Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Michael, Sundström"'
Autor:
Filip Bergqvist, Yvonne Sundström, Ming-Mei Shang, Iva Gunnarsson, Ingrid E. Lundberg, Michael Sundström, Per-Johan Jakobsson, Louise Berg
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
We screened 57 chemical probes, high-quality tool compounds, and relevant clinically used drugs to investigate their effect on pro-inflammatory prostaglandin E2 (PGE2) production and interleukin-8 (IL-8) secretion in human whole blood. Freshly drawn
Externí odkaz:
https://doaj.org/article/a871bd4cbdc64a2aa5a43d6a1789ca85
Autor:
Suzanne Ackloo, Albert A. Antolin, Jose Manuel Bartolome, Hartmut Beck, Alex Bullock, Ulrich A. K. Betz, Jark Böttcher, Peter J. Brown, Menorca Chaturvedi, Alisa Crisp, Danette Daniels, Jan Dreher, Kristina Edfeldt, Aled M. Edwards, Ursula Egner, Jon Elkins, Christian Fischer, Tine Glendorf, Steven Goldberg, Ingo V. Hartung, Alexander Hillisch, Evert Homan, Stefan Knapp, Markus Köster, Oliver Krämer, Josep Llaveria, Uta Lessel, Sven Lindemann, Lars Linderoth, Hisanori Matsui, Maurice Michel, Florian Montel, Anke Mueller-Fahrnow, Susanne Müller, Dafydd R. Owen, Kumar Singh Saikatendu, Vijayaratnam Santhakumar, Wendy Sanderson, Cora Scholten, Matthieu Schapira, Sujata Sharma, Brock Shireman, Michael Sundström, Matthew H. Todd, Claudia Tredup, Jennifer Venable, Timothy M. Willson, Cheryl H. Arrowsmith
Publikováno v:
RSC Medicinal Chemistry.
Target 2035, an international federation of biomedical scientists from the public and private sectors, is leveraging ‘open’ principles to develop a pharmacological tool for every human protein.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3307d439e596fca276308b7255fe64f6
https://doi.org/10.1039/d2md00441k
https://doi.org/10.1039/d2md00441k
Autor:
Raina Seupel, Michael Sundström, Paul Brennan, Anke Mueller-Fahrnow, Andrea Introini, Adrian Carter
Publikováno v:
Target Discovery and Validation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdbe3e737b41cc610ac15c2b027ba593
https://doi.org/10.1002/9783527818242.ch1
https://doi.org/10.1002/9783527818242.ch1
Autor:
Iva Gunnarsson, Per-Johan Jakobsson, Louise Berg, Filip Bergqvist, Ingrid E. Lundberg, Ming-Mei Shang, Michael Sundström, Yvonne Sundström
We screened 57 chemical probes, high-quality tool compounds, and relevant clinically used drugs to investigate their effect on pro-inflammatory prostaglandin E2 (PGE2) production and interleukin-8 (IL-8) secretion in human whole blood. Freshly drawn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb48674be9b44219446f78919c48ca5
https://doi.org/10.1101/2019.12.30.890715
https://doi.org/10.1101/2019.12.30.890715
Autor:
M.H. Jensen, Irina Pozdnyakova, Lise Giehm, Erik Vernet, Jakob E. Rasmussen, Jens Berthelsen, Holger Grohganz, Huabing Wang, Bitten Plesner, Michael Sundström, Knud J. Jensen, Gina Popa, Hanne Mørck Nielsen, Marco van de Weert
Publikováno v:
Molecular Pharmaceutics. 13:1587-1598
PEGylation is the most widely used method to chemically modify protein biopharmaceuticals, but surprisingly limited public data is available on the biophysical effects of protein PEGylation. Here we report the first large-scale study, with site-speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db99d31ebf236aed25859442e6e0efa8
https://doi.org/10.1021/acs.molpharmaceut.6b00049
https://doi.org/10.1021/acs.molpharmaceut.6b00049
Autor:
Iva Gunnarsson, Yvonne Sundström, Per-Johan Jakobsson, Michael Sundström, Louise Berg, Filip Bergqvist, Ingrid E. Lundberg, Elena Ossipova, Johan Lengqvist
Publikováno v:
New players and novel targets in inflammation.
