Zobrazeno 1 - 10
of 194
pro vyhledávání: '"Michael, Poidinger"'
Autor:
Bernett Lee, Samantha Leeanne Cyrill, Wendy Lee, Rossella Melchiotti, Anand Kumar Andiappan, Michael Poidinger, Olaf Rötzschke
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-16 (2022)
Abstract Background Non-crossover (NCO) refers to a mechanism of homologous recombination in which short tracks of DNA are copied between homologue chromatids. The allelic changes are typically restricted to one or few SNPs, which potentially allow f
Externí odkaz:
https://doaj.org/article/6789065dca8a4f8b9135ff6219aef723
Autor:
Kia Joo Puan, Boris San Luis, Nurhashikin Yusof, Dilip Kumar, Anand Kumar Andiappan, Wendy Lee, Samanta Cajic, Dragana Vuckovic, Jing De Chan, Tobias Döllner, Han Wei Hou, Yunxuan Jiang, Chao Tian, the 23andMe Research Team, Erdmann Rapp, Michael Poidinger, De Yun Wang, Nicole Soranzo, Bernett Lee, Olaf Rötzschke
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Puan and San Luis et al. find that FUT6, encoding a fucosyltransferase, is required for the “rolling” behavior of certain white blood cells that enables them to move from blood vessels to tissues. They show that FUT6 deficiency leads to a loss of
Externí odkaz:
https://doaj.org/article/c143d737821c4b528b01c70d7893f2f4
Autor:
Karen Phaik Har Lim, Paul Milne, Michael Poidinger, Kaibo Duan, Howard Lin, Naomi McGovern, Harshal Abhyankar, Daniel Zinn, Thomas M. Burke, Olive S. Eckstein, Rikhia Chakraborty, Amel Sengal, Brooks Scull, Evan Newell, Miriam Merad, Kenneth L. McClain, Tsz-Kwong Man, Florent Ginhoux, Matthew Collin, Carl E. Allen
Publikováno v:
Blood Advances, Vol 4, Iss 1, Pp 87-99 (2020)
Abstract: Langerhans cell histiocytosis (LCH) is a myeloproliferative disorder that is characterized by the inflammatory lesions with pathogenic CD1a+CD207+ dendritic cells (DCs). BRAFV600E and other somatic activating MAPK gene mutations have been i
Externí odkaz:
https://doaj.org/article/c86f478e226541b0bac33e2a435850d6
Autor:
Christophe Carre, Glenn Wong, Vipin Narang, Crystal Tan, Joni Chong, Hui Xian Chin, Weili Xu, Yanxia Lu, Michelle Chua, Michael Poidinger, Paul Tambyah, Ma Nyunt, Tze Pin Ng, Daniel Larocque, Catherine Hessler, Nabil Bosco, Laurence Quemeneur, Anis Larbi
Publikováno v:
iScience, Vol 24, Iss 9, Pp 102970- (2021)
Summary: The elderly are an important target for influenza vaccination, and the determination of factors that underlie immune responsiveness is clinically valuable. We evaluated the immune and metabolic profiles of 205 elderly Singaporeans administer
Externí odkaz:
https://doaj.org/article/fa26c4ce8978498c97afc0e1f1f7416a
Autor:
Nuria Martinez, Catherine Y. Cheng, Natkunam Ketheesan, Aidan Cullen, Yuefeng Tang, Josephine Lum, Kim West, Michael Poidinger, David A. Guertin, Amit Singhal, Hardy Kornfeld
Publikováno v:
EBioMedicine, Vol 45, Iss , Pp 314-327 (2019)
Background: Mycobacterium tuberculosis has co-evolved with the human host, adapting to exploit the immune system for persistence and transmission. While immunity to tuberculosis (TB) has been intensively studied in the lung and lymphoid system, littl
Externí odkaz:
https://doaj.org/article/d7e6f9f991b54091830661097d95a4ef
Autor:
