Zobrazeno 1 - 10
of 309
pro vyhledávání: '"Michael Groll"'
Publikováno v:
Advanced Science, Vol 11, Iss 22, Pp n/a-n/a (2024)
Abstract Pigments such as anthraquinones (AQs) and melanins are antioxidants, protectants, or virulence factors. AQs from the entomopathogenic bacterium Photorhabdus laumondii are produced by a modular type II polyketide synthase system. A key enzyme
Externí odkaz:
https://doaj.org/article/cce2ca2818f644139bcc9617ab6661b7
Autor:
Marietta S. Kaspers, Vivian Pogenberg, Christian Pett, Stefan Ernst, Felix Ecker, Philipp Ochtrop, Michael Groll, Christian Hedberg, Aymelt Itzen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Bacterial pathogens often make use of post-translational modifications to manipulate host cells. Legionella pneumophila, the causative agent of Legionnaires disease, secretes the enzyme AnkX that uses cytidine diphosphate-choline to post-tra
Externí odkaz:
https://doaj.org/article/24651e6d5226410298bde574e8f3a727
Autor:
Mona Baumgart, Michael Röpke, Max E. Mühlbauer, Sam Asami, Sophie L. Mader, Kai Fredriksson, Michael Groll, Ana P. Gamiz-Hernandez, Ville R. I. Kaila
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Buried charged networks in proteins are often important for their biological functionality and are believed to destabilise the protein fold. Here, the authors combine computational design, MD simulations, biophysical experiments, NMR and X-ray crysta
Externí odkaz:
https://doaj.org/article/0e77cdff4a874a32b8c39f0694e34a3c
Autor:
Melanie Baudrexl, Tarik Fida, Berkay Berk, Wolfgang H. Schwarz, Vladimir V. Zverlov, Michael Groll, Wolfgang Liebl
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Functional, biochemical, and preliminary structural properties are reported for three glycoside hydrolases of the recently described glycoside hydrolase (GH) family 159. The genes were cloned from the genomic sequences of different Caldicellulosirupt
Externí odkaz:
https://doaj.org/article/ab7d23403b10415891edc142e63d4a11
Autor:
Malvina Vogler, Ram Karan, Dominik Renn, Alexandra Vancea, Marie-Theres Vielberg, Stefan W. Grötzinger, Priya DasSarma, Shiladitya DasSarma, Jörg Eppinger, Michael Groll, Magnus Rueping
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Environments previously thought to be uninhabitable offer a tremendous wealth of unexplored microorganisms and enzymes. In this paper, we present the discovery and characterization of a novel γ-carbonic anhydrase (γ-CA) from the polyextreme Red Sea
Externí odkaz:
https://doaj.org/article/e2f6f414774945e7a023b8eb9c250b8a
Autor:
Pamina Kazman, Marie-Theres Vielberg, María Daniela Pulido Cendales, Lioba Hunziger, Benedikt Weber, Ute Hegenbart, Martin Zacharias, Rolf Köhler, Stefan Schönland, Michael Groll, Johannes Buchner
Publikováno v:
eLife, Vol 9 (2020)
In systemic light chain amyloidosis, an overexpressed antibody light chain (LC) forms fibrils which deposit in organs and cause their failure. While it is well-established that mutations in the LC’s VL domain are important prerequisites, the mechan
Externí odkaz:
https://doaj.org/article/7abca921f3e74dd78a0b33e60cc6f525
Autor:
Bastian Bräuning, Eva Bertosin, Florian Praetorius, Christian Ihling, Alexandra Schatt, Agnes Adler, Klaus Richter, Andrea Sinz, Hendrik Dietz, Michael Groll
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The Yersinia YaxAB system is a pore-forming toxin of so far unknown structure. Here authors present X-ray and cryo-EM to structures of individual subunits and of the YaxAB pore complex, and find that YaxA binds to membranes first and recruits YaxB fo
Externí odkaz:
https://doaj.org/article/b58d61f8141a4986b198653b2a2a0a9c
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
The catalytic activity of dioxygenase AsqJ is strictly relying on the methylation of quinolone substrates. Here, the authors apply molecular simulations, X-ray crystallography and in vitro biochemical studies to the engineering of dioxygenase AsqJ wi
Externí odkaz:
https://doaj.org/article/774a7713e65b4a69a86781a9fc86afcc
Autor:
Rudolf Wachtel, Bastian Bräuning, Sophie L. Mader, Felix Ecker, Ville R. I. Kaila, Michael Groll, Aymelt Itzen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The bacterial protease GtgE is involved in the establishment of Salmonellosis. Here the authors provide a structural and biochemical analysis of GtgE that sheds light on the molecular mechanisms of reprogramming infected host cells via site-specific
Externí odkaz:
https://doaj.org/article/b1737a5a57314d0189c7e7ac298e8846
Autor:
Eva M. Huber, Michael Groll
Publikováno v:
Cells, Vol 10, Iss 8, p 1929 (2021)
At the heart of the ubiquitin–proteasome system, the 20S proteasome core particle (CP) breaks down the majority of intracellular proteins tagged for destruction. Thereby, the CP controls many cellular processes including cell cycle progression and
Externí odkaz:
https://doaj.org/article/976f9ef364a54cf69756b11066499194