855c9dc41c464433ae0112d5a40cfa60
Autor:
Youkyung Choi, Grace Sanghee Lee, Song Li, Jeong Woo Lee, Tonya Mixson-Hayden, Jungreem Woo, Dengning Xia, Mark R. Prausnitz, Saleem Kamili, Michael A. Purdy, Rania A. Tohme
Publikováno v:
Vaccine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd919e8b9e749cb62ea27eb68cedbed7
https://doi.org/10.1016/j.vaccine.2023.05.005
https://doi.org/10.1016/j.vaccine.2023.05.005
Autor:
Brad C. Bennett, Michael D. Purdy, Kent A. Baker, Chayan Acharya, William E. McIntire, Raymond C. Stevens, Qinghai Zhang, Andrew L. Harris, Ruben Abagyan, Mark Yeager
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Intercellular signalling can be mediated by gap junction channels, and calcium blocks this signally during tissue injury. Here, the authors use X-ray crystallography and molecular dynamics to show that the calcium forms an electrostatic barrier to pr
Externí odkaz:
https://doaj.org/article/8711c8402a1e467da4c3721f1fe65a53
Autor:
Michael A, Purdy, Jan Felix, Drexler, Xiang-Jin, Meng, Heléne, Norder, Hiroaki, Okamoto, Wim H M, Van der Poel, Gábor, Reuter, William M, de Souza, Rainer G, Ulrich, Donald B, Smith
Publikováno v:
The Journal of general virology. 103(9)
The family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bfd75913b7bdeece3beb693622ef6832
https://pubmed.ncbi.nlm.nih.gov/36170152
https://pubmed.ncbi.nlm.nih.gov/36170152