Weili Xu, Gianni Monaco, Eleanor Huijin Wong, Wilson Lek Wen Tan, Hassen Kared, Yannick Simoni, Shu Wen Tan, Wilson Zhi Yong How, Crystal Tze Ying Tan, Bernett Teck Kwong Lee, Daniel Carbajo, Srinivasan K.G., Ivy Chay Huang Low, Esther Wing Hei Mok, Shihui Foo, Josephine Lum, Hong Liang Tey, Wee Ping Tan, Michael Poidinger, Evan Newell, Tze Pin Ng, Roger Foo, Arne N. Akbar, Tamas Fülöp, Anis Larbi
Publikováno v:
EBioMedicine, Vol 39, Iss , Pp 44-58 (2019)
Background: Immune adaptation with aging is a major of health outcomes. Studies in humans have mainly focus on αβ T cells while γδ T cells have been neglected despite their role in immunosurveillance. We investigated the impact of aging on γδ T
Externí odkaz:
https://doaj.org/article/1de8ee1204604eb2a6fbd69c78a8cfae
Autor:
Jia Tong Loh, Thomas Jun Feng Lim, Kyoko Ikumi, Takuma Matoba, Baptiste Janela, Merry Gunawan, Tatsuya Toyama, Maegan Bunjamin, Lai Guan Ng, Michael Poidinger, Akimichi Morita, Florent Ginhoux, Sayuri Yamazaki, Kong-Peng Lam, I-hsin Su
Publikováno v:
iScience, Vol 10, Iss , Pp 23-39 (2018)
Summary: Ezh2, a well-established epigenetic repressor, can down-regulate leukocyte inflammatory responses, but its role in cutaneous health remains elusive. Here we demonstrate that Ezh2 controls cutaneous tolerance by regulating Langerhans cell (LC
Externí odkaz:
https://doaj.org/article/20cb73c3b3dc42908530f65184e738a4
Autor:
Sakshi Talwar, Manitosh Pandey, Chandresh Sharma, Rintu Kutum, Josephine Lum, Daniel Carbajo, Renu Goel, Michael Poidinger, Debasis Dash, Amit Singhal, Amit Kumar Pandey
Publikováno v:
mSystems, Vol 5, Iss 6 (2020)
ABSTRACT The worldwide increase in the frequency of multidrug-resistant and extensively drug-resistant cases of tuberculosis is mainly due to therapeutic noncompliance associated with a lengthy treatment regimen. Depending on the drug susceptibility
Externí odkaz:
https://doaj.org/article/0daf7a247fdd44aca1afc32136b9e8b7
Autor:
Clarice X. Lim, Bernett Lee, Olivia Geiger, Christina Passegger, Michaela Beitzinger, Johann Romberger, Anika Stracke, Christoph Högenauer, Anton Stift, Heribert Stoiber, Michael Poidinger, Armin Zebisch, Gunter Meister, Adam Williams, Richard A. Flavell, Jorge Henao-Mejia, Herbert Strobl
Publikováno v:
Cell Reports, Vol 30, Iss 11, Pp 3793-3805.e5 (2020)
Summary: DC-SIGN+ monocyte-derived dendritic cells (mo-DCs) play important roles in bacterial infections and inflammatory diseases, but the factors regulating their differentiation and proinflammatory status remain poorly defined. Here, we identify a
Externí odkaz:
https://doaj.org/article/25c5d2d6f07d462d88da33bb389312ce
Autor:
Xavier Camous, Lucian Visan, Crystal Tan Tze Ying, Brian Abel, Ma Shwe Zin Nyunt, Vipin Narang, Michael Poidinger, Christophe Carre, Sanie Sesay, Nabil Bosco, Nicolas Burdin, Paul Anantharajah Tambyah, Ng Tze Pin, Anis Larbi
Publikováno v:
Immunity & Ageing, Vol 15, Iss 1, Pp 1-6 (2018)
Abstract Improving influenza vaccine efficacy is a priority to reduce the burden of influenza-associated morbidity and mortality. By careful selection of individuals based on health we show sustained response to influenza vaccination in older adults.
Externí odkaz:
https://doaj.org/article/0bdf50c57c0f4cc9aceb3c147d95a7fd