Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Michael, Wermann"'
Autor:
Charles Bayly-Jones, Christopher J. Lupton, Claudia Fritz, Hariprasad Venugopal, Daniel Ramsbeck, Michael Wermann, Christian Jäger, Alex de Marco, Stephan Schilling, Dagmar Schlenzig, James C. Whisstock
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Meprin α is a proteolytic regulator of the extracellular matrix that forms enormous oligomeric filaments of unknown purpose. Here, the authors determine by cryo-EM the structural basis of the meprin supercoiled filament and further characterise a sm
Externí odkaz:
https://doaj.org/article/38630ad799064ddaba5722e41c9934b6
Autor:
Victoria Ilse, Rebekka Scholz, Michael Wermann, Marcel Naumann, Martin S. Staege, Steffen Roßner, Holger Cynis
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8330 (2022)
The triggers for the development of multiple sclerosis (MS) have not been fully understood to date. One hypothesis proposes a viral etiology. Interestingly, viral proteins from human endogenous retroviruses (HERVs) may play a role in the pathogenesis
Externí odkaz:
https://doaj.org/article/8be835a470b24ec6aec7f7f733c1ad54
Autor:
Miriam Linnert, Claudia Fritz, Christian Jäger, Dagmar Schlenzig, Daniel Ramsbeck, Martin Kleinschmidt, Michael Wermann, Hans-Ulrich Demuth, Christoph Parthier, Stephan Schilling
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5651 (2021)
The astacin protease Meprin β represents an emerging target for drug development due to its potential involvement in disorders such as acute and chronic kidney injury and fibrosis. Here, we elaborate on the structural basis of inhibition by a specif
Externí odkaz:
https://doaj.org/article/964848174b55420788f41c1e1affcdd6
Autor:
Janett Köppen, Anja Schulze, Lisa Machner, Michael Wermann, Rico Eichentopf, Max Guthardt, Angelika Hähnel, Jessica Klehm, Marie-Christin Kriegeskorte, Maike Hartlage-Rübsamen, Markus Morawski, Stephan von Hörsten, Hans-Ulrich Demuth, Steffen Roßner, Stephan Schilling
Publikováno v:
Molecules, Vol 25, Iss 3, p 580 (2020)
Alzheimer’s disease (AD) and Parkinson’s disease (PD), including dementia with Lewy bodies (DLB), account for the majority of dementia cases worldwide. Interestingly, a significant number of patients have clinical and neuropathological features o
Externí odkaz:
https://doaj.org/article/7da9d0773fc1416584614e4190644c3e
Autor:
Charles Bayly-Jones, Christopher J. Lupton, Claudia Fritz, Hariprasad Venugopal, Daniel Ramsbeck, Michael Wermann, Christian Jäger, Alex de Marco, Stephan Schilling, Dagmar Schlenzig, James C. Whisstock
The zinc-dependent metalloprotease meprin α is predominantly expressed in the brush border membrane of proximal tubules in the kidney and enterocytes in the small intestine and colon. In normal tissue homeostasis meprin α performs key roles in infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbbfde1089a3c0f2a89b17ff8ff31315
https://doi.org/10.1101/2022.03.13.484121
https://doi.org/10.1101/2022.03.13.484121
Autor:
Daniel Ramsbeck, Christoph Parthier, Hans-Ulrich Demuth, Stephan Schilling, Miriam Linnert, Michael Wermann, Martin Kleinschmidt, Claudia Fritz, Dagmar Schlenzig, Christian Jäger
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 5651, p 5651 (2021)
Volume 22
Issue 11
International Journal of Molecular Sciences, Vol 22, Iss 5651, p 5651 (2021)
Volume 22
Issue 11
The astacin protease Meprin β represents an emerging target for drug development due to its potential involvement in disorders such as acute and chronic kidney injury and fibrosis. Here, we elaborate on the structural basis of inhibition by a specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7feb43d2e744a3a88ac52c537574ae1
http://europepmc.org/articles/PMC8197800
http://europepmc.org/articles/PMC8197800
Autor:
Stephan Schilling, Michael Wermann, Miriam Linnert, Martin Kleinschmidt, Claudia Fritz, Hans-Ulrich Demuth, Christian Jäger, Daniel Ramsbeck, Dagmar Schlenzig
The astacin protease Meprin β represents an emerging target for drug development due to its potential involvement in disorders such as acute and chronic kidney injury and fibrosis. Here, we elaborate on the structural basis of inhibition by a specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ec0001f5a64dcafc469baf1f2cb3c4
Autor:
Mirko Buchholz, Holger Cynis, Hans-Ulrich Demuth, Claudia Spahn, Ulrike Zeitschel, Daniel Ramsbeck, Michael Wermann, Maike Hartlage-Rübsamen, Steffen Roßner, Katja Menge, Dagmar Schlenzig, Anja Fothe, Stephan Schilling
Publikováno v:
Journal of Alzheimer's Disease. 66:359-375
The formation of amyloid-β (Aβ) peptides is causally involved in the development of Alzheimer's disease (AD). A significant proportion of deposited Aβ is N-terminally truncated and modified at the N-terminus by a pGlu-residue (pGlu-Aβ). These for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d94ec447859ba4fdfdc0d846dcf89a41
https://doi.org/10.3233/jad-171183
https://doi.org/10.3233/jad-171183
Publikováno v:
Protein Expression and Purification. 116:75-81
Human meprin β (h-meprin β), a single-zinc metalloendoprotease of the astacin family, is potentially involved in disorders such as fibrosis and Alzheimer’s disease. Here, we describe the expression of the enzyme in the yeast Pichia pastoris . The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abfd3153b739308bd4e57dc66e873001
https://doi.org/10.1016/j.pep.2015.08.001
https://doi.org/10.1016/j.pep.2015.08.001
Autor:
Angelika Hähnel, Janett Köppen, Hans-Ulrich Demuth, Stephan Schilling, Anja Schulze, Jessica Klehm, Michael Wermann
Publikováno v:
Alzheimer's & Dementia. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d685a9c6d78d9454c00f4c75e991c53
https://doi.org/10.1016/j.jalz.2017.07.618
https://doi.org/10.1016/j.jalz.2017.07.618