Istradefylline protects from cisplatin-induced nephrotoxicity and peripheral neuropathy while preserving cisplatin antitumor effects

Autor: Edmone Dewaeles, Kévin Carvalho, Sandy Fellah, Jaewon Sim, Nihad Boukrout, Raphaelle Caillierez, Hariharan Ramakrishnan, Cynthia Van der Hauwaert, Jhenkruthi Vijaya Shankara, Nathalie Martin, Noura Massri, Agathe Launay, Joseph K. Folger, Clémentine de Schutter, Romain Larrue, Ingrid Loison, Marine Goujon, Matthieu Jung, Stéphanie Le Gras, Victoria Gomez-Murcia, Emilie Faivre, Julie Lemaire, Anne Garat, Nicolas Beauval, Patrice Maboudou, Viviane Gnemmi, Jean-Baptiste Gibier, Luc Buée, Corinne Abbadie, Francois Glowacki, Nicolas Pottier, Michael Perrais, Rodrigo A. Cunha, Jean-Sébastien Annicotte, Geoffroy Laumet, David Blum, Christelle Cauffiez

Publikováno v: The Journal of Clinical Investigation, Vol 132, Iss 22 (2022)

Cisplatin is a potent chemotherapeutic drug that is widely used in the treatment of various solid cancers. However, its clinical effectiveness is strongly limited by frequent severe adverse effects, in particular nephrotoxicity and chemotherapy-induc

Externí odkaz: https://doaj.org/article/f322febb20a9426fac11bb1c684e29af

MUC1 Mitigates Renal Injury and Inflammation in Endotoxin-Induced Acute Kidney Injury by Inhibiting the TLR4-MD2 Axis and Reducing Pro-inflammatory Macrophages Infiltration

Autor: Jean-Baptiste Gibier, Isabelle Van Seuningen, Thomas Swierczewski, Patrice Maboudou, Nicolas Pottier, Sébastien Aubert, Brigitte Hémon, François Glowacki, Michael Perrais, Marie Csanyi, Christelle Cauffiez, Viviane Gnemmi

Publikováno v: Shock
Shock, Lippincott, Williams & Wilkins, 2021, 56 (4), pp.629-638. ⟨10.1097/SHK.0000000000001742⟩
Shock, 2021, 56 (4), pp.629-638. ⟨10.1097/SHK.0000000000001742⟩

Sepsis is the leading cause of acute kidney injury (AKI) in critical care patients. A cornerstone of sepsis-associated AKI is dysregulated inflammation driven by excessive activation of Toll-like receptor 4 (TLR4) pathway. MUC1, a membrane bound muci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ea352c4f09d4ef04ce0daf5d4a9074
https://hal.archives-ouvertes.fr/hal-03379151

miR-199a-5p Is upregulated during fibrogenic response to tissue injury and mediates TGFbeta-induced lung fibroblast activation by targeting caveolin-1.

Autor: Christian Lacks Lino Cardenas, Imène Sarah Henaoui, Elisabeth Courcot, Christoph Roderburg, Christelle Cauffiez, Sébastien Aubert, Marie-Christine Copin, Benoit Wallaert, François Glowacki, Edmone Dewaeles, Jadranka Milosevic, Julien Maurizio, John Tedrow, Brice Marcet, Jean-Marc Lo-Guidice, Naftali Kaminski, Pascal Barbry, Tom Luedde, Michael Perrais, Bernard Mari, Nicolas Pottier

Publikováno v: PLoS Genetics, Vol 9, Iss 2, p e1003291 (2013)

As miRNAs are associated with normal cellular processes, deregulation of miRNAs is thought to play a causative role in many complex diseases. Nevertheless, the precise contribution of miRNAs in fibrotic lung diseases, especially the idiopathic form (

Externí odkaz: https://doaj.org/article/3b350d17f2374efab178def6a83ac45b

[Fundamental aspects of oncogenesis]

Autor: Julie, Lemaire, Romain, Larrue, Michael, Perrais, Christelle, Cauffiez, Nicolas, Pottier

Publikováno v: Bulletin du cancer. 107(11)

Tumorigenesis has traditionally been considered as a multi-step process involving the activation of oncogenes as well as the inactivation of tumor suppressor genes. However, the mechanisms driving cancer initiation and progression are not restricted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f7263ee09ebec7f6e712f6ba6e5174cb
https://pubmed.ncbi.nlm.nih.gov/33039132

The Long Noncoding RNA DNM3OS Is a Reservoir of FibromiRs with Major Functions in Lung Fibroblast Response to TGF-β and Pulmonary Fibrosis

Autor: Nihal Martis, Virginie Magnone, Franck Broly, Bruno Crestani, Pascal Barbry, Nicolas Nottet, Elisabeth Courcot, Nicolas Pottier, Imène-Sarah Henaoui, Grégoire Savary, Nicolas Pons, Roger Rezzonico, Benoit Wallaert, Bernard Mari, Kevin Lebrigand, Agnès Paquet, Matthieu Buscot, Véronique Hofman, Michael Perrais, François Glowacki, Julien Fassy, Cynthia Van der Hauwaert, Paul Hofman, Charles-Hugo Marquette, Sylvie Leroy, Edmone Dewaeles, Georges Vassaux, Christian L. Lino Cardenas, Andreas Günther, Christelle Cauffiez, Saverio Bellusci, Serena Diazzi, Julie Lemaire, Thierry Brousseau, Laurent Plantier

Publikováno v: American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2019, 200 (2), pp.184-198. ⟨10.1164/rccm.201807-1237OC⟩
American Journal of Respiratory and Critical Care Medicine, 2019, 200 (2), pp.184-198. ⟨10.1164/rccm.201807-1237OC⟩

Rationale: Given the paucity of effective treatments for idiopathic pulmonary fibrosis (IPF), new insights into the deleterious mechanisms controlling lung fibroblast activation, the key cell type driving the fibrogenic process, are essential to deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e424679e109516d44a94df00182b5745
https://hal.archives-ouvertes.fr/hal-02413473