Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Michael, Seiler"'
Autor:
Michael Seiler, Andreas Knauft, Jann Jelto Gruben, Samson Frank, Andrea Barz, Jens Bliedtner, Andrés Fabián Lasagni
Publikováno v:
Materials, Vol 15, Iss 19, p 6572 (2022)
In recent years, the demand for highly integrated and lightweight components has been rising sharply, especially in plastics processing. One strategy for weight-saving solutions is the development of conductive tracks and layouts directly on the poly
Externí odkaz:
https://doaj.org/article/a2f40ea65f0544a994fb0952e3ecaca4
Autor:
Daniel Aird, Teng Teng, Chia-Ling Huang, Ermira Pazolli, Deepti Banka, Kahlin Cheung-Ong, Cheryl Eifert, Craig Furman, Zhenhua Jeremy Wu, Michael Seiler, Silvia Buonamici, Peter Fekkes, Craig Karr, James Palacino, Eunice Park, Peter G. Smith, Lihua Yu, Yoshiharu Mizui, Markus Warmuth, Agustin Chicas, Laura Corson, Ping Zhu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Small molecule modulators of RNA splicing have therapeutic potential in tumours bearing spliceosome mutations. Here, the authors identify BCL2 genes have differential sensitivities to SF3b-targeting splicing modulators and combination of SF3b-targeti
Externí odkaz:
https://doaj.org/article/3d3b4213a3e7400997cdfc63d11b14e8
Autor:
Konstantinos Tzelepis, Etienne De Braekeleer, Demetrios Aspris, Isaia Barbieri, M. S. Vijayabaskar, Wen-Hsin Liu, Malgorzata Gozdecka, Emmanouil Metzakopian, Hamish D. Toop, Monika Dudek, Samuel C. Robson, Francisco Hermida-Prado, Yu Hsuen Yang, Roya Babaei-Jadidi, Dimitrios A. Garyfallos, Hannes Ponstingl, Joao M. L. Dias, Paolo Gallipoli, Michael Seiler, Silvia Buonamici, Binje Vick, Andrew J. Bannister, Roland Rad, Rab K. Prinjha, John C. Marioni, Brian Huntly, Jennifer Batson, Jonathan C. Morris, Cristina Pina, Allan Bradley, Irmela Jeremias, David O. Bates, Kosuke Yusa, Tony Kouzarides, George S. Vassiliou
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
SRPK1, a kinase involved in splicing regulation, is a potential therapeutic target for AML patients. Here, the authors show that SRPK1 inhibition changes isoform levels of key epigenetic regulators, including BRD4, and it has anti-tumor effects speci
Externí odkaz:
https://doaj.org/article/1853a1ced0ff46dfaf75bec9896c8581
Autor:
Sunniva Stordal Bjørklund, Anshuman Panda, Surendra Kumar, Michael Seiler, Doug Robinson, Jinesh Gheeya, Ming Yao, Grethe I. Grenaker Alnæs, Deborah Toppmeyer, Margit Riis, Bjørn Naume, Anne-Lise Børresen-Dale, Vessela N. Kristensen, Shridar Ganesan, Gyan Bhanot
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Cancer cells can have different patterns of exon usage of individual genes when compared to normal tissue, suggesting that alternative splicing may play a role in shaping the tumor phenotype. The discovery and identification of gene variants
Externí odkaz:
https://doaj.org/article/04aae0fbd2df49be972341931d0609b5
Autor:
Manav Korpal, Xiaoling Puyang, Zhenhua Jeremy Wu, Roland Seiler, Craig Furman, Htoo Zarni Oo, Michael Seiler, Sean Irwin, Vanitha Subramanian, Jaya Julie Joshi, Chris K. Wang, Victoria Rimkunas, Davide Tortora, Hua Yang, Namita Kumar, Galina Kuznetsov, Mark Matijevic, Jesse Chow, Pavan Kumar, Jian Zou, Jacob Feala, Laura Corson, Ryan Henry, Anand Selvaraj, Allison Davis, Kristjan Bloudoff, James Douglas, Bernhard Kiss, Morgan Roberts, Ladan Fazli, Peter C. Black, Peter Fekkes, Peter G. Smith, Markus Warmuth, Lihua Yu, Ming-Hong Hao, Nicholas Larsen, Mads Daugaard, Ping Zhu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Muscle-invasive bladder cancer (MIBC) is a potentially lethal disease. Here the authors characterize diverse genetic alterations in MIBC that convergently lead to constitutive activation of PPARgamma/RXRalpha and result in immunosurveillance escape b
