A high‐affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain

Autor: Nikolaj R Christensen, Marta De Luca, Michael B Lever, Mette Richner, Astrid B Hansen, Gith Noes‐Holt, Kathrine L Jensen, Mette Rathje, Dennis Bo Jensen, Simon Erlendsson, Christian RO Bartling, Ina Ammendrup‐Johnsen, Sofie E Pedersen, Michèle Schönauer, Klaus B Nissen, Søren R Midtgaard, Kaare Teilum, Lise Arleth, Andreas T Sørensen, Anders Bach, Kristian Strømgaard, Claire F Meehan, Christian B Vægter, Ulrik Gether, Kenneth L Madsen

Publikováno v: EMBO Molecular Medicine, Vol 12, Iss 6, Pp 1-25 (2020)

Abstract Maladaptive plasticity involving increased expression of AMPA‐type glutamate receptors is involved in several pathologies, including neuropathic pain, but direct inhibition of AMPARs is associated with side effects. As an alternative, we d

Externí odkaz: https://doaj.org/article/8a1820f6df8d4578a98d525b18b57606

The Northern Likes: The Case of Northwest Territories’ Social Media Campaign

Autor: Michael W. Lever, Statia Elliot

Externí odkaz: https://sk.sagepub.com/cases/the-northern-likes-northwest-territories-social-media-campaign

Comparative study of the analysis of seized samples by GC-MS, 1H NMR and FT-IR spectroscopy within a Night-Time Economy (NTE) setting

Autor: David I. Dixon, Lysbeth H. Antonides, Andrew Costello, Benjamin Crane, Arran Embleton, Mark L. Fletcher, Nicolas Gilbert, Matthew C. Hulme, Molly J. James, Michael A. Lever, Conner J. Maccallum, Molly F. Millea, Jessica L. Pimlott, Thomas B.R. Robertson, Nathan E. Rudge, Christopher J. Schofield, Filip Zukowicz, E. Kate Kemsley, Oliver B. Sutcliffe, Ryan E. Mewis

Rapid analysis of surrendered or seized drug samples provides important intelligence for health (e.g. treatment or harm reduction), and custodial services. Herein, three in-situ techniques, GC-MS, 1H NMR and FT-IR spectroscopy, with searchable librar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc041d79a49b8a1305fec75032110c5
https://ueaeprints.uea.ac.uk/id/eprint/91042/

Comparative study of the analysis of seized samples by GC-MS

Autor: David I, Dixon, Lysbeth H, Antonides, Andrew, Costello, Benjamin, Crane, Arran, Embleton, Mark L, Fletcher, Nicolas, Gilbert, Matthew C, Hulme, Molly J, James, Michael A, Lever, Conner J, Maccallum, Molly F, Millea, Jessica L, Pimlott, Thomas B R, Robertson, Nathan E, Rudge, Christopher J, Schofield, Filip, Zukowicz, E Kate, Kemsley, Oliver B, Sutcliffe, Ryan E, Mewis

Publikováno v: Journal of pharmaceutical and biomedical analysis. 219

Rapid analysis of surrendered or seized drug samples provides important intelligence for health (e.g. treatment or harm reduction), and custodial services. Herein, three in-situ techniques, GC-MS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0941eee0e18912cfb4e62162918c9dc6
https://pubmed.ncbi.nlm.nih.gov/35914505

A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain

Autor: Simon Erlendsson, Gith Noes-Holt, Kathrine L. Jensen, Sofie E Pedersen, Ulrik Gether, Lise Arleth, Søren Roi Midtgaard, Klaus B. Nissen, Kenneth L. Madsen, Mette Rathje, Nikolaj R. Christensen, Kristian Strømgaard, Christian Bjerggaard Vaegter, Marta De Luca, Mette Richner, Anders Bach, Dennis Bo Jensen, Andreas T. Sørensen, Michèle Schönauer, Ina Ammendrup-Johnsen, C. F. Meehan, Michael Brett Lever, Astrid B Hansen, Kaare Teilum, Christian R. O. Bartling

Publikováno v: Christensen, N R, De Luca, M, Lever, M B, Richner, M, Hansen, A B, Noes-Holt, G, Jensen, K L, Rathje, M, Jensen, D B, Erlendsson, S, Bartling, C R, Ammendrup-Johnsen, I, Pedersen, S E, Schönauer, M, Nissen, K B, Midtgaard, S R, Teilum, K, Arleth, L, Sørensen, A T, Bach, A, Strømgaard, K, Meehan, C F, Vaegter, C B, Gether, U & Madsen, K L 2020, ' A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain ', EMBO Molecular Medicine, vol. 12, 11248 . https://doi.org/10.15252/emmm.201911248
Christensen, N R, De Luca, M, Lever, M B, Richner, M, Hansen, A B, Noes-Holt, G, Jensen, K L, Rathje, M, Jensen, D B, Erlendsson, S, Bartling, C R O, Ammendrup-Johnsen, I, Pedersen, S E, Schönauer, M, Nissen, K B, Midtgaard, S R, Teilum, K, Arleth, L, Sørensen, A T, Bach, A, Strømgaard, K, Meehan, C F, Vægter, C B, Gether, U & Madsen, K L 2020, ' A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain ', EMBO Molecular Medicine, vol. 12, no. 6, e11248 . https://doi.org/10.15252/emmm.201911248
EMBO molecular medicine 12(6), e11248 (2020). doi:10.15252/emmm.201911248
EMBO Molecular Medicine, Vol 12, Iss 6, Pp n/a-n/a (2020)
EMBO Molecular Medicine

EMBO molecular medicine 12(6), e11248 (2020). doi:10.15252/emmm.201911248
Maladaptive plasticity involving increased expression of AMPA‐type glutamate receptors is involved in several pathologies, including neuropathic pain, but direct inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f2a79c35640aba4c47c10fe446bf83
https://pure.au.dk/portal/da/publications/a-highaffinity-bivalent-pdz-domain-inhibitor-complexes-pick1-to-alleviate-neuropathic-pain(1f97eff6-28ca-4b06-a6fe-7e8ac62e3100).html