Background Systemic inflammatory diseases, such as systemic lupus erythematosus (SLE) and idiopathic inflammatory myositis (IIM), have largely unknown aetiology and represent a disease area with major unmet medical needs. Treatment often give a clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0409a4e65d79966d536c8ac25b942159
https://doi.org/10.1136/annrheumdis-2016-211050.48
https://doi.org/10.1136/annrheumdis-2016-211050.48
Autor:
Mats Wikström, Chiara Francavilla, Michael Sundström, Werner Streicher, Saverio Bellusci, Erik Vernet, Blagoy Blagoev, Jesper V. Olsen, Kristina B. Emdal, Kristoffer T.G. Rigbolt, Gianni Carraro, Ugo Cavallaro, Dorte B. Bekker-Jensen
Publikováno v:
Molecular Cell
Molecular Cell; Vol 51
Francavilla, C, Rigbolt, K T G, Emdal, K B, Carraro, G, Vernet, E, Bekker-Jensen, D B, Streicher, W, Wikström, M, Sundström, M, Bellusci, S, Cavallaro, U, Blagoev, B & Olsen, J V 2013, ' Functional Proteomics Defines the Molecular Switch Underlying FGF Receptor Trafficking and Cellular Outputs ', Molecular Cell, vol. 51, no. 6, pp. 707-722 . https://doi.org/10.1016/j.molcel.2013.08.002
Molecular Cell; Vol 51
Francavilla, C, Rigbolt, K T G, Emdal, K B, Carraro, G, Vernet, E, Bekker-Jensen, D B, Streicher, W, Wikström, M, Sundström, M, Bellusci, S, Cavallaro, U, Blagoev, B & Olsen, J V 2013, ' Functional Proteomics Defines the Molecular Switch Underlying FGF Receptor Trafficking and Cellular Outputs ', Molecular Cell, vol. 51, no. 6, pp. 707-722 . https://doi.org/10.1016/j.molcel.2013.08.002
The stimulation of fibroblast growth factor receptors (FGFRs) with distinct FGF ligands generates specific cellular responses. However, the mechanisms underlying this paradigm have remained elusive. Here, we show that FGF-7 stimulation leads to FGFR2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967230c6a34c24caadeb4235b79d61d7
Autor:
Jorg Gunter Grossmann, Frank Sobott, Declan A. Doyle, Michael Sundström, E. Papagrigoriou, Jonathan M. Elkins, Wen Hwa Lee, X. Yang, Carol V. Robinson
The seven members of the human 14-3-3 protein family regulate a diverse range of cell signaling pathways by formation of protein–protein complexes with signaling proteins that contain phosphorylated Ser/Thr residues within specific sequence motifs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d16921a532ebd9824e6a122cb3291a98
https://doi.org/10.1073/pnas.0605779103
https://doi.org/10.1073/pnas.0605779103
Autor:
Opher Gileadi, Udo Oppermann, Kathryn L. Kavanagh, John Offer, S.S. Ng, Michael Sundström, Johanna C. Scheinost, Tomasz Borowski, Michael A. McDonough, Ewa S. Pilka, Benoît M. R. Liénard, Frank von Delft, Pavel Savitsky, James E. Bray, Danica Butler, Christopher J. Schofield, Nathan R. Rose
Post-translational histone modification has a fundamental role in chromatin biology and is proposed to constitute a 'histone code' in epigenetic regulation. Differential methylation of histone H3 and H4 lysyl residues regulates processes including he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65e65c66328fd56f1cc462b7b2d12a6
https://ora.ox.ac.uk/objects/uuid:545da9d0-2eec-44f0-b3e8-fdd00c4f13cd
https://ora.ox.ac.uk/objects/uuid:545da9d0-2eec-44f0-b3e8-fdd00c4f13cd
Many protein kinases are validated intervention points for drug development, however active site similarities often lead to a lack of selectivity and unwanted side effects in the clinic. To address this issue, it is desirable to increase the number o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e12a5ca9661bbbb9a79ab124fa9da61
https://ora.ox.ac.uk/objects/uuid:3d6a6183-64f1-470a-a4a7-4ad2a7fba07d
https://ora.ox.ac.uk/objects/uuid:3d6a6183-64f1-470a-a4a7-4ad2a7fba07d