Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Michael D. Serby"'
Publikováno v:
Expert Opinion on Therapeutic Patents. 18:989-998
Background: Ghrelin is an endogenous ligand of the growth hormone secretagogue receptor (GHS-R) that functions as a short-term meal initiator and a long-term energy balance regulator. Antagonizing GHS-R could be a method to treat obesity. Objective:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d400cdda90314341ddffb4e25788e3e
https://doi.org/10.1517/13543776.18.9.989
https://doi.org/10.1517/13543776.18.9.989
Autor:
Christine A. Collins, Mei Liu, Hongyu Zhao, Rich S. Janis, Heidi S. Camp, Teresa K. Surowy, Gang Liu, Bo Liu, Nelson Lissa T, Harriet T. Smith, Ning Cao, Tom S. Suhar, Michael D. Serby, Zhili Xin, Hing L. Sham, Bruce G. Szczepankiewicz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4298-4302
A series of structurally novel stearoyl-CoA desaturase1 (SCD1) inhibitors has been identified via molecular scaffold manipulation. Preliminary structure-activity relationship (SAR) studies led to the discovery of potent, and orally bioavailable piper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055af8cecf34aa640b107ce18838c33e
https://doi.org/10.1016/j.bmcl.2008.06.088
https://doi.org/10.1016/j.bmcl.2008.06.088
Autor:
Teresa K. Surowy, Hing L. Sham, Tom S. Suhar, Ning Cao, Michael D. Serby, Heidi S. Camp, Christine A. Collins, Hongyu Zhao, Gang Liu, Harriet T. Smith
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3388-3391
A series of novel stearoyl-CoA desaturase 1 (SCD1) inhibitors were identified by scaffold design based on known SCD1 inhibitors. Large structural changes were made leading to multiple analogs with comparable or improved potency. This approach is valu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d07ddf5293e2d8a201e8adcc12320f
https://doi.org/10.1016/j.bmcl.2007.03.099
https://doi.org/10.1016/j.bmcl.2007.03.099
Autor:
Ning Cao, Zhili Xin, Jennifer L. Freeman, Bo Liu, Teresa K. Surowy, Rich S. Janis, Hongyu Zhao, Christine A. Collins, Ruojing Yang, Michael D. Serby, Heidi S. Camp, Tom S. Suhar, Philip R. Kym, David W A Beno, Lynch John K, Gang Liu, Steven P Cepa, Harriet T. Smith, Hing L. Sham, Joel A. Krauser
Publikováno v:
Journal of Medicinal Chemistry. 50:3086-3100
Stearoyl-CoA desaturase 1 (SCD1) catalyzes the committed step in the biosynthesis of monounsaturated fatty acids from saturated, long-chain fatty acids. Studies with SCD1 knockout mice have established that these animals are lean and protected from l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42af278811a494ed64ae2d19357a5e53
https://doi.org/10.1021/jm070219p
https://doi.org/10.1021/jm070219p
Autor:
David W A Beno, Gang Liu, Zhili Xin, James S. Polakowski, Nathan L. Lubbers, Bo Liu, Mei Liu, James M. Trevillyan, Hongyu Zhao, Michael D. Serby, Hing L. Sham, D. L. Widomski
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:495-500
The hemodynamic effects of a series of potent and selective 4-aminopyridine carboxamide-based pan-JNK inhibitors were assessed in an anesthetized rat model. The effects of these agents on mean arterial pressure, heart rate, cardiac contractility, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3186ce4d7b1307f25f3eb4289460d9f
https://doi.org/10.1016/j.bmcl.2006.10.013
https://doi.org/10.1016/j.bmcl.2006.10.013
Autor:
Hing L. Sham, Zhili Xin, Christi Kosogof, Terry Pederson, Hongyu Zhao, Cele Abad-Zapatero, Bo Liu, Michael D. Serby, Bruce G. Szczepankiewicz, Gang Liu, Cristina M. Rondinone, Nelson Lissa T, Deanna L. Haasch, Jill E. Clampit, Sanyi Wang, Rebecca J. Gum, James M. Trevillyan, Elizabeth H. Fry, Eric F. Johnson, Mei Liu
