Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Michael, Oberst"'
Autor:
Patrick Freeman, Gaia Bellomo, Lucy Ireland, Maidinaimu Abudula, Teifion Luckett, Michael Oberst, Ruth Stafferton, Paula Ghaneh, Chris Halloran, Michael C. Schmid, Ainhoa Mielgo
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with an urgent unmet clinical need for new therapies. Using a combination of in vitro assays and in vivo preclinical models we demonstrate that therapeutic inhibition of the IGF si
Externí odkaz:
https://doaj.org/article/f2d2357408ad44d2ac20a8b008744c12
Autor:
Aung Naing, Jeffrey Infante, Sanjay Goel, Howard Burris, Chelsea Black, Shannon Marshall, Ikbel Achour, Susannah Barbee, Rena May, Chris Morehouse, Kristen Pollizzi, Xuyang Song, Keith Steele, Nairouz Elgeioushi, Farzana Walcott, Joyson Karakunnel, Patricia LoRusso, Amy Weise, Joseph Eder, Brendan Curti, Michael Oberst
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-15 (2019)
Abstract Background The safety, efficacy, pharmacokinetics, and pharmacodynamics of the anti-programmed cell death-1 antibody MEDI0680 were evaluated in a phase I, multicenter, dose-escalation study in advanced solid malignancies. Methods MEDI0680 wa
Externí odkaz:
https://doaj.org/article/cf9d82e0ebcd4aaeac76ef9a975cf4f7
Autor:
Darren J. Schofield, Jennifer Percival-Alwyn, Mateusz Rytelewski, John Hood, Raymond Rothstein, Leslie Wetzel, Kelly McGlinchey, Grace Adjei, Amanda Watkins, LeeAnn Machiesky, Weimin Chen, John Andrews, Maria Groves, Michelle Morrow, Ross A. Stewart, Andrew Leinster, Robert W. Wilkinson, Scott A. Hammond, Nadia Luheshi, Claire Dobson, Michael Oberst
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Preclinical studies of PD-L1 and CTLA-4 blockade have relied heavily on mouse syngeneic tumor models with intact immune systems, which facilitate dissection of immunosuppressive mechanisms in the tumor microenvironment. Commercially developed monoclo
Externí odkaz:
https://doaj.org/article/5b7084f79f5a4c06ad3eff39bdaa115c
Autor:
Zoë Weaver Ohler, Glenn Merlino, Chi-Ping Day, Robert Hollingsworth, Shyam K. Sharan, Terry Van Dyke, Patrick Raber, Ian M. Kaplan, Michael Oberst, Susana Hayes, Nathan Pate, Michelle Gumprecht, Abdalla Abdelmaksoud, Alan Kulaga, Devon Atkinson, Rajaa El Meskini
Maximum Productive frequency and clonality did not change significantly in blood or tumors post-anti-PD-L1 treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d518e9f188c0d673ce72f137f5ea16
https://doi.org/10.1158/1541-7786.22527215.v1
https://doi.org/10.1158/1541-7786.22527215.v1
Autor:
Zoë Weaver Ohler, Glenn Merlino, Chi-Ping Day, Robert Hollingsworth, Shyam K. Sharan, Terry Van Dyke, Patrick Raber, Ian M. Kaplan, Michael Oberst, Susana Hayes, Nathan Pate, Michelle Gumprecht, Abdalla Abdelmaksoud, Alan Kulaga, Devon Atkinson, Rajaa El Meskini
The top differentially expressed genes from Figure 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a6baae57bb3ad3f884901cb95c5f80
https://doi.org/10.1158/1541-7786.22527206.v1
https://doi.org/10.1158/1541-7786.22527206.v1
Autor:
Zoë Weaver Ohler, Glenn Merlino, Chi-Ping Day, Robert Hollingsworth, Shyam K. Sharan, Terry Van Dyke, Patrick Raber, Ian M. Kaplan, Michael Oberst, Susana Hayes, Nathan Pate, Michelle Gumprecht, Abdalla Abdelmaksoud, Alan Kulaga, Devon Atkinson, Rajaa El Meskini
TCR repertoire of control PBS-treated tumors indicates rich and even clone distribution.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44cd170d64176864933e1b1055126f00
https://doi.org/10.1158/1541-7786.22527212.v1
https://doi.org/10.1158/1541-7786.22527212.v1
Autor:
Zoë Weaver Ohler, Glenn Merlino, Chi-Ping Day, Robert Hollingsworth, Shyam K. Sharan, Terry Van Dyke, Patrick Raber, Ian M. Kaplan, Michael Oberst, Susana Hayes, Nathan Pate, Michelle Gumprecht, Abdalla Abdelmaksoud, Alan Kulaga, Devon Atkinson, Rajaa El Meskini
Only a subset of patients responds to immune checkpoint blockade (ICB) in melanoma. A preclinical model recapitulating the clinical activity of ICB would provide a valuable platform for mechanistic studies. We used melanoma tumors arising from an Hgf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4639533c8b37ba3a4cb0adaa78005164
https://doi.org/10.1158/1541-7786.c.6545363.v1
https://doi.org/10.1158/1541-7786.c.6545363.v1
Autor:
Zoë Weaver Ohler, Glenn Merlino, Chi-Ping Day, Robert Hollingsworth, Shyam K. Sharan, Terry Van Dyke, Patrick Raber, Ian M. Kaplan, Michael Oberst, Susana Hayes, Nathan Pate, Michelle Gumprecht, Abdalla Abdelmaksoud, Alan Kulaga, Devon Atkinson, Rajaa El Meskini
Additional representative anti-PD-L1 treatment effect on tumor growth in melanoma bearing mice (Study 3).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d66c541d2d1281df8913bff630dabc2
https://doi.org/10.1158/1541-7786.22527224
https://doi.org/10.1158/1541-7786.22527224
Autor:
Zoë Weaver Ohler, Glenn Merlino, Chi-Ping Day, Robert Hollingsworth, Shyam K. Sharan, Terry Van Dyke, Patrick Raber, Ian M. Kaplan, Michael Oberst, