Zobrazeno 1 - 10 of 29 pro vyhledávání: '"Michael, Shusterman"'
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Akademický článek
Tankyrase inhibition sensitizes cells to CDK4 blockade.
Autor: Miguel Foronda, Yusuke Tarumoto, Emma M Schatoff, Benjamin I Leach, Bianca J Diaz, Jill Zimmerman, Sukanya Goswami, Michael Shusterman, Christopher R Vakoc, Lukas E Dow
Publikováno v: PLoS ONE, Vol 14, Iss 12, p e0226645 (2019)
Tankyrase (TNKS) 1/2 are positive regulators of WNT signaling by controlling the activity of the ß-catenin destruction complex. TNKS inhibitors provide an opportunity to suppress hyperactive WNT signaling in tumors, however, they have shown limited
Externí odkaz: https://doaj.org/article/fe38eb09ce16417485ff4b1070b18de3
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3
Data from Distinct Colorectal Cancer–Associated APC Mutations Dictate Response to Tankyrase Inhibition
Autor: Lukas E. Dow, Bianca J. Diaz, Alyna Katti, Benjamin I. Leach, Michael Shusterman, Miguel Foronda, Maria Paz Zafra, Sukanya Goswami, Emma M. Schatoff
The majority of colorectal cancers show hyperactivated WNT signaling due to inactivating mutations in the adenomatous polyposis coli (APC) tumor suppressor. Genetically restoring APC suppresses WNT and induces rapid and sustained tumor regression, im
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5abd6f8d58ad9ae339c892d786ec2b32
https://doi.org/10.1158/2159-8290.c.6547946.v1
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9
Racial Diversity Among Histology of Renal Cell Carcinoma at an Urban Medical Center
Autor: Juan Lin, Kevin Junmun Wong, Michael Shusterman, Sanjay Goel, Benjamin A. Gartrell, Abdissa Negassa
Publikováno v: Clinical Genitourinary Cancer. 19:e166-e170
Background Non-Hispanic blacks (NHB) with renal cell carcinoma (RCC) are more likely to have papillary RCC (pRCC) than non-Hispanic whites (NHW). Data on histologic subtypes in RCC in Hispanics (H) are also sparse. Previous studies have shown that pR
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c44eb15a4dee36921cdf85eed342a97
https://doi.org/10.1016/j.clgc.2020.12.010
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10
Analysis of the impact of eliminating bolus 5-fluorouracil in metastatic colorectal cancer
Autor: Chengwei Peng, Saad Saffo, Michael Shusterman, Daniel Jacob Becker, Jordan Berlin, Paul Eliezer Oberstein, Anil Nagar, Shun Yu
Publikováno v: Journal of Clinical Oncology. 41:59-59
59 Background: 5-Fluorouracil (5-FU) is a component of first-line treatment regimens for metastatic colorectal cancer (mCRC). Historically, 5-FU is administered as a bolus followed by an infusion. However, the bolus dose adds substantial toxicity and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb94e22414027375612ce33d46c47398
https://doi.org/10.1200/jco.2023.41.4_suppl.59
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