Zobrazeno 1 - 10
of 274
pro vyhledávání: '"Michael A, Geeves"'
Autor:
Janeska J. de Jonge, Andreas Graw, Vasileios Kargas, Christopher Batters, Antonino F. Montanarella, Tom O’Loughlin, Chloe Johnson, Susan D. Arden, Alan J. Warren, Michael A. Geeves, John Kendrick-Jones, Nathan R. Zaccai, Markus Kröss, Claudia Veigel, Folma Buss
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Myosin motors perform many fundamental functions in eukaryotic cells by providing force generation, transport or tethering capacity. Motor activity control within the cell involves on/off switches, however, few examples are known of how myos
Externí odkaz:
https://doaj.org/article/7154c67ddb744e59a37c38b04052c87d
Autor:
Chloe A. Johnson, Jake E. McGreig, Sarah T. Jeanfavre, Jonathan Walklate, Carlos D. Vera, Marta Farré, Daniel P. Mulvihill, Anthony J. Baines, Martin Ridout, Leslie A. Leinwand, Mark N. Wass, Michael A. Geeves
Publikováno v:
PLoS Biology, Vol 19, Iss 6 (2021)
The speed of muscle contraction is related to body size; muscles in larger species contract at slower rates. Since contraction speed is a property of the myosin isoform expressed in a muscle, we investigated how sequence changes in a range of muscle
Externí odkaz:
https://doaj.org/article/434b42c89d844110850ecb649b239327
Autor:
David R. Trentham, Michael A. Geeves
Publikováno v:
Biographical Memoirs of Fellows of the Royal Society. 74:211-235
Herbert (Freddie) Gutfreund (hereafter called Freddie) made fundamental contributions to molecular enzymology—a name he introduced into the UK Biochemical Society as its first subgroup and as a discipline within the field of biochemistry. Freddie w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31542de18d22ee5fd88f44891a467536
https://doi.org/10.1098/rsbm.2022.0024
https://doi.org/10.1098/rsbm.2022.0024
Autor:
Karen Baker, Irene A Gyamfi, Gregory I Mashanov, Justin E Molloy, Michael A Geeves, Daniel P Mulvihill
Publikováno v:
eLife, Vol 8 (2019)
Cells respond to changes in their environment through signaling networks that modulate cytoskeleton and membrane organization to coordinate cell-cycle progression, polarized cell growth and multicellular development. Here, we define a novel regulator
Externí odkaz:
https://doaj.org/article/bbfa004fdeba404386462db57bec03b4
Autor:
Kristina B. Kooiker, Saffie Mohran, Kyrah L. Turner, Weikang Ma, Galina Flint, Lin Qi, Chengqian Gao, Yahan Zheng, Timothy S McMillen, Christian Mandrycky, Amy Martinson, Max Mahoney-Schaefer, Jeremy C. Freeman, Elijah Gabriela Costales Arenas, An-Yu Tu, Thomas C. Irving, Michael A. Geeves, Bertrand C.W. Tanner, Michael Regnier, Jennifer Davis, Farid Moussavi-Harami
Publikováno v:
bioRxiv
Modulating myosin function is a novel therapeutic approach in patients with cardiomyopathy. Detailed mechanism of action of these agents can help predict potential unwanted affects and identify patient populations that can benefit most from them. Dan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f481be9f2ba5b7761fa7775d80b74f8c
https://doi.org/10.1101/2023.01.31.526380
https://doi.org/10.1101/2023.01.31.526380
Autor:
Corrado Poggesi, Michael Regnier, Jennifer Davis, Momcilo Prodanovic, Michael A. Geeves, Joseph D. Powers, Srboljub M. Mijailovich
Publikováno v:
Journal of Molecular and Cellular Cardiology
J Mol Cell Cardiol
J Mol Cell Cardiol
One of the complexities of understanding the pathology of familial forms of cardiac diseases is the level of mutation incorporation in sarcomeres. Computational models of the sarcomere that are spatially explicit offer an approach to study aspects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5022f221e11372ffcd25a4ecd12d98e0
https://doi.org/10.1016/j.yjmcc.2021.02.009
https://doi.org/10.1016/j.yjmcc.2021.02.009
Publikováno v:
Journal of Biological Chemistry. 295:14522-14535
We investigated the biochemical and biophysical properties of one of the four alternative exon-encoded regions within the Drosophila myosin catalytic domain. This region is encoded by alternative exons 3a and 3b and includes part of the N-terminal β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ed13609103219aa2fbbe41f76d8d59
https://doi.org/10.1074/jbc.ra120.014684
https://doi.org/10.1074/jbc.ra120.014684
Publikováno v:
Biophysical Journal. 122:402a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a94a8c618d0ef411ebb636a8bf512359
https://doi.org/10.1016/j.bpj.2022.11.2191
https://doi.org/10.1016/j.bpj.2022.11.2191
Autor:
Kristina B. Kooiker, Saffie Mohran, Weikang Ma, Galina V. Flint, Kerry Y. Kao, Lin Qi, Timothy McMillen, Stephanie Neys, Christian Mandrycky, Thomas C. Irving, Michael A. Geeves, Michael Regnier, Farid Moussavi-Harami
Publikováno v:
Biophysical Journal. 122:453a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb64d520c9df40b3573d39d63b251aff
https://doi.org/10.1016/j.bpj.2022.11.2439
https://doi.org/10.1016/j.bpj.2022.11.2439
Autor:
Lindsey A. Lee, Samantha K. Barrick, Artur Meller, Jonathan Walklate, Jeffrey M. Lotthammer, Jian Wei Tay, W. Tom Stump, Gregory Bowman, Michael A. Geeves, Michael J. Greenberg, Leslie A. Leinwand
Publikováno v:
Journal of Biological Chemistry. 299:102657
Myosin heavy chain 7b (MYH7b) is an evolutionarily ancient member of the sarcomeric myosin family, which typically supports striated muscle function. However, in mammals, alternative splicing prevents MYH7b protein production in cardiac and most skel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d0d23cd763d9ce76cb4a05b530c7f7
https://doi.org/10.1016/j.jbc.2022.102657
https://doi.org/10.1016/j.jbc.2022.102657