Zobrazeno 1 - 10
of 180
pro vyhledávání: '"Michael A, Joyce"'
Autor:
Joseph K. Sampson Duncan, Danyang Xu, Maria Licursi, Michael A. Joyce, Holly A. Saffran, Kaiwen Liu, Jin Gohda, D. Lorne Tyrrell, Yasushi Kawaguchi, Kensuke Hirasawa
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Interferon regulatory factors (IRFs) are key elements of antiviral innate responses that regulate the transcription of interferons (IFNs) and IFN-stimulated genes (ISGs). While the sensitivity of human coronaviruses to IFNs has been characterized, an
Externí odkaz:
https://doaj.org/article/85bc25bd97804d21b8ce1febd62737a6
Autor:
George Giorgi Babuadze, Hugues Fausther-Bovendo, Marc-Antoine deLaVega, Brandon Lillie, Maedeh Naghibosadat, Nariman Shahhosseini, Michael A. Joyce, Holly A. Saffran, D. Lorne Tyrrell, Darryl Falzarano, Chandrika Senthilkumaran, Natasha Christie-Holmes, Steven Ahn, Scott D. Gray-Owen, Arinjay Banerjee, Samira Mubareka, Karen Mossman, Chanel Dupont, Jannie Pedersen, Mark-Alexandre Lafrance, Gary P. Kobinger, Robert Kozak
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-11 (2022)
Abstract The SARS-CoV-2 pandemic is an ongoing threat to global health, and wide-scale vaccination is an efficient method to reduce morbidity and mortality. We designed and evaluated two DNA plasmid vaccines, based on the pIDV-II system, expressing t
Externí odkaz:
https://doaj.org/article/82794801787e446aa4f47a9d3ccbe1b5
Autor:
Wayne Vuong, Muhammad Bashir Khan, Conrad Fischer, Elena Arutyunova, Tess Lamer, Justin Shields, Holly A. Saffran, Ryan T. McKay, Marco J. van Belkum, Michael A. Joyce, Howard S. Young, D. Lorne Tyrrell, John C. Vederas, M. Joanne Lemieux
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Coronavirus main protease is essential for viral polyprotein processing and replication. Here Vuong et al. report efficient inhibition of SARS-CoV-2 replication by the dipeptide-based protease inhibitor GC376 and its parent GC373, which were original
Externí odkaz:
https://doaj.org/article/3c902c5ef40f40398c856f91dffa7d74
Autor:
Bradford S. Hoppe, Raymond B. Mailhot Vega, Nancy P. Mendenhall, Eric S. Sandler, William B. Slayton, Howard Katzenstein, Michael J. Joyce, Zuofeng Li, Stella Flampouri
Publikováno v:
International Journal of Particle Therapy, Vol 6, Iss 4, Pp 1-6 (2020)
Background: Local relapse is a predominant form of recurrence among pediatric patients with Hodgkin lymphoma (PHL). Although PHL radiotherapy doses have been approximately 20 Gy, adults with Hodgkin lymphoma receiving 30 to 36 Gy experience fewer in-
Externí odkaz:
https://doaj.org/article/e8df6e5ee94843579f76659bc71100d5
Autor:
Faisal Hossain, Qiming Shen, Nicholas Balasuriya, John Lok Man Law, Michael Logan, Michael Houghton, D. Lorne Tyrrell, Michael A. Joyce, Michael J. Serpe
Publikováno v:
Analytical Chemistry. 95:7620-7629
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::212d44019ac48bf289b59983b74ba579
https://doi.org/10.1021/acs.analchem.3c00481
https://doi.org/10.1021/acs.analchem.3c00481
Autor:
Manisha Pandey, Victoria Ozberk, Sharareh Eskandari, Ahmed O Shalash, Michael A Joyce, Holly A Saffran, Christopher J Day, Ailin Lepletier, Belinda L Spillings, Jamie‐Lee Mills, Ainslie Calcutt, Fan Fan, James T Williams, Danielle I Stanisic, Laetitia Hattingh, John Gerrard, Mariusz Skwarczynski, Johnson Mak, Michael P Jennings, Istvan Toth, D Lorne Tyrrell, Michael F Good
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 3, Pp n/a-n/a (2021)
Abstract Objectives A major COVID‐19 vaccine strategy is to induce antibodies that prevent interaction between the Spike protein's receptor‐binding domain (RBD) and angiotensin‐converting enzyme 2 (ACE2). These vaccines will also induce T‐cel
Externí odkaz:
https://doaj.org/article/e84bde1bc9874220bdf3a2aceb319bda
Autor:
Michael A Joyce, Karyn M Berry-Wynne, Theodore Dos Santos, William R Addison, Nicola McFarlane, Tom Hobman, D Lorne Tyrrell
Publikováno v:
PLoS Pathogens, Vol 15, Iss 8, p e1007949 (2019)
Host encounters with viruses lead to an innate immune response that must be rapid and broadly targeted but also tightly regulated to avoid the detrimental effects of unregulated interferon expression. Viral stimulation of host negative regulatory mec
Externí odkaz:
https://doaj.org/article/dda2e641c2df4f408e4d04ca7ddf8b35
Autor:
Yanming Liu, Teresa Kumblathan, Michael A. Joyce, D. Lorne Tyrrell, Graham Tipples, Xiaoli Pang, Xing-Fang Li, X. Chris Le
Publikováno v:
ACS Measurement Science Au.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb020e2379610934ec39842ae0ccc93b
https://doi.org/10.1021/acsmeasuresciau.3c00005
https://doi.org/10.1021/acsmeasuresciau.3c00005
Publikováno v:
J Pediatr Pharmacol Ther
OBJECTIVE The purpose of this study was to evaluate the efficacy of a standardized premedication and therapeutic drug monitoring (TDM) protocol to prevent hypersensitivity reactions from pegaspargase infusions. Pegaspargase is an essential therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8185d7026d765bb080b67ef9aa262d1b
https://doi.org/10.5863/1551-6776-27.3.232
https://doi.org/10.5863/1551-6776-27.3.232
Autor:
Connie Le, Reshma Sirajee, Rineke Steenbergen, Michael A. Joyce, William R. Addison, D. Lorne Tyrrell
Publikováno v:
Viruses, Vol 13, Iss 1, p 97 (2021)
An estimated two billion people worldwide have been infected with hepatitis B virus (HBV). Despite the high infectivity of HBV in vivo, a lack of easily infectable in vitro culture systems hinders studies of HBV. Overexpression of the sodium taurocho
Externí odkaz:
https://doaj.org/article/ee23d1679ae14d3aab1ccd8deb04421b