Synthesis and crystal structure of rac-2-(1,3-dioxoisoindolin-2-yl)ethyl 4-methyl-N-phenyl-N′-(triisopropylsilyl)benzenesulfondiimidoate: the first member of a new substance class

Autor: Erik Friedrich, Timo Heinrich, Lara Rosenberger, Mireille Krier, Stephanie Marek, Michael Reggelin

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 78, Iss 7, Pp 699-702 (2022)

The title compound {systematic name: rac-2-[7-methyl-4-(4-methylphenyl)-4-(phenylimino)-6,6-bis(propan-2-yl)-3-oxa-4λ6-thia-5-aza-6-silaoct-4-en-1-yl]-2,3-dihydro-1H-isoindole-1,3-dione}, C32H41N3O3SSi, was synthesized by desoxychlorination of 4-met

Externí odkaz: https://doaj.org/article/42bd0e77fc6b45179c1509ab4db6ecfc

A disintegrin derivative as a case study for PHIP labeling of disulfide bridged biomolecules

Autor: Max Fleckenstein, Kevin Herr, Franziska Theiß, Stephan Knecht, Laura Wienands, Martin Brodrecht, Michael Reggelin, Gerd Buntkowsky

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)

Abstract A specific labeling strategy for bioactive molecules is presented for eptifibatide (integrilin) an antiplatelet aggregation inhibitor, which derives from the disintegrin protein barbourin in the venom of certain rattlesnakes. By specifically

Externí odkaz: https://doaj.org/article/381cdd444ac74f3aa2340af417d60da8

Relative configuration of micrograms of natural compounds using proton residual chemical shift anisotropy

Autor: Nilamoni Nath, Juan Carlos Fuentes-Monteverde, Dawrin Pech-Puch, Jaime Rodríguez, Carlos Jiménez, Markus Noll, Alexander Kreiter, Michael Reggelin, Armando Navarro-Vázquez, Christian Griesinger

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)

Determination of 3D molecular structures remains challenging for natural products or organic compounds available in minute amounts. Here, the authors determine the structure of complex molecules, including few micrograms of briarane B-3 isolated from

Externí odkaz: https://doaj.org/article/91706d2613c64c70a003dfbe1d68564b

NMR-Based Configurational Assignments of Natural Products: How Floating Chirality Distance Geometry Calculations Simplify Gambling with 2N–1 Diastereomers

Autor: Stefan Immel, Matthias Köck, Michael Reggelin

Publikováno v: Journal of Natural Products. 85:1837-1849

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::195028c176548a156203a30a94568e9e
https://doi.org/10.1021/acs.jnatprod.2c00427

A novel strategy for site selective spin-labeling to investigate bioactive entities by DNP and EPR spectroscopy

Autor: Kevin Herr, Fabien Aussenac, Mark V. Höfler, Henrike Heise, Gerd Buntkowsky, Max Fleckenstein, Martin Brodrecht, Michael Reggelin, Torsten Gutmann

Publikováno v: Scientific reports 11(1), 13714 (2021). doi:10.1038/s41598-021-92975-6
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports

A novel specific spin-labeling strategy for bioactive molecules is presented for eptifibatide (integrilin) an antiplatelet aggregation inhibitor, which derives from the venom of certain rattlesnakes. By specifically labeling the disulfide bridge this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868988c0303addf7de7db18326b72558
http://tuprints.ulb.tu-darmstadt.de/24212/