Výsledky vyhledávání - "Michael, Stenkilsson"

O26 Obeticholic acid improves experimental noninvasive markers of nonalcoholic steatohepatitis and advanced fibrosis: results from regenerate

Autor: Céline Fournier, Rohit Loomba, Reshma Shringarpure, Vlad Ratziu, Jérôme Boursier, Leigh MacConnell, Pierre Bedossa, Quentin M. Anstee, Zobair M. Younossi, Zachary Goodman, Mary E. Rinella, Arun J. Sanyal, S Al-Shamma, Luna Zaru, Stephen A. Harrison, Michael Stenkilsson, Aditya Venugopal

Publikováno v: Oral.

Introduction In the REGENERATE Month 18 interim analysis, obeticholic acid (OCA) treatment improved liver fibrosis in patients (pts) with nonalcoholic steatohepatitis (NASH). Noninvasive tools (NITs) were established to assess fibrosis stage (F) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b82cc153ce266de13e7318e2e4a5b6c1
https://doi.org/10.1136/gutjnl-2020-bsgcampus.26

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Obeticholic acid (OCA) improves experimental non-invasive markers of NASH and advanced fibrosis: results of a secondary analysis from the month-18 interim analysis of the REGENERATE study

Autor: L Mac Conell, Arun J. Sanyal, S Harrison, Aditya Venugopal, Quentin M. Anstee, P Bedossa, Z.Y. Younossi, Vlad Ratziu, J Schattenberg, Rohit Loomba, Luna Zaru, Reshma Shringarpure, Zachary Goodman, Jérôme Boursier, Mary E. Rinella, Céline Fournier, Michael Stenkilsson

Publikováno v: DGVS Digital: BEST OF DGVS.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab46b8a4b774242a6a33b5e1cd24186c
https://doi.org/10.1055/s-0040-1716157

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Obeticholic acid improves hepatic fibroinflammation as assessed by multiparametric magnetic resonance imaging: interim results of the regenerate trial

Autor: Rohit Loomba, Quentin Anstee, Stephen Harrison, Arun Sanyal, Vlad Ratziu, Zobair Younossi, Zachary Goodman, Pierre Bedossa, Rajarshi Banerjee, Michael Stenkilsson, Reshma Shringarpure, Luna Zaru, Aditya Venugopal, Leigh MacConell, Mary Rinella

Publikováno v: Journal of Hepatology. 73:S432-S433

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fca4f63de9b557df4d3aae8575691176
https://doi.org/10.1016/s0168-8278(20)31347-7

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Obeticholic acid improves experimental non-invasive markers of non-alcoholic steatohepatitis and advanced fibrosis: a secondary analysis of the phase 3 regenerate study

Autor: Jerome Boursier, Rohit Loomba, Quentin Anstee, Stephen Harrison, Arun Sanyal, Mary Rinella, Zobair Younossi, Zachary Goodman, Pierre Bedossa, Céline Fournier, Michael Stenkilsson, Reshma Shringarpure, Luna Zaru, Aditya Venugopal, Leigh MacConell, Vlad Ratziu

Publikováno v: Journal of Hepatology. 73:S54

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c29d743362ad709a92a8e1354a953b8
https://doi.org/10.1016/s0168-8278(20)30654-1

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334 OBETICHOLIC ACID IMPROVES EXPERIMENTAL NON-INVASIVE MARKERS OF NON-ALCOHOLIC STEATOHEPATITIS AND ADVANCED FIBROSIS; RESULTS OF A SECONDARY ANALYSIS FROM THE MONTH-18 INTERIM ANALYSIS OF THE REGENERATE STUDY

Autor: Quentin M. Anstee, Luna Zaru, Stephen A. Harrison, Céline Fournier, Zachary Goodman, Zobair M. Younossi, Pierre Bedossa, Arun J. Sanyal, Leigh MacConell, Vlad Ratziu, Michael Stenkilsson, Mary E. Rinella, Reshma Shringarpure, Jérôme Boursier, Rohit Loomba, Aditya Venugopal

Publikováno v: Gastroenterology. 158:S-1270

In the REGENERATE 18-month interim analysis, obeticholic acid (OCA) improved surrogate endpoints of liver fibrosis in patients with non-alcoholic steatohepatitis (NASH). New biomarker indices are being developed, including FibroMeter (FM), which is d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2796e5a3f8fb10e4d7cd31bf9c81b548
https://doi.org/10.1016/s0016-5085(20)33836-1

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Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3

Publikováno v: Journal of Medicinal Chemistry. 58:6784-6802

To realize the medicinal potential of peptide toxins, naturally occurring disulfide-rich peptides, as ion channel antagonists, more efficient pharmaceutical optimization technologies must be developed. Here, we show that the therapeutic properties of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ed4b88835ea36a6e04bf82dabb3f1f
https://doi.org/10.1021/acs.jmedchem.5b00495

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Peptide antagonists of the calcitonin gene-related peptide (CGRP) receptor with improved pharmacokinetics and pharmacodynamics

Autor: Eileen Johnson, Jerry Ryan Holder, Barton H. Manning, Licheng Shi, Kevin Salyers, Michael Stenkilsson, Colin V. Gegg, Marie E. Wright, George Doellgast, Kenneth D. Wild, Les P. Miranda

Publikováno v: Biopolymers. 100:422-430

Antagonism of the calcitonin gene-related peptide (CGRP) receptor may be a useful approach for migraine treatment. Selective PEGylated peptide antagonists to the CGRP receptor are described, derived from CGRP(8-37) with polymer derivatization at an e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ea37007135bf79af7cc0c5558bc94bf
https://doi.org/10.1002/bip.22270

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Peptide antagonists of the calcitonin gene-related peptide (CGRP) receptor with improved pharmacokinetics and pharmacodynamics

Autor: Les P, Miranda, Licheng, Shi, Jerry R, Holder, Marie, Wright, Colin V, Gegg, Eileen, Johnson, Kenneth, Wild, Michael, Stenkilsson, George, Doellgast, Barton H, Manning, Kevin, Salyers

Publikováno v: Biopolymers. 100(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a31b70dedf454786a35ff7d2eadd6074
https://pubmed.ncbi.nlm.nih.gov/23868210

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