Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Michael, Vanlandewijck"'
Autor:
Elisa Vázquez-Liébanas, Giuseppe Mocci, Weihan Li, Bàrbara Laviña, Avril Reddy, Claire O’Connor, Natalie Hudson, Zaher Elbeck, Ioannis Nikoloudis, Konstantin Gaengel, Michael Vanlandewijck, Matthew Campbell, Christer Betsholtz, Maarja Andaloussi Mäe
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113911- (2024)
Summary: Claudin-5 (CLDN5) is an endothelial tight junction protein essential for blood-brain barrier (BBB) formation. Abnormal CLDN5 expression is common in brain disease, and knockdown of Cldn5 at the BBB has been proposed to facilitate drug delive
Externí odkaz:
https://doaj.org/article/d34577273d7342149fefcf704bebdf82
Autor:
Jeremiah Bernier-Latmani, Cristina Mauri, Rachel Marcone, François Renevey, Stephan Durot, Liqun He, Michael Vanlandewijck, Catherine Maclachlan, Suzel Davanture, Nicola Zamboni, Graham W. Knott, Sanjiv A. Luther, Christer Betsholtz, Mauro Delorenzi, Cathrin Brisken, Tatiana V. Petrova
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The molecular mechanisms ensuring the specialized structure of small intestinal villus tip blood vessels are incompletely understood. Here the authors show that ADAMTS18+ telocytes maintain a “just-right” level and location of VEGFA signaling on
Externí odkaz:
https://doaj.org/article/4f38232a5b4a4d508652a6e98af1cc5f
Autor:
Lars Muhl, Guillem Genové, Stefanos Leptidis, Jianping Liu, Liqun He, Giuseppe Mocci, Ying Sun, Sonja Gustafsson, Byambajav Buyandelger, Indira V. Chivukula, Åsa Segerstolpe, Elisabeth Raschperger, Emil M. Hansson, Johan L. M. Björkegren, Xiao-Rong Peng, Michael Vanlandewijck, Urban Lendahl, Christer Betsholtz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
To define and distinguish fibroblasts from vascular mural cells have remained challenging. Here, using single-cell RNA sequencing and tissue imaging, the authors provide a molecular basis for cell type classification and reveal inter- and intra-organ
Externí odkaz:
https://doaj.org/article/5f2bea014f994236b4d2abd38b628f2e
Autor:
Elin Almstedt, Ramy Elgendy, Neda Hekmati, Emil Rosén, Caroline Wärn, Thale Kristin Olsen, Cecilia Dyberg, Milena Doroszko, Ida Larsson, Anders Sundström, Marie Arsenian Henriksson, Sven Påhlman, Daniel Bexell, Michael Vanlandewijck, Per Kogner, Rebecka Jörnsten, Cecilia Krona, Sven Nelander
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
We lack effective treatment for half of children with high-risk neuroblastoma. Here, the authors introduce an algorithm that can predict the effect of interventions on gene expression signatures associated with high disease processes and risk, and id
Externí odkaz:
https://doaj.org/article/9eefbf3ff5bb4e6b9e9c8aacbd9a935c
Autor:
Dan Wu, Sailan Wang, Daniel V. Oliveira, Francesca Del Gaudio, Michael Vanlandewijck, Thibaud Lebouvier, Christer Betsholtz, Jian Zhao, ShaoBo Jin, Urban Lendahl, Helena Karlström
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 2 (2021)
Infantile myofibromatosis (IMF) is a benign tumor form characterized by the development of nonmetastatic tumors in skin, bone, muscle and sometimes viscera. Autosomal-dominant forms of IMF are caused by mutations in the PDGFRB gene, but a family carr
Externí odkaz:
https://doaj.org/article/d7896892823141bd8f49812317493396
Autor:
Menglan Xiang, Rubén Adrián Grosso, Akira Takeda, Junliang Pan, Tove Bekkhus, Kevin Brulois, Denis Dermadi, Sofia Nordling, Michael Vanlandewijck, Sirpa Jalkanen, Maria H. Ulvmar, Eugene C. Butcher
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2020)
Single-cell transcriptomics promise to revolutionize our understanding of the vasculature. Emerging computational methods applied to high-dimensional single-cell data allow integration of results between samples and species and illuminate the diversi
Externí odkaz:
https://doaj.org/article/3be8c70e7a1a4374997f565954bac0c0
Autor:
Eric Engelbrecht, Michel V Levesque, Liqun He, Michael Vanlandewijck, Anja Nitzsche, Hira Niazi, Andrew Kuo, Sasha A Singh, Masanori Aikawa, Kristina Holton, Richard L Proia, Mari Kono, William T Pu, Eric Camerer, Christer Betsholtz, Timothy Hla
Publikováno v:
eLife, Vol 9 (2020)
Despite the medical importance of G protein-coupled receptors (GPCRs), in vivo cellular heterogeneity of GPCR signaling and downstream transcriptional responses are not understood. We report the comprehensive characterization of transcriptomes (bulk
Externí odkaz:
https://doaj.org/article/2b95d8d5a479422885261efe96819fc7
Autor:
Milena Petkova, Marle Kraft, Simon Stritt, Ines Martinez-Corral, Henrik Ortsäter, Michael Vanlandewijck, Bojana Jakic, Eulàlia Baselga, Sandra D. Castillo, Mariona Graupera, Christer Betsholtz, Taija Mäkinen
Publikováno v:
Journal of Experimental Medicine. 220
Oncogenic mutations in PIK3CA, encoding p110α-PI3K, are a common cause of venous and lymphatic malformations. Vessel type–specific disease pathogenesis is poorly understood, hampering development of efficient therapies. Here, we reveal a new immun
Autor:
Lars Muhl, Guillem Genové, Stefanos Leptidis, Jianping Liu, Liqun He, Giuseppe Mocci, Ying Sun, Sonja Gustafsson, Byambajav Buyandelger, Indira V. Chivukula, Åsa Segerstolpe, Elisabeth Raschperger, Emil M. Hansson, Johan L. M. Björkegren, Xiao-Rong Peng, Michael Vanlandewijck, Urban Lendahl, Christer Betsholtz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/83c57908db664426b1e35cc001aef2b7
Autor:
Krishnapriya Loganathan, Ebtisam Salem Said, Emily Winterrowd, Martina Orebrand, Liqun He, Michael Vanlandewijck, Christer Betsholtz, Susan E Quaggin, Marie Jeansson
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0189433 (2018)
Presence of tubulointerstitial fibrosis is predictive of progressive decline in kidney function, independent of its underlying cause. Injury to the renal microvasculature is a major factor in the progression of fibrosis and identification of factors
Externí odkaz:
https://doaj.org/article/967dd5b803f1406c95f37cd90077f743