Zobrazeno 1 - 10
of 1 121
pro vyhledávání: '"Michael A, Matthay"'
Autor:
Camille R. Simoneau, Pei-Yi Chen, Galen K. Xing, Jennifer M. Hayashi, Irene P. Chen, Mir M. Khalid, Nathan L. Meyers, Taha Y. Taha, Kristoffer E. Leon, Rahul K. Suryawanshi, Maria McCavitt-Malvido, Tal Ashuach, Krystal A. Fontaine, Lauren Rodriguez, Bastian Joehnk, Keith Walcott, Sreelakshmi Vasudevan, Xiaohui Fang, Mazharul Maishan, Shawn Schultz, Jeroen P. Roose, Michael A. Matthay, Anita Sil, Mehrdad Arjomandi, Nir Yosef, Melanie Ott
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract As SARS-CoV-2 continues to spread worldwide, tractable primary airway cell models that recapitulate the cell-intrinsic response to arising viral variants are needed. Here we describe an adult stem cell-derived human airway organoid model ove
Externí odkaz:
https://doaj.org/article/2b9300e935d0405aa6dbdcaf44fa0f99
Autor:
Rahul Y. Mahida, Zhengqiang Yuan, Krishna K. Kolluri, Aaron Scott, Dhruv Parekh, Rowan S. Hardy, Michael A. Matthay, Gavin D. Perkins, Sam M. Janes, David R. Thickett
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
BackgroundHuman bone marrow mesenchymal stem cell (MSC) administration reduces inflammation in pre-clinical models of sepsis and sepsis-related lung injury, however clinical efficacy in patients has not yet been demonstrated. We previously showed tha
Externí odkaz:
https://doaj.org/article/0f8693c2f31c4a3599fce5ef594f00f9
Autor:
Victoria T. Chu, Alexandra Tsitsiklis, Eran Mick, Lilliam Ambroggio, Katrina L. Kalantar, Abigail Glascock, Christina M. Osborne, Brandie D. Wagner, Michael A. Matthay, Joseph L. DeRisi, Carolyn S. Calfee, Peter M. Mourani, Charles R. Langelier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Antimicrobial resistant lower respiratory tract infections are an increasing public health threat and an important cause of global mortality. The lung microbiome can influence susceptibility of respiratory tract infections and represents an
Externí odkaz:
https://doaj.org/article/a6e6c725bdd94596848389ca69371515
Autor:
Priya A. Prasad, Armond M. Esmaili, Sandra Oreper, Alexander J. Beagle, Colin Hubbard, Katie E. Raffel, Yumiko Abe‐Jones, Margaret C. Fang, Kathleen D. Liu, Michael A. Matthay, Kirsten N. Kangelaris
Publikováno v:
Journal of the American College of Emergency Physicians Open, Vol 5, Iss 2, Pp n/a-n/a (2024)
Abstract Objective Recent clinical guidelines for sepsis management emphasize immediate antibiotic initiation for suspected septic shock. Though hypotension is a high‐risk marker of sepsis severity, prior studies have not considered the precise tim
Externí odkaz:
https://doaj.org/article/70408a87ce314437af9f47ed25a64b37
Autor:
Carrie M. Rosenberger, Katherine D. Wick, Hanjing Zhuo, Nelson Wu, Yue Chen, Sharookh B. Kapadia, Alessander Guimaraes, Diana Chang, David F. Choy, Hubert Chen, Melicent Peck, Kathryn M. Sullivan, Serena Ke, Alejandra Jauregui, Aleksandra Leligdowicz, Pratik Sinha, Antonio D. Gomez, Kirsten N. Kangelaris, Kevin Delucchi, Kathleen D. Liu, Carolyn S. Calfee, Michael A. Matthay, Carolyn M. Hendrickson
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-4 (2023)
Abstract Angiopoietin-2 (Ang-2) is associated with vascular endothelial injury and permeability in the acute respiratory distress syndrome (ARDS) and sepsis. Elevated circulating Ang-2 levels may identify critically ill patients with distinct pathobi
