Zobrazeno 1 - 10
of 467
pro vyhledávání: '"Michael A, Hollingsworth"'
Autor:
Dandan Zheng, Paul M. Grandgenett, Qi Zhang, Michael Baine, Yu Shi, Qian Du, Xiaoying Liang, Jeffrey Wong, Subhan Iqbal, Kiersten Preuss, Ahsan Kamal, Hongfeng Yu, Huijing Du, Michael A. Hollingsworth, Chi Zhang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Addressing the significant level of variability exhibited by pancreatic cancer necessitates the adoption of a systems biology approach that integrates molecular data, biological properties of the tumors, medical images, and clinical features
Externí odkaz:
https://doaj.org/article/f97d27aec9334a00bd1de8057b0e2eed
Autor:
Nicholas J Mullen, Surendra K Shukla, Ravi Thakur, Sai Sundeep Kollala, Dezhen Wang, Nina Chaika, Juan F Santana, William R Miklavcic, Drew A LaBreck, Jayapal Reddy Mallareddy, David H Price, Amarnath Natarajan, Kamiya Mehla, David B Sykes, Michael A Hollingsworth, Pankaj K Singh
Publikováno v:
eLife, Vol 12 (2024)
Pyrimidine nucleotide biosynthesis is a druggable metabolic dependency of cancer cells, and chemotherapy agents targeting pyrimidine metabolism are the backbone of treatment for many cancers. Dihydroorotate dehydrogenase (DHODH) is an essential enzym
Externí odkaz:
https://doaj.org/article/3d1d4ecaa2d9414c902c7249254c6fee
Autor:
Jihao Xu, Jae‐Seok Roe, EunJung Lee, Claudia Tonelli, Keely Y. Ji, Omar W. Younis, Tim D.D. Somervile, Melissa Yao, Joseph P. Milazzo, Herve Tiriac, Anna M. Kolarzyk, Esak Lee, Jean L. Grem, Audrey J. Lazenby, James A. Grunkemeyer, Michael A. Hollingsworth, Paul M. Grandgenett, Alexander D. Borowsky, Youngkyu Park, Christopher R. Vakoc, David A. Tuveson, Chang‐Il Hwang
Publikováno v:
Advanced Science, Vol 11, Iss 6, Pp n/a-n/a (2024)
Abstract Engrailed‐1 (EN1) is a critical homeodomain transcription factor (TF) required for neuronal survival, and EN1 expression has been shown to promote aggressive forms of triple negative breast cancer. Here, it is reported that EN1 is aberrant
Externí odkaz:
https://doaj.org/article/fa247bd53d254f95b68bf57810402255
Autor:
Seok‐Yeong Yu, Yi Luan, Siyuan Tang, Amirhossein Abazarikia, Rosemary Dong, Thomas C. Caffrey, Michael A. Hollingsworth, David Oupicky, So‐Youn Kim
Publikováno v:
Advanced Science, Vol 10, Iss 16, Pp n/a-n/a (2023)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with high incidence rates of metastasis and cachexia. High circulating activin A, a homodimer of inhibin βA subunits that are encoded by INHBA gene, predicts poor sur
Externí odkaz:
https://doaj.org/article/93585807fc00477cb1617396a81a9138
Autor:
Pauline C. Xu, Mikyoung You, Seok-Yeong Yu, Yi Luan, Maya Eldani, Thomas C. Caffrey, Paul M. Grandgenett, Kelly A. O’Connell, Surendra K. Shukla, Chandramohan Kattamuri, Michael A. Hollingsworth, Pankaj K. Singh, Thomas B. Thompson, Soonkyu Chung, So-Youn Kim
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Pancreatic ductal adenocarcinoma (PDAC) patients display distinct phenotypes of cachexia development, with either adipose tissue loss preceding skeletal muscle wasting or loss of only adipose tissue. Activin A levels were measured in serum a
Externí odkaz:
https://doaj.org/article/874a42a53e0841f5abfc8817968cf7a6
Autor:
Kaitlin M Dailey, James M Small, Jessica E Pullan, Seth Winfree, Krysten E Vance, Megan Orr, Sanku Mallik, Kenneth W Bayles, Michael A Hollingsworth, Amanda E Brooks
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0289183 (2023)
Clostridium novyi has demonstrated selective efficacy against solid tumors largely due to the microenvironment contained within dense tumor cores. The core of a solid tumor is typically hypoxic, acidic, and necrotic-impeding the penetration of curren
Externí odkaz:
https://doaj.org/article/b537482f21ef4474b5d908f2d67ccbb3
Autor:
Pinaki Mondal, Neesha S. Patel, Katie Bailey, Shruthishree Aravind, Sara B. Cartwright, Michael A. Hollingsworth, Audrey J. Lazenby, Mark A. Carlson
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 1 (2023)
Externí odkaz:
https://doaj.org/article/481684fb18ae4673b2205b6a20c578a1
Autor:
Jason M. Roe, Kevin Seely, Caleb J. Bussard, Emily Eischen Martin, Elizabeth G. Mouw, Kenneth W. Bayles, Michael A. Hollingsworth, Amanda E. Brooks, Kaitlin M. Dailey
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 2004 (2023)
Oncolytic bacteria are a classification of bacteria with a natural ability to specifically target solid tumors and, in the process, stimulate a potent immune response. Currently, these include species of Klebsiella, Listeria, Mycobacteria, Streptococ
Externí odkaz:
https://doaj.org/article/cbabaab1fee549e4bb6e1a4925d48eec
Autor:
Jeffrey Wong, Michael Baine, Sarah Wisnoskie, Nathan Bennion, Dechun Zheng, Lei Yu, Vipin Dalal, Michael A. Hollingsworth, Chi Lin, Dandan Zheng
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Radiomics is a method to mine large numbers of quantitative imaging features and develop predictive models. It has shown exciting promise for improved cancer decision support from early detection to personalized precision treatment, and ther
Externí odkaz:
https://doaj.org/article/bcdb7caa7f194e2184b552cfd4028e59
Autor:
Katie L. Bailey, Sara B. Cartwright, Neesha S. Patel, Neeley Remmers, Audrey J. Lazenby, Michael A. Hollingsworth, Mark A. Carlson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract We describe our initial studies in the development of an orthotopic, genetically defined, large animal model of pancreatic cancer. Primary pancreatic epithelial cells were isolated from pancreatic duct of domestic pigs. A transformed cell li
Externí odkaz:
https://doaj.org/article/7af2948a4821425da7bdc200f1faf33e