Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Michael Azure"'
Publikováno v:
Nuclear Medicine and Biology. 43:391-396
Introduction The biodistribution and toxicology of a radiotherapeutic 212 Pb-trastuzumab conjugate were evaluated in nonhuman primates to meet the investigational new drug requirements prior to a phase I clinical trial in human subjects. Methods Male
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e63f4e11b8fb2a22d0334cdc672e4e7
https://doi.org/10.1016/j.nucmedbio.2016.04.001
https://doi.org/10.1016/j.nucmedbio.2016.04.001
Autor:
Ming Yu, Paula Silva, Mary Guaraldi, Mikhail Kagan, Jody Bozek, Simon P. Robinson, Michael Azure, David C. Onthank
Publikováno v:
Nuclear Medicine and Biology. 40:682-688
Introduction Released sympathetic neurotransmitter norepinephrine (NE) in the heart is cleared by neuronal uptake-1 and extraneuronal uptake-2 transporters. Cardiac uptake-1 and -2 expression varies among species, but the uptake-1 is the primary tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84fa4d8aa33e525a0ee9827fb6019573
https://doi.org/10.1016/j.nucmedbio.2013.03.003
https://doi.org/10.1016/j.nucmedbio.2013.03.003
Autor:
Julia M. Nielsen, Jennifer McDonald, Dmitry Zuev, Megan Hayes, Eric Wexler, Joanne J. Bronson, Henry Wong, Yu-Wen Li, Nicholas J. Lodge, John E. Macor, Jeffrey A. Deskus, James E. Grace, Hong Huang, Gail K. Mattson, Mary Guaraldi, Derek J. Denhart, David C. Onthank, Vijay T. Ahuja, Heidi Dulac, Michael F. Parker, Larisa Zueva, Douglas D. Dischino, Ronald J. Mattson, Thaddeus F. Molski, Michael Azure, Jonathan L. Ditta, Richard A. Hartz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6651-6655
Based on a favorable balance between CRF-R1 affinity, lipophilicity and metabolic stability, compound 10 was evaluated for potential development as PET radioligand. Compound [18F]10 was prepared with high radiochemical purity and showed promising bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e68bd4acd3bac602acb56267c782afe
https://doi.org/10.1016/j.bmcl.2012.08.112
https://doi.org/10.1016/j.bmcl.2012.08.112
Autor:
Lei Nie, Mahmoud Razavian, Lawrence W. Dobrucki, Sina Tavakoli, Simon P. Robinson, Albert J. Sinusas, Mehran M. Sadeghi, Jiasheng Zhang, Michael Azure
Publikováno v:
Journal of Nuclear Medicine. 52:1795-1802
Matrix metalloproteinases (MMPs) play a key role in the development of atherosclerosis and its complications. In vivo detection and quantification of MMP activation can help track the propensity to complications and response to therapy. We sought to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6e001234f010e57628bc7b1933da3f
https://doi.org/10.2967/jnumed.111.092379
https://doi.org/10.2967/jnumed.111.092379
Autor:
Mikhail Kagan, Carol Hui Hu, Thomas D. Harris, Megan Hayes, Padmaja Yalamanchili, Kelley Hanson, Ming Yu, Michael Azure, Ajay Purohit, Simon P. Robinson, Reinaldo Jones, Michael Cdebaca, Mary Guaraldi, Radeke Heike S, David S. Casebier
Publikováno v:
ACS Medicinal Chemistry Letters. 2:650-655
A series of potent and selective β1-adrenoreceptor ligands were identified (IC50 range, 0.04-0.25 nM; β1/β2 selectivity range, 65-450-fold), labeled with the PET radioisotope fluorine-18 and evaluated in normal Sprague-Dawley rats. Tissue distribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011363cd3addeb5ca8b13c5c85c2939e
https://doi.org/10.1021/ml1002458
https://doi.org/10.1021/ml1002458
Autor:
