Zobrazeno 1 - 10
of 946
pro vyhledávání: '"Michael A, Gray"'
Autor:
Stephen T. Vernon, Stuart Brentnall, Danielle J Currie, Cindy Peng, Michael P. Gray, Giordano Botta, Deo Mujwara, Stephen J. Nicholls, Stuart M. Grieve, Julie Redfern, Clara Chow, Jean-Frederic Levesque, Peter J. Meikle, Garry Jennings, Zanfina Ademi, Andrew Wilson, Gemma A. Figtree
Publikováno v:
American Journal of Preventive Cardiology, Vol 18, Iss , Pp 100672- (2024)
Background: Primary prevention programs utilising traditional risk scores fail to identify all individuals who suffer acute cardiovascular events. We aimed to model the impact and cost effectiveness of incorporating a Polygenic risk scores (PRS) into
Externí odkaz:
https://doaj.org/article/b786deb82829480a8118d138be0a781e
Autor:
Matus Valach, Sandrine Moreira, Celine Petitjean, Corinna Benz, Anzhelika Butenko, Olga Flegontova, Anna Nenarokova, Galina Prokopchuk, Tom Batstone, Pascal Lapébie, Lionnel Lemogo, Matt Sarrasin, Paul Stretenowich, Pragya Tripathi, Euki Yazaki, Takeshi Nara, Bernard Henrissat, B. Franz Lang, Michael W. Gray, Tom A. Williams, Julius Lukeš, Gertraud Burger
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background Diplonemid flagellates are among the most abundant and species-rich of known marine microeukaryotes, colonizing all habitats, depths, and geographic regions of the world ocean. However, little is known about their genomes, biology
Externí odkaz:
https://doaj.org/article/d52b66df69fd49b39786a1f81803704a
Autor:
Michael Lauria, Bradley Stiehl, Anand Santhanam, Dylan O’Connell, Louise Naumann, Michael McNitt-Gray, Ann Raldow, Jonathan Goldin, Igor Barjaktarevic, Daniel A. Low
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
PurposeRecent advancements in obtaining image-based biomarkers from CT images have enabled lung function characterization, which could aid in lung interventional planning. However, the regional heterogeneity in these biomarkers has not been well docu
Externí odkaz:
https://doaj.org/article/36db664168264d59a631ea8cd4031bf9
Autor:
Weiqian E. Lee, Marie Besnier, Elijah Genetzakis, Owen Tang, Katharine A. Kott, Stephen T. Vernon, Michael P. Gray, Stuart M. Grieve, Michael Kassiou, Gemma A. Figtree
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 22 (2023)
Improved human-relevant preclinical models of coronary artery disease (CAD) are needed to improve translational research and drug discovery. Mitochondrial dysfunction and associated oxidative stress contribute to endothelial dysfunction and are a sig
Externí odkaz:
https://doaj.org/article/6c38c99fec4345bbb0d31db51d4056fb
Autor:
Katharine A. Kott, Elijah Genetzakis, Michael P. Gray, Peter Hansen, Helen M. McGuire, Jean Y. Yang, Stuart M. Grieve, Stephen T. Vernon, Gemma A. Figtree
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1187 (2023)
Risk-factor-based scoring systems for atherosclerotic coronary artery disease (CAD) remain concerningly inaccurate at the level of the individual and would benefit from the addition of biomarkers that correlate with atherosclerosis burden directly. W
Externí odkaz:
https://doaj.org/article/e41e7fd4fd31493d8967924070904f7f
Autor:
Catarina Pereira, Alexander Mazein, Carlos M. Farinha, Michael A. Gray, Karl Kunzelmann, Marek Ostaszewski, Irina Balaur, Margarida D. Amaral, Andre O. Falcao
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Cystic fibrosis (CF) is a life-threatening autosomal recessive disease caused by more than 2100 mutations in the CF transmembrane conductance regulator (CFTR) gene, generating variability in disease severity among individuals with CF sharing
Externí odkaz:
https://doaj.org/article/61bb59c2153246c1a0ae7d255451f7f9
A Cell-Based Optimised Approach for Rapid and Efficient Gene Editing of Human Pluripotent Stem Cells
Autor:
Sara Cuevas-Ocaña, Jin Ye Yang, Magomet Aushev, George Schlossmacher, Christine E. Bear, Nicholas R. F. Hannan, Neil D. Perkins, Janet Rossant, Amy P. Wong, Michael A. Gray
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 10266 (2023)
Introducing or correcting disease-causing mutations through genome editing in human pluripotent stem cells (hPSCs) followed by tissue-specific differentiation provide sustainable models of multiorgan diseases, such as cystic fibrosis (CF). However, l
Externí odkaz:
https://doaj.org/article/531cdd449add4766881e623a2c423d1d
Autor:
Dantong Zhu, Stephen T. Vernon, Zac D’Agostino, Jingqin Wu, Corey Giles, Adam S. Chan, Katharine A. Kott, Michael P. Gray, Alireza Gholipour, Owen Tang, Habtamu B. Beyene, Ellis Patrick, Stuart M. Grieve, Peter J. Meikle, Gemma A. Figtree, Jean Y. H. Yang
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 917 (2023)
The current coronary artery disease (CAD) risk scores for predicting future cardiovascular events rely on well-recognized traditional cardiovascular risk factors derived from a population level but often fail individuals, with up to 25% of first-time
Externí odkaz:
https://doaj.org/article/a7a6a642531446639ca8d3b14940fa40
Autor:
Lenka Horváthová, Vojtěch Žárský, Tomáš Pánek, Romain Derelle, Jan Pyrih, Alžběta Motyčková, Veronika Klápšťová, Martina Vinopalová, Lenka Marková, Luboš Voleman, Vladimír Klimeš, Markéta Petrů, Zuzana Vaitová, Ivan Čepička, Klára Hryzáková, Karel Harant, Michael W. Gray, Mohamed Chami, Ingrid Guilvout, Olivera Francetic, B. Franz Lang, Čestmír Vlček, Anastasios D. Tsaousis, Marek Eliáš, Pavel Doležal
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Bacteria use the type 2 secretion system to secrete enzymes and toxins across the outer membrane to the environment. Here the authors analyse the T2SS pathway in three protist lineages and suggest that the early mitochondrion may have been capable of
Externí odkaz:
https://doaj.org/article/994e70e482df4d9db87d65239e08f13f
Autor:
JinHeng Lin, Michael Taggart, Lee Borthwick, Andrew Fisher, Malcolm Brodlie, M. Flori Sassano, Robert Tarran, Michael A. Gray
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Tobacco smoking is the largest risk factor for developing chronic obstructive pulmonary disease (COPD), and is associated with hyperresponsiveness of airway smooth muscle (ASM). Chronic exposure to cigarette smoke (CS) leads to airway inflam
Externí odkaz:
https://doaj.org/article/72b7419af6304da68bba73654931260e