Zobrazeno 1 - 10
of 628
pro vyhledávání: '"Michael, Ward"'
Autor:
Hua Long, Adam Simmons, Arthur Mayorga, Brady Burgess, Tuan Nguyen, Balasubrahmanyam Budda, Anna Rychkova, Herve Rhinn, Ilaria Tassi, Michael Ward, Felix Yeh, Tina Schwabe, Robert Paul, Sara Kenkare-Mitra, Arnon Rosenthal
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-19 (2024)
Abstract Background Variants of the gene triggering receptor expressed on myeloid cells-2 (TREM2) increase the risk of Alzheimer’s disease (AD) and other neurodegenerative disorders. Signaling by TREM2, an innate immune receptor expressed by microg
Externí odkaz:
https://doaj.org/article/b420255d30c04ee396e2fe0de38486c6
Autor:
Avedis Assadour Ekmejian, Harry James Carpenter, Jonathan Laurence Ciofani, Benjamin Howard McIntosh Gray, Usaid Khalil Allahwala, Michael Ward, Javier Escaned, Peter James Psaltis, Ravinay Bhindi
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 19 (2024)
Coronary artery blood flow is influenced by various factors including vessel geometry, hemodynamic conditions, timing in the cardiac cycle, and rheological conditions. Multiple patterns of disturbed coronary flow may occur when blood flow separates f
Externí odkaz:
https://doaj.org/article/f60ba8c13a9f453ca414e16a9ee7ae2c
Autor:
Emily Phaboutdy, Michael Ward
Publikováno v:
Geospatial Health, Vol 19, Iss 1 (2024)
In June 2022, an exotic pest of the European honeybee (Apis mellifera), the varroa mite (Varroa destructor), was detected in surveillance hives at the Port of Newcastle, New South Wales (NSW). Previously, Australia remained the only continent free of
Externí odkaz:
https://doaj.org/article/dad70e80acc94324b1ebf50e36c2985c
Autor:
Yoko Marwidi, Hoang-Oanh B. Nguyen, David Santos, Tenzin Wangzor, Sumita Bhardwaj, Gabriel Ernie, Gregg Prawdzik, Garrett Lew, David Shivak, Michael Trias, Jada Padilla, Hung Tran, Kathleen Meyer, Richard Surosky, Alex Michael Ward
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101228- (2024)
Manufacturing of adeno-associated viruses (AAV) for gene and cell therapy applications has increased significantly and spurred development of improved mammalian and insect cell-based production systems. We developed a baculovirus-based insect cell pr
Externí odkaz:
https://doaj.org/article/cc8de2e15a6c4613942f48ea926bb8b5
Publikováno v:
International Journal of Cardiology: Heart & Vasculature, Vol 51, Iss , Pp 101384- (2024)
Background: CT coronary angiography (CTCA) is a guideline-endorsed assessment for patients with stable angina and suspected coronary disease. Although associated with excellent negative predictive value in ruling out obstructive coronary disease, the
Externí odkaz:
https://doaj.org/article/e02d36ba819040d1b1be892b9829d49c
Autor:
Michael Kurnellas, Ananya Mitra, Tina Schwabe, Robert Paul, Andrew E. Arrant, Erik D. Roberson, Michael Ward, Felix Yeh, Hua Long, Arnon Rosenthal
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-18 (2023)
Abstract Background Heterozygous loss-of-function mutations in the progranulin (PGRN) gene (GRN) cause a reduction in PGRN and lead to the development of frontotemporal dementia (FTD-GRN). PGRN is a secreted lysosomal chaperone, immune regulator, and
Externí odkaz:
https://doaj.org/article/b2df0fda23a94d45afa816e976160d6e
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 48, Iss , Pp 100956- (2024)
Introduction: Pleomorphic liposarcoma is a rare and aggressive subset of soft-tissue sarcomas with a high mortality burden. Local treatment largely consists of radiation therapy and wide surgical resection, but options for systemic therapy in the set
Externí odkaz:
https://doaj.org/article/1803ad9189514937a0f546329a12e63b
Autor:
Michael Ward, Lawrence P. Carter, Julie Y. Huang, Daniel Maslyar, Balasubrahmanyam Budda, Robert Paul, Arnon Rosenthal
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 10, Iss 1, Pp n/a-n/a (2024)
Abstract INTRODUCTION Heterozygous mutations in the GRN gene lead to reduced progranulin (PGRN) levels in plasma and cerebrospinal fluid (CSF) and are causative of frontotemporal dementia (FTD) with > 90% penetrance. Latozinemab is a human monoclonal
Externí odkaz:
https://doaj.org/article/dd511265638b4ca39288d8acd272d8a6
Autor:
Artur Meller, Michael Ward, Jonathan Borowsky, Meghana Kshirsagar, Jeffrey M. Lotthammer, Felipe Oviedo, Juan Lavista Ferres, Gregory R. Bowman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Cryptic pockets enable targeting of proteins currently considered undruggable because they lack pockets in their ground state structures. Here, the authors develop a graph neural network that accurately predicts cryptic pockets in static structures b
Externí odkaz:
https://doaj.org/article/41a3c6430fd3496cb5e06f23a4ce9bc3
Autor:
Aaron Held, Michelle Adler, Christine Marques, Charles Jourdan Reyes, Amey S. Kavuturu, Ana R.A.A. Quadros, I. Sandra Ndayambaje, Erika Lara, Michael Ward, Clotilde Lagier-Tourenne, Brian J. Wainger
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113046- (2023)
Summary: Motor neuron degeneration, the defining feature of amyotrophic lateral sclerosis (ALS), is a primary example of cell-type specificity in neurodegenerative diseases. Using isogenic pairs of induced pluripotent stem cells (iPSCs) harboring dif
Externí odkaz:
https://doaj.org/article/2a5b8930d521472090623e13da8df6d0