Zobrazeno 1 - 10
of 263
pro vyhledávání: '"Michael A, Fischbach"'
Autor:
Prasenjit Prasad Saha, Valentin Gogonea, Wendy Sweet, Maradumane L. Mohan, Khuraijam Dhanachandra Singh, James T. Anderson, Deepthi Mallela, Conner Witherow, Niladri Kar, Kate Stenson, Terri Harford, Michael A. Fischbach, J. Mark Brown, Sadashiva S. Karnik, Christine S. Moravec, Joseph A. DiDonato, Sathyamangla Venkata Naga Prasad, Stanley L. Hazen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Allosteric modulation is a central mechanism for metabolic regulation but has yet to be described for a gut microbiota-host interaction. Phenylacetylglutamine (PAGln), a gut microbiota-derived metabolite, has previously been clinically assoc
Externí odkaz:
https://doaj.org/article/135a6fb0bc4149b78a90558a91ecc051
Autor:
Annika Wahlström, Ariel Brumbaugh, Wilhelm Sjöland, Lisa Olsson, Hao Wu, Marcus Henricsson, Annika Lundqvist, Kassem Makki, Stanley L. Hazen, Göran Bergström, Hanns-Ulrich Marschall, Michael A. Fischbach, Fredrik Bäckhed
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Alterations in gut microbiota composition are suggested to contribute to cardiometabolic diseases, in part by producing bioactive molecules. Some of the metabolites are produced by very low abundant bacterial taxa, which largely have been ne
Externí odkaz:
https://doaj.org/article/7c3061f41e2741e1be79161e6894712b
Autor:
Ina Nemet, Masanori Funabashi, Xinmin S. Li, Mohammed Dwidar, Naseer Sangwan, Sarah M. Skye, Kymberleigh A. Romano, Tomas Cajka, Brittany D. Needham, Sarkis K. Mazmanian, Adeline M. Hajjar, Federico E. Rey, Oliver Fiehn, W. H. Wilson Tang, Michael A. Fischbach, Stanley L. Hazen
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTp-Cresol sulfate (pCS) and indoxyl sulfate (IS), gut microbiome-derived metabolites, are traditionally associated with cardiovascular disease (CVD) risks in the setting of impaired kidney function. While pharmacologic provision of pCS or IS c
Externí odkaz:
https://doaj.org/article/b42c9dbc2abc4d00ac418c59c42a7a26
Autor:
Kali M. Pruss, Haoqing Chen, Yuanyuan Liu, William Van Treuren, Steven K. Higginbottom, John B. Jarman, Curt R. Fischer, Justin Mak, Beverly Wong, Tina M. Cowan, Michael A. Fischbach, Justin L. Sonnenburg, Dylan Dodd
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Here, using a mouse model, the authors report a previously undescribed role for medium-chain acyl-CoA dehydrogenase in host metabolism of gut microbiota metabolites, and show that circulating compounds, including the abundant organic acid hippurate,
Externí odkaz:
https://doaj.org/article/14334ccffc5848da904c149209a88138
Autor:
Ibrahim Choucair, Ina Nemet, Lin Li, Margaret A. Cole, Sarah M. Skye, Jennifer D. Kirsop, Michael A. Fischbach, Valentin Gogonea, J. Mark Brown, W. H. Wilson Tang, Stanley L. Hazen
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 2, Pp 159-177 (2020)
Bile acids (BAs) serve multiple biological functions, ranging from the absorption of lipids and fat-soluble vitamins to serving as signaling molecules through the direct activation of dedicated cellular receptors. Synthesized by both host and microbi
Externí odkaz:
https://doaj.org/article/0593eecf7402432a8e1d8b74a411d717
Autor:
Victória Pascal Andreu, Hannah E. Augustijn, Koen van den Berg, Justin J. J. van der Hooft, Michael A. Fischbach, Marnix H. Medema
Publikováno v:
mSystems, Vol 6, Iss 5 (2021)
ABSTRACT Microbial gene clusters encoding the biosynthesis of primary and secondary metabolites play key roles in shaping microbial ecosystems and driving microbiome-associated phenotypes. Although effective approaches exist to evaluate the metabolic
Externí odkaz:
https://doaj.org/article/36246458631c463292a7bd6febbb49f1
Autor:
Y. Erin Chen, Djenet Bousbaine, Alessandra Veinbachs, Katayoon Atabakhsh, Alex Dimas, Victor K. Yu, Aishan Zhao, Nora J. Enright, Kazuki Nagashima, Yasmine Belkaid, Michael A. Fischbach
Publikováno v:
Science. 380:203-210
Certain bacterial colonists induce a highly specific T cell response. A hallmark of this encounter is that adaptive immunity develops preemptively, in the absence of an infection. However, the functional properties of colonist-induced T cells are not
Autor:
Marco Jost, Amy N Jacobson, Jeffrey A Hussmann, Giana Cirolia, Michael A Fischbach, Jonathan S Weissman
Publikováno v:
eLife, Vol 10 (2021)
Dendritic cells (DCs) regulate processes ranging from antitumor and antiviral immunity to host-microbe communication at mucosal surfaces. It remains difficult, however, to genetically manipulate human DCs, limiting our ability to probe how DCs elicit
Externí odkaz:
https://doaj.org/article/af2eea39e034442491abb1656b561b49
Autor:
Yogesh Bhattarai, Si Jie, David R. Linden, Sayak Ghatak, Ruben A.T. Mars, Brianna B. Williams, Meng Pu, Justin L. Sonnenburg, Michael A. Fischbach, Gianrico Farrugia, Lei Sha, Purna C. Kashyap
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101798- (2020)
Summary: Recent studies emphasize the role of microbial metabolites in regulating gastrointestinal (GI) physiology through activation of host receptors, highlighting the potential for inter-kingdom signaling in treating GI disorders. In this study, w
Externí odkaz:
https://doaj.org/article/b5bee85c22b34b76b33cddfd843fc131
Autor:
Alexander M Kloosterman, Peter Cimermancic, Somayah S Elsayed, Chao Du, Michalis Hadjithomas, Mohamed S Donia, Michael A Fischbach, Gilles P van Wezel, Marnix H Medema
Publikováno v:
PLoS Biology, Vol 18, Iss 12, p e3001026 (2020)
Microbial natural products constitute a wide variety of chemical compounds, many which can have antibiotic, antiviral, or anticancer properties that make them interesting for clinical purposes. Natural product classes include polyketides (PKs), nonri
Externí odkaz:
https://doaj.org/article/37a2f5ceef8e46f8a72e0714fee61104