Zobrazeno 1 - 10
of 729
pro vyhledávání: '"Michael, Strupp"'
Autor:
Wolfgang H. Oertel, Annette Janzen, Martin T. Henrich, Fanni F. Geibl, Elisabeth Sittig, Sanne K. Meles, Giulia Carli, Klaus Leenders, Jan Booij, D. James Surmeier, Lars Timmermann, Michael Strupp
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Isolated REM Sleep Behavior Disorder (iRBD) is considered a prodrome of Parkinson’s disease (PD). We investigate whether the potentially disease-modifying compound acetyl-DL-leucine (ADLL; 5 g/d) has an effect on prodromal PD progression i
Externí odkaz:
https://doaj.org/article/8fa2d84467ba42578c7bc7fc4caacb16
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
Vestibular migraine (VM) and Menière’s disease (MD) are characterized by episodes of vertigo of similar duration. It is well known that differentiation between both diseases is not always possible based only on the patient history, physical examin
Externí odkaz:
https://doaj.org/article/2dbedaa8cb6b44c4bd89a54e289eaa29
Autor:
David Pellerin, Felix Heindl, Carlo Wilke, Matt C. Danzi, Andreas Traschütz, Catherine Ashton, Marie-Josée Dicaire, Alexanne Cuillerier, Giulia Del Gobbo, Kym M. Boycott, Jens Claassen, Dan Rujescu, Annette M. Hartmann, Stephan Zuchner, Bernard Brais, Michael Strupp, Matthis Synofzik
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105076- (2024)
Summary: Background: GAA-FGF14 disease/spinocerebellar ataxia 27B is a recently described neurodegenerative disease caused by (GAA)≥250 expansions in the fibroblast growth factor 14 (FGF14) gene, but its phenotypic spectrum, pathogenic threshold, a
Externí odkaz:
https://doaj.org/article/6a45cfb1de324e61a33fa2a7a9970a69
Autor:
Michael Strupp, Grant C. Churchill, Ivonne Naumann, Ulrich Mansmann, Amani Al Tawil, Anastasia Golentsova, Nicolina Goldschagg
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
BackgroundBetahistine was registered in Europe in the 1970s and approved in more than 80 countries as a first-line treatment for Menière's disease. It has been administered to more than 150 million patients. However, according to a Cochrane systemat
Externí odkaz:
https://doaj.org/article/461639fe2ac04f599647a45524256226
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
BackgroundDizziness is a common leading symptom in bilateral vestibulopathy (BVP) and functional dizziness (FD), with significant negative effects on functional ability and quality of life. Vertigoheel is a widely used non-prescription drug for the t
Externí odkaz:
https://doaj.org/article/72607696694b4f73a07d4baf33bbc7a2
Autor:
Melissa Antons, Magdalena Lindner, Eva Eilles, Lisa Günther, Astrid Delker, Christina Branner, Anja Krämer, Roswitha Beck, Rosel Oos, Max Wuehr, Sibylle Ziegler, Michael Strupp, Andreas Zwergal
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
IntroductionBetahistine is widely used for the treatment of various vestibular disorders. However, the approved oral administration route and maximum daily dose are evidently not effective in clinical trials, possibly due to a major first-pass metabo
Externí odkaz:
https://doaj.org/article/e3c08a6f394144e983a815b193937226
Autor:
Astros Th. Skuladottir, Gyda Bjornsdottir, Muhammad Sulaman Nawaz, Hannes Petersen, Solvi Rognvaldsson, Kristjan Helgi Swerford Moore, Pall I. Olafsson, Sigurður H. Magnusson, Anna Bjornsdottir, Olafur A. Sveinsson, Gudrun R. Sigurdardottir, Saedis Saevarsdottir, Erna V. Ivarsdottir, Lilja Stefansdottir, Bjarni Gunnarsson, Joseph B. Muhlestein, Kirk U. Knowlton, David A. Jones, Lincoln D. Nadauld, Annette M. Hartmann, Dan Rujescu, Michael Strupp, G. Bragi Walters, Thorgeir E. Thorgeirsson, Ingileif Jonsdottir, Hilma Holm, Gudmar Thorleifsson, Daniel F. Gudbjartsson, Patrick Sulem, Hreinn Stefansson, Kari Stefansson
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Astros Skuladottir et al. conducted a genome-wide association study on 48,072 vertigo cases and 894,541 controls from four populations with European ancestries. They identified six common variants associated with vertigo, thereby providing further in
Externí odkaz:
https://doaj.org/article/2f71e58c425346b081741b06b8a7001d
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/62a02bca260b4b46a7895a6e39f1fb84
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
BackgroundThere are many causes of episodes of vertigo and very few causes of episodes of changes in taste, and the combination of the two is very rare. Here, we describe a patient with recurrent short episodes of vertigo in combination with simultan
Externí odkaz:
https://doaj.org/article/fe4d3b0ec4334afcb6107cdac7f4a689
Autor:
Grant C. Churchill, Michael Strupp, Cailley Factor, Tatiana Bremova-Ertl, Mallory Factor, Marc C. Patterson, Frances M. Platt, Antony Galione
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Small changes to molecules can have profound effects on their pharmacological activity as exemplified by the addition of the two-carbon acetyl group to make drugs more effective by enhancing their pharmacokinetic or pharmacodynamic propertie
Externí odkaz:
https://doaj.org/article/8ec79fdb99cd4403ad6f39300b2c4f15