Zobrazeno 1 - 10
of 329
pro vyhledávání: '"Michael Springer"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Researchers and policymakers have proposed systems to detect novel pathogens earlier than existing surveillance systems by monitoring samples from hospital patients, wastewater, and air travel, in order to mitigate future pandemics. How much
Externí odkaz:
https://doaj.org/article/460a3e7aa44c43a98882186b110252b9
Autor:
Maria Laggner, Alfred Gugerell, Dragan Copic, Markus Jeitler, Michael Springer, Anja Peterbauer, Christopher Kremslehner, Manuel Filzwieser-Narzt, Florian Gruber, Sibylle Madlener, Michael Erb, Joachim Widder, Wolfgang Lechner, Dietmar Georg, Michael Mildner, Hendrik Jan Ankersmit
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 14-27 (2021)
Cell-free secretomes represent a promising new therapeutic avenue in regenerative medicine, and γ-irradiation of human peripheral blood mononuclear cells (PBMCs) has been shown to promote the release of paracrine factors with high regenerative poten
Externí odkaz:
https://doaj.org/article/76252835b5b848bfa2306b9f00468b98
Autor:
Jason Qian, Sarah A. Boswell, Christopher Chidley, Zhi-xiang Lu, Mary E. Pettit, Benjamin L. Gaudio, Jesse M. Fajnzylber, Ryan T. Ingram, Rebecca H. Ward, Jonathan Z. Li, Michael Springer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Current state-of-the-art diagnostics for infectious diseases are sensitive but require extensive equipment. Here the authors develop an enhanced recombinase polymerase amplification reaction for SARS-CoV-2 that allows for inexpensive and rapid testin
Externí odkaz:
https://doaj.org/article/1fea287ae7e64a1da7dfd8eee7f11721
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 9, p e1008691 (2021)
Quantitative traits are measurable phenotypes that show continuous variation over a wide phenotypic range. Enormous effort has recently been put into determining the genetic influences on a variety of quantitative traits with mixed success. We identi
Externí odkaz:
https://doaj.org/article/81dbae594fb9461f972688af74a73a57
Publikováno v:
eLife, Vol 10 (2021)
Bimodal gene expression by genetically identical cells is a pervasive feature of signaling networks and has been suggested to allow organisms to hedge their ‘bets’ in uncertain conditions. In the galactose-utilization (GAL) pathway of Saccharomyc
Externí odkaz:
https://doaj.org/article/fe2b50e6e9d047fdb85c9dd1e0bbd5cd
Autor:
Dan Davidi, Susan Fitzgerald, Hannah L. Glaspell, Samantha Jalbert, Catherine M. Klapperich, Lena Landaverde, Stylianos Maheras, Stephanie E. Mattoon, Vanessa M. Britto, Giang T. Nguyen, Judy T. Platt, Kayla Kuhfeldt, Hannah Landsberg, Cecilia W. Stuopis, Joshua E. Turse, Davidson H. Hamer, Michael Springer
Publikováno v:
Cell Reports: Methods, Vol 1, Iss 1, Pp 100005- (2021)
Asymptomatic surveillance testing together with COVID-19-related research can lead to positive SARS-CoV-2 tests resulting not from true infections, but non-infectious, non-hazardous by-products of research (amplicons). Amplicons can be widespread and
Externí odkaz:
https://doaj.org/article/afe5a0b622fe45318d5a84b15450b6bf
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 12, p e1007960 (2020)
Metabolic networks undergo gene expression regulation in response to external nutrient signals. In microbes, the synthesis of enzymes that are used to transport and catabolize less preferred carbon sources is repressed in the presence of a preferred
Externí odkaz:
https://doaj.org/article/dba0ffd7f7554e149017f3ec92610bcf
Autor:
Mathias Mäurer, Klaus Tiel-Wilck, Eckard Oehm, Nils Richter, Michael Springer, Patrick Oschmann, Arndt Manzel, Stefanie Hieke-Schulz, Vera Zingler, Julia A. Kandenwein, Tjalf Ziemssen, Ralf A. Linker
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 12 (2019)
Background: With a large array of disease modifying therapies (DMTs) for relapsing-remitting MS (RRMS), identifying the optimal treatment option for the individual patient is challenging and switching of immunotherapies is often required. The objecti
Externí odkaz:
https://doaj.org/article/0fd09a02da39460790244fd7336013fa
Autor:
Brittany A Petros, Jacquelyn Turcinovic, Nicole L Welch, Laura F White, Eric D Kolaczyk, Matthew R Bauer, Michael Cleary, Sabrina T Dobbins, Lynn Doucette-Stamm, Mitch Gore, Parvathy Nair, Tien G Nguyen, Scott Rose, Bradford P Taylor, Daniel Tsang, Erik Wendlandt, Michele Hope, Judy T Platt, Karen R Jacobson, Tara Bouton, Seyho Yune, Jared R Auclair, Lena Landaverde, Catherine M Klapperich, Davidson H Hamer, William P Hanage, Bronwyn L MacInnis, Pardis C Sabeti, John H Connor, Michael Springer
Publikováno v:
Clinical Infectious Diseases. 76:e400-e408
Background The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly transmissible in vaccinated and unvaccinated populations. The dynamics that govern its establishment and propensity toward fixation (reaching 100
Autor:
Blake W Tye, Nicoletta Commins, Lillia V Ryazanova, Martin Wühr, Michael Springer, David Pincus, L Stirling Churchman
Publikováno v:
eLife, Vol 8 (2019)
To achieve maximal growth, cells must manage a massive economy of ribosomal proteins (r-proteins) and RNAs (rRNAs) to produce thousands of ribosomes every minute. Although ribosomes are essential in all cells, natural disruptions to ribosome biogenes
Externí odkaz:
https://doaj.org/article/b993899821514397b4eeae216b911ee0