Externí odkaz:
https://doaj.org/article/bb55343a042743f580ac39a049bd0386
Autor:
Shaun M. Pienkos, Andrew R. Moore, Jiazhen Guan, Joseph E. Levitt, Michael A. Matthay, Rebecca M. Baron, John Conlon, Daniel F. McAuley, Cecilia M. O’Kane, Angela J. Rogers
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-9 (2023)
Abstract Background Two acute respiratory distress syndrome (ARDS) trials showed no benefit for statin therapy, though secondary analyses suggest inflammatory subphenotypes may have a differential response to simvastatin. Statin medications decrease
Externí odkaz:
https://doaj.org/article/65d6714ebc4c4cc289e1fce88f12a77f
Autor:
Asawari Korde, Maria Haslip, Prachi Pednekar, Alamzeb Khan, Maurizio Chioccioli, Sameet Mehta, Francesc Lopez-Giraldez, Santos Bermejo, Mauricio Rojas, Charles Dela Cruz, Michael A. Matthay, Jordan S. Pober, Richard W. Pierce, Shervin S. Takyar
Publikováno v:
JCI Insight, Vol 8, Iss 18 (2023)
Acute lung injury (ALI) and its most severe form, acute respiratory distress syndrome (ARDS), cause severe endothelial dysfunction in the lung, and vascular endothelial growth factor (VEGF) is elevated in ARDS. We found that the levels of a VEGF-regu
Externí odkaz:
https://doaj.org/article/ebda4adf73f34110a81a0dc129c0b9de
Autor:
Christian M. Jensen, Junia C. Costa, Jens C. Nørgaard, Adrian G. Zucco, Bastian Neesgaard, Carsten U. Niemann, Sisse R. Ostrowski, Joanne Reekie, Birgit Holten, Anna Kalhauge, Michael A. Matthay, Jens D. Lundgren, Marie Helleberg, Kasper S. Moestrup
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Spatial resolution in existing chest x-ray (CXR)-based scoring systems for coronavirus disease 2019 (COVID-19) pneumonia is low, and should be increased for better representation of anatomy, and severity of lung involvement. An existing CXR-
Externí odkaz:
https://doaj.org/article/c6143a3479414b7992a3b36d75b64546
Autor:
Katherine D. Wick, Aleksandra Leligdowicz, Andrew Willmore, Sidney A. Carrillo, Rajani Ghale, Alejandra Jauregui, Suzanna S. Chak, Viet Nguyen, Deanna Lee, Chayse Jones, Robin Dewar, H. Clifford Lane, Kirsten N. Kangelaris, Carolyn M. Hendrickson, Kathleen D. Liu, Pratik Sinha, David J. Erle, Charles R. Langelier, Matthew F. Krummell, Prescott G. Woodruff, Carolyn S. Calfee, Michael A. Matthay, the COMET Consortium
Publikováno v:
Critical Care, Vol 26, Iss 1, Pp 1-11 (2022)
Abstract Background Studies quantifying SARS-CoV-2 have focused on upper respiratory tract or plasma viral RNA with inconsistent association with clinical outcomes. The association between plasma viral antigen levels and clinical outcomes has not bee
Externí odkaz:
https://doaj.org/article/e599ea26c99e4e01a0e78f4b33fff553
Autor:
Ana Carolina Costa Monteiro, Sitaram Vangala, Katherine D. Wick, Kevin L. Delucchi, Emily R. Siegel, B. Taylor Thompson, Kathleen D. Liu, Anil Sapru, Pratik Sinha, Michael A. Matthay, NHLBI PETAL Network
Publikováno v:
Critical Care, Vol 26, Iss 1, Pp 1-9 (2022)
Abstract Background The ventilatory ratio (VR, [minute ventilation × PaCO2]/[predicted body weight × 100 × 37.5]) is associated with mortality in ARDS. The aims of this study were to test whether baseline disease severity or neuromuscular blockade
Externí odkaz:
https://doaj.org/article/19f3704a2d004416a414bfc4c2694a08