Externí odkaz:
https://doaj.org/article/96919909da284f8fa860db3ad18b5b3a
Autor:
Anant A. Agrawal, Michael Seiler, Lindsey T. Brinton, Rose Mantel, Rosa Lapalombella, Jennifer A. Woyach, Amy J. Johnson, Ping Zhu, Markus Warmuth, Lihua Yu, John C. Byrd, Peter G. Smith, James S. Blachly, Silvia Buonamici
Publikováno v:
Blood Advances, Vol 1, Iss 15, Pp 995-1000 (2017)
Externí odkaz:
https://doaj.org/article/b8e285b935314e6fbf1de8e2ffe50316
Autor:
Teng Teng, Jennifer HC Tsai, Xiaoling Puyang, Michael Seiler, Shouyong Peng, Sudeep Prajapati, Daniel Aird, Silvia Buonamici, Benjamin Caleb, Betty Chan, Laura Corson, Jacob Feala, Peter Fekkes, Baudouin Gerard, Craig Karr, Manav Korpal, Xiang Liu, Jason T. Lowe, Yoshiharu Mizui, James Palacino, Eunice Park, Peter G. Smith, Vanitha Subramanian, Zhenhua Jeremy Wu, Jian Zou, Lihua Yu, Agustin Chicas, Markus Warmuth, Nicholas Larsen, Ping Zhu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
A number of natural occurring small-molecule splicing modulators are known. Here, the authors combine chemogenomic, structural and biochemical methods and show that these compounds also target the spliceosome-associated protein PHF5A and propose a po
Externí odkaz:
https://doaj.org/article/bcd02552d59140f1871d75acbfffec14
Autor:
Tiina E. Kähkönen, Mari I. Suominen, Jenni H. E. Mäki-Jouppila, Jussi M. Halleen, Azusa Tanaka, Michael Seiler, Jenni Bernoulli
Publikováno v:
Journal of Immunology Research, Vol 2019 (2019)
Bone metastases are prevalent in many common cancers such as breast, prostate, and lung cancers, and novel therapies for treating bone metastases are needed. Human immune system-engrafted models are used in immuno-oncology (IO) studies for subcutaneo
Externí odkaz:
https://doaj.org/article/a35f2d7de1be424eb06ef17d42763d76
Autor:
Andrew A. Lane, H. Phillip Koeffler, Omar Abdel-Wahab, Francine Garnache-Ottou, Naveen Pemmaraju, Marina Konopleva, Henry Yang, Peter S. Hammerman, David M. Weinstock, Pier Paolo Piccaluga, Fabrice Jardin, Elizabeth A. Morgan, Abner Louissaint, Scott B. Lovitch, Silvia Buonamici, Michael Seiler, Sabeha Biichle, Fanny Angelot-Delettre, Yvonne Y. Li, Jia Li, Mahmoud Ghandi, Gabriel K. Griffin, Sunhee S. Kim, Justin Taylor, Lucia Cabal-Hierro, Christopher M. Kenyon, Christopher A.G. Booth, Vikas Madan, Sun Sook Chung, Katsuhiro Togami
Supplementary Figures S1-S8 with legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec467d08f4794ac5f85ded009f95a31
https://doi.org/10.1158/2159-8290.22541210.v1
https://doi.org/10.1158/2159-8290.22541210.v1
Autor:
Andrew A. Lane, H. Phillip Koeffler, Omar Abdel-Wahab, Francine Garnache-Ottou, Naveen Pemmaraju, Marina Konopleva, Henry Yang, Peter S. Hammerman, David M. Weinstock, Pier Paolo Piccaluga, Fabrice Jardin, Elizabeth A. Morgan, Abner Louissaint, Scott B. Lovitch, Silvia Buonamici, Michael Seiler, Sabeha Biichle, Fanny Angelot-Delettre, Yvonne Y. Li, Jia Li, Mahmoud Ghandi, Gabriel K. Griffin, Sunhee S. Kim, Justin Taylor, Lucia Cabal-Hierro, Christopher M. Kenyon, Christopher A.G. Booth, Vikas Madan, Sun Sook Chung, Katsuhiro Togami
Supplementary Tables 1-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4cf23850ead9d18cd22d06c66aecea
https://doi.org/10.1158/2159-8290.22541204
https://doi.org/10.1158/2159-8290.22541204