Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Michael Brenowitz"'
Autor:
Updesh Dixit, Savita Bhutoria, Xuhong Wu, Liming Qiu, Menachem Spira, Sheeba Mathew, Richard Harris, Lucas J. Adams, Sean Cahill, Rajiv Pathak, P. Rajesh Kumar, Minh Nguyen, Seetharama A. Acharya, Michael Brenowitz, Steven C. Almo, Xiaoqin Zou, Alasdair C. Steven, David Cowburn, Mark Girvin, Ganjam V. Kalpana
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
HIV-1 integrase (IN) binds the host factor INI1/SMARCB1, which is required at multiple stages of HIV-1 replication. Here, the authors show that the same IN residues are involved in INI1 and RNA binding and in influencing particle morphogenesis and su
Externí odkaz:
https://doaj.org/article/b8bafab2f92543e6a097c5d975bbcf2d
Autor:
Natalia G. Herrera, Nicholas C. Morano, Alev Celikgil, George I. Georgiev, Ryan J. Malonis, James H. Lee, Karen Tong, Olivia Vergnolle, Aldo B. Massimi, Laura Y. Yen, Alex J. Noble, Mykhailo Kopylov, Jeffrey B. Bonanno, Sarah C. Garrett-Thomson, David B. Hayes, Robert H. Bortz, Ariel S. Wirchnianski, Catalina Florez, Ethan Laudermilch, Denise Haslwanter, J. Maximilian Fels, M. Eugenia Dieterle, Rohit K. Jangra, Jason Barnhill, Amanda Mengotto, Duncan Kimmel, Johanna P. Daily, Liise-anne Pirofski, Kartik Chandran, Michael Brenowitz, Scott J. Garforth, Edward T. Eng, Jonathan R. Lai, Steven C. Almo
Publikováno v:
ACS Omega, Vol 6, Iss 1, Pp 85-102 (2020)
Externí odkaz:
https://doaj.org/article/8225fcf771154e9c93f8122d956b1bc4
Publikováno v:
MethodsX, Vol 8, Iss , Pp 101585- (2021)
DNA modifications are small covalent chemical groups that modify nucleotides to regulate DNA readout. Anomalous abundance and genome-wide localization of these modifications can negatively tune gene expression and propagate into unbalanced epigenetic
Externí odkaz:
https://doaj.org/article/16d6779d59b84a6590e5787db987fe67
Publikováno v:
Heliyon, Vol 5, Iss 12, Pp e03018- (2019)
Fusion of host and viral membranes is a crucial step during infection by enveloped viruses. In the structurally-defined “class I″ viral glycoproteins, the formation of a highly stable α-helical bundle by the ectodomain of the fusion subunit (e.g
Externí odkaz:
https://doaj.org/article/88e0fc27349c42b0b3da94250547d8be
Autor:
Christopher Warren, Tsutomu Matsui, Jerome M. Karp, Takashi Onikubo, Sean Cahill, Michael Brenowitz, David Cowburn, Mark Girvin, David Shechter
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The histone chaperone nucleoplasmin (Npm) stores histones H2A/H2B in the egg and embryo. Here, the authors use NMR to show that Npm’s intrinsically disordered tail domain controls histone binding at an acidic stretch, which is autoregulated through
Externí odkaz:
https://doaj.org/article/f49d4636918c4df182e86b219d111626
Autor:
Daria M. Shcherbakova, Mikhail Baloban, Alexander V. Emelyanov, Michael Brenowitz, Peng Guo, Vladislav V. Verkhusha
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Near-infrared fluorescent proteins are non-invasive probes for deep tissue imaging, but because of the dimeric state they perform poorly in protein labelling. Here, the authors engineered three spectrally resolvable monomeric near-infrared probes wit
Externí odkaz:
https://doaj.org/article/d65af6816dd54a51a577635c42aa4e40
Autor:
George M. Bou-Assaf, Ivan L. Budyak, Michael Brenowitz, Eric S. Day, David Hayes, John Hill, Ranajoy Majumdar, Paola Ringhieri, Peter Schuck, Jasper C. Lin
Publikováno v:
J Pharm Sci
Analytical ultracentrifugation (AUC) is a critical analytical tool supporting the development and manufacture of protein therapeutics. AUC is routinely used as an assay orthogonal to size exclusion chromatography for aggregate quantitation. This arti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e43b967f463b00c953dcfcd1b5533d9
https://europepmc.org/articles/PMC9232890/
https://europepmc.org/articles/PMC9232890/
Publikováno v:
MethodsX
MethodsX, Vol 8, Iss, Pp 101585-(2021)
MethodsX, Vol 8, Iss, Pp 101585-(2021)
DNA modifications are small covalent chemical groups that modify nucleotides to regulate DNA readout. Anomalous abundance and genome-wide localization of these modifications can negatively tune gene expression and propagate into unbalanced epigenetic
Autor:
Ganjam V. Kalpana, P. Rajesh Kumar, Steven C. Almo, Liming Qiu, Savita Bhutoria, Seetharama A. Acharya, Xiaoqin Zou, Sheeba Mathew, Lucas J. Adams, Richard Harris, Minh B. Nguyen, Updesh Dixit, Alasdair C. Steven, Xuhong Wu, Michael Brenowitz, Menachem Spira, Sean M. Cahill, Rajiv Pathak, Mark E. Girvin, David Cowburn
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
INI1/SMARCB1 binds to HIV-1 integrase (IN) through its Rpt1 domain and exhibits multifaceted role in HIV-1 replication. Determining the NMR structure of INI1-Rpt1 and modeling its interaction with the IN-C-terminal domain (IN-CTD) reveal that INI1-Rp
Autor:
Matt Law, Micheal Leser, Beatrix Ueberheide, Michael Brenowitz, Jonathan Pegan, Mohammed El Makkaoui, Michelle Khine, Jessica R. Chapman
Publikováno v:
Protein & Peptide Letters. 26:61-69
Background:For almost four decades, hydroxyl radical chemically generated by Fenton chemistry has been a mainstay for the oxidative ‘footprinting’ of macromolecules.Objective:In this article, we start by reviewing the application of chemical gene