Zobrazeno 1 - 10
of 242
pro vyhledávání: '"Michael A, Palladino"'
Autor:
Tracey D. Myers, Yizhi Li, Stefanie Taiclet, Paulina Cabada-Aguirre, Emily Kuti, Kaitlin McClure, Christopher Blanchard, Marta Wolosowicz, Gregg E. Homanics, Adam C. Straub, Stephen D. Meriney, Michael J. Palladino
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Triosephosphate isomerase deficiency (TPI Df) is a rare multisystem disorder with severe neuromuscular symptoms which arises exclusively from mutations within the TPI1 gene. Studies of TPI Df have been limited due to the absence of mammalian
Externí odkaz:
https://doaj.org/article/cadf9011a35d4760a00e26990a31124a
Autor:
Tracey D. Myers, Michael J. Palladino
Publikováno v:
Molecular Medicine, Vol 29, Iss 1, Pp 1-6 (2023)
Abstract Triosephosphate isomerase (TPI) is best known as a glycolytic enzyme that interconverts the 3-carbon sugars dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (G3P). TPI is an essential enzyme that is required for the catabolis
Externí odkaz:
https://doaj.org/article/502a1e099bdd4a54994f58c3bbedb07f
Autor:
Andrew P. VanDemark, Stacy L. Hrizo, Samantha L. Eicher, Jules Kowalski, Tracey D. Myers, Megan R. Pfeifer, Kacie N. Riley, Dwight D. Koeberl, Michael J. Palladino
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 5 (2022)
Triosephosphate isomerase (TPI) deficiency (TPI Df) is an untreatable glycolytic enzymopathy that results in hemolytic anemia, progressive muscular impairment and irreversible brain damage. Although there is a ‘common’ mutation (TPIE105D), other
Externí odkaz:
https://doaj.org/article/6e587810fc2644ddac6db38219dae764
Publikováno v:
Current Research in Neurobiology, Vol 3, Iss , Pp 100062- (2022)
Triosephosphate isomerase deficiency (TPI Df) is a rare, aggressive genetic disease that typically affects young children and currently has no established treatment. TPI Df is characterized by hemolytic anemia, progressive neuromuscular degeneration,
Externí odkaz:
https://doaj.org/article/79c5ac5e12ca420ca08778d42c2affb9
Publikováno v:
Neurobiology of Sleep and Circadian Rhythms, Vol 6, Iss , Pp 44-52 (2019)
Mitochondrial encephalomyopathies (ME) are complex, incurable diseases characterized by severe bioenergetic distress that can affect the function of all major organ systems but is especially taxing to neuromuscular tissues. Animal models of MEs are r
Externí odkaz:
https://doaj.org/article/7db58bf40eba48239960717e95fb30e3
Autor:
Stacy L. Hrizo, Samantha L. Eicher, Tracey D. Myers, Ian McGrath, Andrew P.K. Wodrich, Hemanth Venkatesh, Daniel Manjooran, Sabrina Swoger, Kim Gagnon, Matthew Bruskin, Maria V. Lebedev, Sherry Zheng, Ana Vitantonio, Sungyoun Kim, Zachary J. Lamb, Andreas Vogt, Maura R.Z. Ruzhnikov, Michael J. Palladino
Publikováno v:
Neurobiology of Disease, Vol 152, Iss , Pp 105299- (2021)
Triosephosphate isomerase (TPI) deficiency (Df) is a rare recessive metabolic disorder that manifests as hemolytic anemia, locomotor impairment, and progressive neurodegeneration. Research suggests that TPI Df mutations, including the “common” TP
Externí odkaz:
https://doaj.org/article/40387faf9837432e845ed51feb7d8d99
Autor:
Kevin G. Hicks, Ahmad A. Cluntun, Heidi L. Schubert, Sean R. Hackett, Jordan A. Berg, Paul G. Leonard, Mariana A. Ajalla Aleixo, Youjia Zhou, Alex J. Bott, Sonia R. Salvatore, Fei Chang, Aubrie Blevins, Paige Barta, Samantha Tilley, Aaron Leifer, Andrea Guzman, Ajak Arok, Sarah Fogarty, Jacob M. Winter, Hee-Chul Ahn, Karen N. Allen, Samuel Block, Iara A. Cardoso, Jianping Ding, Ingrid Dreveny, William C. Gasper, Quinn Ho, Atsushi Matsuura, Michael J. Palladino, Sabin Prajapati, Pengkai Sun, Kai Tittmann, Dean R. Tolan, Judith Unterlass, Andrew P. VanDemark, Matthew G. Vander Heiden, Bradley A. Webb, Cai-Hong Yun, Pengkai Zhao, Bei Wang, Francisco J. Schopfer, Christopher P. Hill, Maria Cristina Nonato, Florian L. Muller, James E. Cox, Jared Rutter
Publikováno v:
Science
Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352755dceffe88559d81ce00a2f38a1e
https://doi.org/10.1126/science.abm3452
https://doi.org/10.1126/science.abm3452
Autor:
Kenneth W. Drombosky, Sascha Rode, Ravi Kodali, Tija C. Jacob, Michael J. Palladino, Ronald Wetzel
Publikováno v:
Neurobiology of Disease, Vol 120, Iss , Pp 126-138 (2018)
In Huntington disease (HD), an expanded polyglutamine (polyQ > 37) sequence within huntingtin (htt) exon1 leads to enhanced disease risk. It has proved difficult, however, to determine whether the toxic form generated by polyQ expansion is a misfolde
Externí odkaz:
https://doaj.org/article/9884ce11e91d4fe08225fe51b3471656
Publikováno v:
Basic and Clinical Andrology, Vol 28, Iss 1, Pp 1-12 (2018)
Résumé Contexte L’infection et l’inflammation bactériennes du testicule altèrent la fertilité; cependant la compréhension des réponses inflammatoires du testicule est. encore incomplète. Nous nous sommes intéressés à l’identification
Externí odkaz:
https://doaj.org/article/6721546543d641b8ab29cdca4b07b0db
Autor:
Desiree M. Markantone, Atif Towheed, Aaron T. Crain, Jessica M. Collins, Alicia M. Celotto, Michael J. Palladino
Publikováno v:
Neurobiology of Disease, Vol 117, Iss , Pp 203-210 (2018)
Mitochondrial encephalomyopathies (MEs) result from mutations in mitochondrial genes critical to oxidative phosphorylation. Severe and untreatable ME results from mutations affecting each endogenous mitochondrial encoded gene, including all 13 establ
Externí odkaz:
https://doaj.org/article/1d7b2d5169c747a2b77b765c85e314f5