Nathan D. Wong, D. Scott Edwards, Jun Zhou, Michael Azure, Padmaja Yalamanchili, Satoshi Isobe, Dagmar Hartung, Junichi Yamazaki, Ai Fujimoto, Navneet Narula, Hendricus Boersma, Yuji Matsumoto, Jagat Narula, Artiom Petrov, Satoru Ohshima, Shinichiro Fujimoto
Publikováno v:
Journal of the American College of Cardiology. 52:1847-1857
Objectives This study sought to evaluate the feasibility of noninvasive detection of matrix metalloproteinase (MMP) activity in experimental atherosclerosis using technetium-99m–labeled broad matrix metalloproteinase inhibitor (MPI) and to determin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac82a2e60dba6ed332a01399c9b81049
https://doi.org/10.1016/j.jacc.2008.08.048
https://doi.org/10.1016/j.jacc.2008.08.048
Autor:
Mahesh Mistry, Padmaja Yalamanchili, Michael Azure, David S. Casebier, Ming Yu, Mikhail Kagan, Jody Bozek, Mary Guaraldi, Megan Hayes, Ajay Purohit, Jennifer McDonald, Radeke Heike S, Simon P. Robinson
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 36:63-72
Myocardial extractions of mitochondria complex I (MC-I) inhibitors were high and well correlated with flow. This study assessed the potential of MC-I inhibitors to be developed as myocardial perfusion imaging (MPI) agents.RP1003, RP1004, and RP1005 r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cec7c167295ee68df6d5494f92e035f
https://doi.org/10.1007/s00259-008-0909-8
https://doi.org/10.1007/s00259-008-0909-8
Autor:
Robinson Simon P, Heike S. Radeke, Kelley Hanson, Yu Ming, Ajay Purohit, Mikhail Kagan, Padmaja Yalamanchili, Fran Su, Michael Azure, Megan Hayes, Richard Benetti, David Casebier, Mary Guaraldi
Publikováno v:
Journal of Medicinal Chemistry. 51:2954-2970
A series of fluorinated pyridazinone derivatives with IC50 values ranging from 8 to 4000 nM for the mitochondrial complex 1 (MC1) have been prepared. Structure-activity relationship (SAR) assessment indicated preference of the fluorine label to be in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85efb56bb5eca380424d546c55bb8f18
https://doi.org/10.1021/jm701443n
https://doi.org/10.1021/jm701443n
Autor:
David S. Casebier, Mikhail Kagan, Ming Yu, Ajay Purohit, Padmaja Yalamanchili, Michael Azure, Eric Wexler, Jody Bozek, Radeke Heike S, Simon P. Robinson, Megan Hayes
Publikováno v:
Journal of Nuclear Cardiology. 14:782-788
Background BMS-747158-02 is a novel fluorine 18–labeled pyridazinone derivative designed for cardiac imaging. The uptake and retention mechanisms of F-18 BMS-747158-02 in cardiac myocytes were studied in vitro, and the biodistribution of F-18 BMS-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16be5df63f1caea06cf4f53f0173c72
https://doi.org/10.1016/j.nuclcard.2007.07.009
https://doi.org/10.1016/j.nuclcard.2007.07.009
Autor:
Ming Yu, David S. Casebier, Simon P. Robinson, Mikhail Kagan, Mary Guaraldi, Mahesh Mistry, Jennifer McDonald, Radeke Heike S, Kenneth Drew, Michael Azure, Ajay Purohit
Publikováno v:
Journal of Nuclear Cardiology. 14:789-798
Background BMS-747158-02 is a fluorine 18–labeled pyridaben derivative designed as a new myocardial perfusion imaging agent for use with positron emission tomography (PET). This study evaluated BMS-747158-02 in animal models of cardiac perfusion an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04fce39f7934baefc553ad2b3a08a1e9
https://doi.org/10.1016/j.nuclcard.2007.07.008
https://doi.org/10.1016/j.nuclcard.2007.07.008