Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Michael Platchek"'
Publikováno v:
SLAS Discovery. 25:1197-1213
Cytokines and their receptors play critical roles in biological processes. Dysfunction or dysregulation of cytokines may cause a variety of pathophysiological conditions. Consequently, cytokine profiling and related technologies are essential for bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd2e34ddf0bccd95a2d6c6ce07bb35c
https://doi.org/10.1177/2472555220954389
https://doi.org/10.1177/2472555220954389
Autor:
Deepak K. Rajpal, Pelin Arabacilar, Julius del Rosario, Ganesh M. Sathe, Erding Hu, Yuanjun Guo, Stephen H. Eisennagel, Quinn Lu, Maria Faelth Savitski, Gatto Gregory J, Roberta E. Bernard, Ashley M. Hughes, Mohamad Nayal, Wensheng Xie, Robert N. Willette, Pu Qin, Theresa J. Roethke, George P. Livi, Xiaoyan Qu, Michael P. Quaile, Gerard Joberty, Weike Bao, Robert B. Kirkpatrick, Alan R. Olzinski, Marcus Bantscheff, Christine G. Schnackenberg, Wendy S. Halsey, Thomas Force, Hind Lal, Fe Wright, Michael Platchek, Giovanna Bergamini
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The amino acid response ( AAR ) is an evolutionarily conserved protective mechanism activated by amino acid deficiency through a key kinase, general control nonderepressible 2. In addition to mobilizing amino acids, the AAR broadly affects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c4f7d6e43b4dca4ee10ebc8ec0a651
https://pubmed.ncbi.nlm.nih.gov/28487390
https://pubmed.ncbi.nlm.nih.gov/28487390
Autor:
Zining Wu, Sibongile Mataruse, Alex M. Tamburino, Gang Yao, Jeffrey A. Messer, Yun Ding, Jean Zhang, G Joseph Franklin, Jianghe Deng, Todd L. Graybill, Xin Zeng, David D. Wisnoski, Frank T. Coppo, David I. Israel, Genaro S. Scavello, Jennifer Summerfield, Andrew J. Pope, Michael Platchek, Vera Q. Bodmer, Paolo A. Centrella, Jing Chai, Katie L Sargent Bedard
Publikováno v:
ACS combinatorial science. 17(12)
DNA-encoded small-molecule library technology has recently emerged as a new paradigm for identifying ligands against drug targets. To date, this technology has been used with soluble protein targets that are produced and used in a purified state. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662cc2aa88e33f6c57ffd2c4564e3e69
https://pubmed.ncbi.nlm.nih.gov/26562224
https://pubmed.ncbi.nlm.nih.gov/26562224
Autor:
Zhong Zhong, Michael Platchek, Berta Strulovici, Rebecca Mull, Michael Weber, Mei Cong, Kelli Solly, Priya Kunapuli, Wei Zheng
Publikováno v:
ASSAY and Drug Development Technologies. 3:17-26
Cell-based functional assays are becoming popular in many HTS laboratories because of recent advances in detection and automation technologies. However, the supply of large amounts of live cells with consistent cellular response for day-to-day screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ecfd4c004fa2ea7f20ff374c799f985
https://doi.org/10.1089/adt.2005.3.17
https://doi.org/10.1089/adt.2005.3.17
Autor:
Yan Liu, Michael Platchek, Xin Zeng, Qing Xie, Zining Wu, Dwight M. Morrow, Lorena A. Kallal, Maggie Truong, Pankaj K. Agarwal, Sunny Hung, Andrew J. Pope, Weilin T. Bee, Hong Lin, Burcu Kement
Publikováno v:
Molecular bioSystems. 10(2)
Epigenetic regulation by histone methylation is crucial for proper programming of the genome during development. Homeostasis of histone methylation is balanced by the activities of histone methyltransferases and demethylases. Although these methyltra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903c0b4ce409f6934797df7454a85da7
https://pubmed.ncbi.nlm.nih.gov/24257700
https://pubmed.ncbi.nlm.nih.gov/24257700
Autor:
Peter Haytko, Mei Cong, Thomas Livelli, Zhong Zhong, Mark Federici, Roland Tacke, Natalie Fursov, Michael Platchek
Publikováno v:
Assay and drug development technologies. 3(1)
In this article we describe the use of division-arrested cells for cell-based assays designed for high-throughput screening. Cells are the most critical and variable reagent for cell-based high-throughput screening. The robustness of robotic screenin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24786fb2d833330c7e6aca75d8e7b6d3
https://pubmed.ncbi.nlm.nih.gov/15798391
https://pubmed.ncbi.nlm.nih.gov/15798391
Autor:
Kuo-Chang Yin, Theresa Wood, Sang Na, Jules A. Shafer, Xiao-Ping Shi, Ming-Tain Lai, R. Bruce Register, Michael Platchek, Victor M. Garsky, Mohinder K. Sardana, Yue-Ming Li, Stephen J. Gardell, Elizabeth Chen, James Thiebeau, Mei-Jy Tang
Publikováno v:
The Journal of biological chemistry. 276(13)
beta-Secretase (BACE) is a membrane-bound aspartyl protease that cleaves the amyloid precursor protein to generate the N terminus of the amyloid beta peptide. BACE is expressed as a precursor protein containing Pre, Pro, protease, transmembrane, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b99ef0ddafdb65225a1dedba18a423
https://pubmed.ncbi.nlm.nih.gov/11266439
https://pubmed.ncbi.nlm.nih.gov/11266439
Autor:
Natalie Fursov, Mei Cong, Mark Federici, Michael Platchek, Peter Haytko, Roland Tacke, Thomas Livelli, Zhong Zhong
Publikováno v:
Assay & Drug Development Technologies; Feb2005, Vol. 3 Issue 1, p7-15, 9p
Application of Division Arrest Technology to Cell-Based HTS: Comparison with Frozen and Fresh Cells.
Autor:
Priya Kunapuli, Wei Zheng, Michael Weber, Kelli Solly, Rebecca Mull, Michael Platchek, Mei Cong, Zhong Zhong, Berta Strulovici
Publikováno v:
Assay & Drug Development Technologies; Feb2005, Vol. 3 Issue 1, p17-26, 10p