Zobrazeno 1 - 10
of 464
pro vyhledávání: '"Michael, R H"'
Efficiently generating sufficient labeled data remains a major bottleneck in deep learning, particularly for image segmentation tasks where labeling requires significant time and effort. This study tackles this issue in a resource-constrained environ
Externí odkaz:
http://arxiv.org/abs/2401.14387
Publikováno v:
Cell Death and Disease, Vol 15, Iss 3, Pp 1-12 (2024)
Abstract Cellular responses to TNF are inherently heterogeneous within an isogenic cell population and across different cell types. TNF promotes cell survival by activating pro-inflammatory NF-κB and MAPK signalling pathways but may also trigger apo
Externí odkaz:
https://doaj.org/article/781dabfa9abf45a18d7b78ff53e0cc63
Autor:
Polly Downton, James S. Bagnall, Hazel England, David G. Spiller, Neil E. Humphreys, Dean A. Jackson, Pawel Paszek, Michael R. H. White, Antony D. Adamson
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Cells respond to inflammatory stimuli such as cytokines by activation of the nuclear factor-κB (NF-κB) signalling pathway, resulting in oscillatory translocation of the transcription factor p65 between nucleus and cytoplasm in some cell types. We i
Externí odkaz:
https://doaj.org/article/0ae9f541650a4de1829a089cf962e69c
Akademický článek
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The relationship between components of biochemical network and the resulting dynamics of the overall system is a key focus of computational biology. However, as these networks and resulting mathematical models are inherently complex and non-linear, t
Externí odkaz:
http://arxiv.org/abs/1403.1610
Autor:
Giorgos Minas, Dan J Woodcock, Louise Ashall, Claire V Harper, Michael R H White, David A Rand
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 8, p e1008076 (2020)
We consider how a signalling system can act as an information hub by multiplexing information arising from multiple signals. We formally define multiplexing, mathematically characterise which systems can multiplex and how well they can do it. While t
Externí odkaz:
https://doaj.org/article/04ee45a4dd7645fe931ba4f39c34efa6
Akademický článek
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Autor:
Hiroshi Momiji, Kirsty L Hassall, Karen Featherstone, Anne V McNamara, Amanda L Patist, David G Spiller, Helen C Christian, Michael R H White, Julian R E Davis, Bärbel F Finkenstädt, David A Rand
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 6, p e1007030 (2019)
Prolactin is a major hormone product of the pituitary gland, the central endocrine regulator. Despite its physiological importance, the cell-level mechanisms of prolactin production are not well understood. Having significantly improved the resolutio
Externí odkaz:
https://doaj.org/article/2bbb8bc2d77d4092b761e5d67d0c979f
Autor:
Louise E. King, Ricardo Rodriguez-Enriquez, Robert Pedley, Charlotte E. L. Mellor, Pengbo Wang, Egor Zindy, Michael R. H. White, Keith Brennan, Andrew P. Gilmore
Publikováno v:
Cell Death & Differentiation. 29:2262-2274
Apoptosis is regulated by interactions between the BH3-only and multi-domain Bcl-2 family proteins. These interactions are integrated on the outer mitochondrial membrane (OMM) where they set the threshold for apoptosis, known as mitochondrial priming
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f21e57fd062a503420047e54a7f479f
https://doi.org/10.1038/s41418-022-01013-z
https://doi.org/10.1038/s41418-022-01013-z
Autor:
Webb, Michael R. H., Ramsey, Codi A.
Publikováno v:
Journal of Australian Strength & Conditioning; 2024, Vol. 32 Issue 1, p63-81, 19p