Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Michael Brunsteiner"'
Autor:
Arjun Rao, Tin M. Tunjic, Michael Brunsteiner, Michael Müller, Hosein Fooladi, Chiara Gasbarri, Noah Weber
Publikováno v:
Artificial Intelligence in the Life Sciences, Vol 3, Iss , Pp 100072- (2023)
Proximity-inducing compounds (PICs) are an emergent drug technology through which a protein of interest (POI), often a drug target, is brought into the vicinity of a second protein which modifies the POI’s function, abundance or localisation, givin
Externí odkaz:
https://doaj.org/article/f11773f1f2b14e7a98ec1230cb3e38bb
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 2058-2067 (2023)
Proteolysis targeting chimeras represent a class of drug molecules with a number of attractive properties, most notably a potential to work for targets that, so far, have been in-accessible for conventional small molecule inhibitors. Due to their dif
Externí odkaz:
https://doaj.org/article/8dda7351132d4685a58acee2be310ba4
Autor:
Jayant Iyer, Anjali Karn, Michael Brunsteiner, Andrew Ray, Adrian Davis, Isha Saraf, Amrit Paudel
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 848 (2023)
Oxidative degradation of drugs is one of the major routes of drug substance and drug product instability. Among the diverse routes of oxidation, autoxidation is considered to be challenging to predict and control, potentially due to the multi-step me
Externí odkaz:
https://doaj.org/article/4ca6497495894bff8569175abc19a971
Autor:
Elisabeth Fink, Michael Brunsteiner, Stefan Mitsche, Hartmuth Schröttner, Amrit Paudel, Sarah Zellnitz-Neugebauer
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 347 (2023)
Co-amorphous systems (COAMS) have raised increasing interest in the pharmaceutical industry, since they combine the increased solubility and/or faster dissolution of amorphous forms with the stability of crystalline forms. However, the choice of the
Externí odkaz:
https://doaj.org/article/0973c790c94149b094e60132fa7be065
Publikováno v:
Crystal Growth & Design. 23:2155-2168
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37b2516c86ba076def407de6c9eb7c7f
https://doi.org/10.1021/acs.cgd.2c01187
https://doi.org/10.1021/acs.cgd.2c01187
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1114 (2022)
The present study aimed to investigate methods for accelerating autoxidation of crystalline drugs in the solid-state that can potentially predict real−time stability. Solid droperidol (DPD) was selected as the model drug. A common free−radical in
Externí odkaz:
https://doaj.org/article/9d75cfa419e8480dbaa40e8b48047df5
Publikováno v:
Molecular Pharmaceutics. 20:1768-1778
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87ebb2fc94824433e42c1b1afa4a8f83
https://doi.org/10.1021/acs.molpharmaceut.2c00967
https://doi.org/10.1021/acs.molpharmaceut.2c00967
Proximity-inducing compounds (PICs) are an emergent drug technology through which a protein of interest (POI), often a drug target, is brought into the vicinity of a second protein which modifies the POI’s function, abundance or localisation, givin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72dc2d822ba4dcac066ca74b3c2ba05a
https://doi.org/10.1101/2022.06.03.494737
https://doi.org/10.1101/2022.06.03.494737
Autor:
Isha Saraf, Robert Roskar, Dattatray Modhave, Michael Brunsteiner, Anjali Karn, Dmytro Neshchadin, Georg Gescheidt, Amrit Paudel
Publikováno v:
Molecular pharmaceutics. 19(2)
In the present study, the oxidative degradation behavior of nifedipine (NIF) in amorphous solid dispersions (ASDs) prepared with poly(vinyl pyrrolidone) (PVP) with a short (K30) and a long (K90) chain length was investigated. The ASDs were prepared v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::187d20fff0802cbb692e1f219787e343
https://pubmed.ncbi.nlm.nih.gov/35060741
https://pubmed.ncbi.nlm.nih.gov/35060741
Publikováno v:
Pharmaceutics, Vol 10, Iss 3, p 101 (2018)
Amorphous solid dispersions are considered a promising formulation strategy for the oral delivery of poorly soluble drugs. The limiting factor for the applicability of this approach is the physical (in)stability of the amorphous phase in solid sample
Externí odkaz:
https://doaj.org/article/612f443cc561470b89e008ab4885c5fc