Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Michael, Sinnreich"'
Autor:
Nitish Mittal, Meric Ataman, Lionel Tintignac, Daniel J. Ham, Lena Jörin, Alexander Schmidt, Michael Sinnreich, Markus A. Ruegg, Mihaela Zavolan
Publikováno v:
npj Regenerative Medicine, Vol 9, Iss 1, Pp 1-15 (2024)
Abstract Loss of protein homeostasis is one of the hallmarks of aging. As such, interventions that restore proteostasis should slow down the aging process and improve healthspan. Two of the most broadly used anti-aging interventions that are effectiv
Externí odkaz:
https://doaj.org/article/54bd417cb9164c0ba73083549ce6a246
Autor:
Denis Falcetta, Sandrine Quirim, Ilaria Cocchiararo, Florent Chabry, Marine Théodore, Adeline Stiefvater, Shuo Lin, Lionel Tintignac, Robert Ivanek, Jochen Kinter, Markus A. Rüegg, Michael Sinnreich, Perrine Castets
Publikováno v:
Skeletal Muscle, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Background Myotonic Dystrophy type I (DM1) is the most common muscular dystrophy in adults. Previous reports have highlighted that neuromuscular junctions (NMJs) deteriorate in skeletal muscle from DM1 patients and mouse models thereof. Howe
Externí odkaz:
https://doaj.org/article/af7b40e3a50f4837b9d4e0a855e85038
Autor:
Daniel J. Ham, Anastasiya Börsch, Kathrin Chojnowska, Shuo Lin, Aurel B. Leuchtman, Alexander S. Ham, Marco Thürkauf, Julien Delezie, Regula Furrer, Dominik Burri, Michael Sinnreich, Christoph Handschin, Lionel A. Tintignac, Mihaela Zavolan, Nitish Mittal, Markus A. Rüegg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
The anti-aging intervention calorie restriction (CR) is thought to act via the nutrient-sensing multiprotein complex mTORC1. Here the authors show that the mTORC1-inhibitor rapamycin and CR use largely distinct mechanisms to slow mouse muscle aging.
Externí odkaz:
https://doaj.org/article/444da6d136f045099a95445e8d650a04
Autor:
Daniel J. Ham, Anastasiya Börsch, Shuo Lin, Marco Thürkauf, Martin Weihrauch, Judith R. Reinhard, Julien Delezie, Fabienne Battilana, Xueyong Wang, Marco S. Kaiser, Maitea Guridi, Michael Sinnreich, Mark M. Rich, Nitish Mittal, Lionel A. Tintignac, Christoph Handschin, Mihaela Zavolan, Markus A. Rüegg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
mTORC1 expression is increased during ageing of muscle, and on the other hand, its activation promotes muscle hypertrophy. Here, the authors assess whether mTORC1 has positive or negative effects on ageing, and show that its long-term inhibition pres
Externí odkaz:
https://doaj.org/article/05a591c692df4b149c92e816d5905072
Autor:
Simona Reinhold, Desirée Yeginsoy, Alexa Hollinger, Atanas Todorov, Lionel Tintignac, Michael Sinnreich, Caroline Kiss, Caroline E. Gebhard, Balázs Kovács, Bianca Gysi, Lara Imwinkelried, Martin Siegemund
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-16 (2020)
Abstract Background Critically ill patients rapidly develop muscle wasting resulting in sarcopenia, long-term disability and higher mortality. Bolus nutrition (30–60 min period), whilst having a similar incidence of aspiration as continuous feeding
Externí odkaz:
https://doaj.org/article/96c7172ee70849a5a79b0c24743c31ba
Autor:
Nathalie Bouquier, Enora Moutin, Lionel A. Tintignac, Amandine Reverbel, Elodie Jublanc, Michael Sinnreich, Yan Chastagnier, Julien Averous, Pierre Fafournoux, Chiara Verpelli, Tobias Boeckers, Gilles Carnac, Julie Perroy, Vincent Ollendorff
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-17 (2020)
Abstract Background mTOR signaling is an essential nutrient and energetic sensing pathway. Here we describe AIMTOR, a sensitive genetically encoded BRET (Bioluminescent Resonance Energy Transfer) biosensor to study mTOR activity in living cells. Resu
Externí odkaz:
https://doaj.org/article/de858ec3955d4d94a438dc5be235f72e
Autor:
Alexander S. Ham, Kathrin Chojnowska, Lionel A. Tintignac, Shuo Lin, Alexander Schmidt, Daniel J. Ham, Michael Sinnreich, Markus A. Rüegg
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 1, Pp 259-273 (2020)
Abstract Background The balance between protein synthesis and degradation (proteostasis) is a determining factor for muscle size and function. Signalling via the mammalian target of rapamycin complex 1 (mTORC1) regulates proteostasis in skeletal musc
Externí odkaz:
https://doaj.org/article/463dbe3786a54576826b6dcaf9675034
Autor:
Perrine Castets, Nathalie Rion, Marine Théodore, Denis Falcetta, Shuo Lin, Markus Reischl, Franziska Wild, Laurent Guérard, Christopher Eickhorst, Marielle Brockhoff, Maitea Guridi, Chikwendu Ibebunjo, Joseph Cruz, Michael Sinnreich, Rüdiger Rudolf, David J. Glass, Markus A. Rüegg
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Denervation leads to muscle atrophy and neuromuscular endplate remodeling. Here, the authors show that a balanced activation of mTORC1 contributes to the dynamic regulation of autophagic flux in denervated muscle and that activation of PKB/Akt promot
Externí odkaz:
https://doaj.org/article/ad2327d58d6a49b7a54e496210a1a5f2
Autor:
Tim Sinnecker, Michaela Andelova, Michael Mayr, Stephan Rüegg, Michael Sinnreich, Juergen Hench, Stephan Frank, André Schaller, Christoph Stippich, Jens Wuerfel, Leo H. Bonati
Publikováno v:
BMC Neurology, Vol 19, Iss 1, Pp 1-8 (2019)
Abstract Background Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) is a mitochondrial cytopathy caused by mutations in mitochondrial DNA. Clinical manifestation is typically before the age of 40. Case presentation W
Externí odkaz:
https://doaj.org/article/7ba7b09b28f84a7ebb755024a8ba3df0
Autor:
Daniel J. Ham, Anastasiya Börsch, Kathrin Chojnowska, Shuo Lin, Aurel B. Leuchtmann, Alexander S. Ham, Marco Thürkauf, Julien Delezie, Regula Furrer, Dominik Burri, Michael Sinnreich, Christoph Handschin, Lionel A. Tintignac, Mihaela Zavolan, Nitish Mittal, Markus A. Rüegg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/c879cf0cbe364394806d8ecf246c6dbb