Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Michael Chlenov"'
Autor:
Igor Krupnik, Michael Chlenov
The Siberian Yupik people have endured centuries of change and repression, starting with the Russian Cossacks in 1648 and extending into recent years. The twentieth century brought especially formidable challenges, including forced relocation by Russ
Autor:
Deborah L. Smith, Lee E. Schechter, Michael Z. Kagan, Nicole T. Hatzenbuhler, Amedeo Arturo Failli, Deborah Ann Evrard, Zhang Minsheng, Jeannette Golembieski, Richard Eric Mewshaw, Margaret Lai, Steven Edward Lenicek, Michael Chlenov, Jean Sze, Terrance H. Andree, Dahui Zhou, Annmarie L. Saab, Geoffrey Hornby, Reinhardt Bernhard Baudy, Boyd L. Harrison, Uresh Shantilal Shah, Kelly Sullivan
Publikováno v:
Journal of Medicinal Chemistry. 51:6980-7004
Novel compounds combining a 5-HT 1A moiety (3-aminochroman scaffold) and a 5-HT transporter (indole analogues) linked through a common basic nitrogen via an alkyl chain attached at the 1- or 3-position of the indole were evaluated for dual affinity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0888e59808afb3d9088f68290cf3d60e
https://doi.org/10.1021/jm8007097
https://doi.org/10.1021/jm8007097
Autor:
Michael Chlenov, S. Melnikov, R.C. Bernotas, Michael Z. Kagan, A. Greenfield, Jonathan Laird Gross
Publikováno v:
Journal of Chromatography A. 1194:80-89
The retention behavior of primary, secondary and tertiary amines was studied using normal-phase-HPLC on silica, diol, and cyano stationary phases. Several classes of amines, including benzylamines, anilines, ephedrines, tryptamines, and azatryptamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d89db015ffb01ba79e476b695aa8696
https://doi.org/10.1016/j.chroma.2008.04.052
https://doi.org/10.1016/j.chroma.2008.04.052
Autor:
Li Di, Leonard A. McDonald, Mairead Young, Lisa Nogle, Dahui Zhou, Brian L. Marquez, Mei-Yi Zhang, William L. Watts, Frank E. Koehn, Alvin C. Bach, Yanxuan Cai, Alan G. Sutherland, Neal Byrne, Guy T. Carter, Michael Z. Kagan, Edward H. Kerns, Mark Tischler, Carl J. Balibar, Oliver J. McConnell, Igor Goljer, Gerhard Schlingmann, Yanan He, Don Herold, Douglas M. Ho, Michael Chlenov, Christopher J. Petucci, R. Thomas Williamson, Gregory J. Tawa, Yingru Zhang, Vasilios Marathias, Christina M. Kraml, Kristi Fan
Publikováno v:
Chirality. 19:658-682
The application of Chiral Technology, or the (extensive) use of techniques or tools for the determination of absolute stereochemistry and the enantiomeric or chiral separation of racemic small molecule potential lead compounds, has been critical to s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76974c7b396b4bbc3b5ccb44e18646ca
https://doi.org/10.1002/chir.20399
https://doi.org/10.1002/chir.20399
Publikováno v:
Journal of Chromatography A. 1120:82-88
Mixtures of hexane-like ethoxynonafluorobutane with alcohols were used as MS-friendly mobile phases for separation and efficient detection of non-UV-active enantiomers and diastereomers using normal-phase HPLC-APCI-MS. Racemic muscone, camphorsulfona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b28199c408e1f7be670af10e9451c1b
https://doi.org/10.1016/j.chroma.2005.12.109
https://doi.org/10.1016/j.chroma.2005.12.109
Publikováno v:
Journal of Chromatography A. 1033:321-331
We have reported recently that high-speed normal-phase (NP) HPLC separations of a broad range of organic compounds can be performed on cyano columns using gradients of methanol in hexane-like solvent—ethoxynonafluorobutane (ENFB), available commerc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e7a2c6b2774c083ab5476fec5374f14
https://doi.org/10.1016/j.chroma.2004.01.042
https://doi.org/10.1016/j.chroma.2004.01.042
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 27:1817-1834
A novel approach to auto‐purification of a wide variety of organic compounds is described. It is based on normal‐phase (NP) gradient high performance liquid chromatography (HPLC), performed on a 2 × 15 cm cyano column hyphenated with atmospheric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5752b9d923a03975426d702dcd88e564
https://doi.org/10.1081/jlc-120038770
https://doi.org/10.1081/jlc-120038770
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:941-944
A series of indane derivatives was synthesized and evaluated as mechanism-based inhibitors of dopamine β-hydroxylase (DBH).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89b24072c166cb11476ff087f01e11ac
https://doi.org/10.1016/0960-894x(95)00147-l
https://doi.org/10.1016/0960-894x(95)00147-l
Autor:
Boyd L. Harrison, Sie Yearl Chai, Gregory S. Friedrichs, Michael Chlenov, David L. Crandall, Hassan Mahmoud Elokdah, John Primeau
Publikováno v:
ChemInform. 33
Three novel metabolites of the angiotensin-II (A-II) receptor antagonist tasosartan have been identified in humans, and the syntheses and pharmacologic profiling of these metabolites are reported. Each metabolite bound the human A-II receptor with IC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61d6feee2c40fe0d92b097591453def4
https://doi.org/10.1002/chin.200245219
https://doi.org/10.1002/chin.200245219
Autor:
Zhongqi Shen, Geoffrey Hornby, Boyd L. Harrison, Nicole T. Hatzenbuhler, P. Siva Ramamoorthy, Deborah L. Smith, Wayne E. Childers, Kelly Sullivan, Michael Chlenov, Terrance H. Andree, Deborah Ann Evrard, Lee E. Schechter
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(1)
The structure–activity relationship (SAR) for three series of lactam-fused chroman derivatives possessing 3-amino substituents was evaluated. Many compounds exhibited affinities for both the 5-HT1A receptor and the 5-HT transporter. Compounds 45 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ffa3584c6f3a796ecb00de280080731
https://pubmed.ncbi.nlm.nih.gov/19932965
https://pubmed.ncbi.nlm.nih.gov/19932965