Publikováno v:
Journal of Medicinal Chemistry. 49:4455-4458
C-Jun NH2 terminal kinases (JNKs) are important cell signaling enzymes. JNK1 plays a central role in linking obesity and insulin resistance. JNK2 and JNK3 may be involved in inflammatory and neurological disorders, respectively. Small-molecule JNK in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc463ce3c72249463613b7043f83c6a3
https://doi.org/10.1021/jm060465l
https://doi.org/10.1021/jm060465l
Autor:
James M. Trevillyan, Elizabeth H. Fry, Eric F. Johnson, Chaohong Sun, Hing L. Sham, Charles W. Hutchins, Thomas H. Lubben, Bruce G. Szczepankiewicz, Edward T. Olejniczak, Michael A. Stashko, Cele Abad-Zapatero, Michael D. Serby, Rebecca J. Gum, Hongyu Zhao, Kristi Haskins, Zhili Xin, Bo Liu, Sarah A Dorwin, Jill E. Clampit, Nelson Lissa T, Gang Liu, Mei Liu, Christi Kosogof, Cristina M. Rondinone, Sanyi Wang, Deanna L. Haasch
Publikováno v:
Journal of Medicinal Chemistry. 49:3563-3580
The c-Jun N-terminal kinases (JNK-1, -2, and -3) are members of the mitogen activated protein (MAP) kinase family of enzymes. They are activated in response to certain cytokines, as well as by cellular stresses including chemotoxins, peroxides, and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5bb3bc96de29a87b4ec28bbfc5f96f
https://doi.org/10.1021/jm060199b
https://doi.org/10.1021/jm060199b
Autor:
Verlyn G. Schaefer, Michael D. Serby, Bo Liu, Christine A. Collins, H. Douglas Falls, Hongyu Zhao, Eugene N. Bush, Victoria Knourek-Segel, Theresa M Turner, Michael E. Brune, Gang Liu, Thomas A. Fey, Wiweka Kaszubska, Brian A. Droz, Christi Kosogof, Zhili Xin, David W A Beno, Robin Shapiro, Peer B. Jacobson, Bruce G. Szczepankiewicz, Mei Liu, Nelson Lissa T, Hing L. Sham
Publikováno v:
Journal of Medicinal Chemistry. 49:2568-2578
Ghrelin, a gut-derived orexigenic hormone, is an endogenous ligand of the growth hormone secretagogue receptor (GHS-R). Centrally administered ghrelin has been shown to cause hunger and increase food intake in rodents. Inhibition of ghrelin actions w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d352477e306be3be634175471489d0
https://doi.org/10.1021/jm0510934
https://doi.org/10.1021/jm0510934
Autor:
Thomas A. Fey, Brian A. Droz, Hing L. Sham, Christi Kosogof, Zhili Xin, Michael D. Serby, Kathy Sarris, H. Douglas Falls, Robin Shapiro, Hongyu Zhao, Michael E. Brune, Bo Liu, Ethan D. Hoff, Gang Liu, Charles W. Hutchins, Mei Liu, David W A Beno, Christopher A. Ogiela, Chun W. Lin, Eugene N. Bush, Bruce G. Szczepankiewicz, Peer B. Jacobson, Christine A. Collins, Victoria Knourek-Segel, Teresa M. Turner
Publikováno v:
Journal of medicinal chemistry. 49(15)
The discovery and pharmacological evaluation of potent, selective, and orally bioavailable growth hormone secretagogue receptor (GHS-R) antagonists are reported. Previously, 2,4-diaminopyrimidine-based GHS-R antagonists reported from our laboratories
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf86a3628feb1bafa985c9105c7d6f5
https://pubmed.ncbi.nlm.nih.gov/16854051
https://pubmed.ncbi.nlm.nih.gov/16854051
Autor:
Bo Liu, Zhili Xin, Michael D. Serby, Sanyi Wang, James M. Trevillyan, Michael A. Stashko, Jill E. Clampit, Gang Liu, Chaohong Sun, Thomas H. Lubben
Publikováno v:
The FASEB Journal. 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ea533bd10280247b98292461d7dea68
https://doi.org/10.1096/fasebj.20.4.a54-b
https://doi.org/10.1096/fasebj.20.4.a54-b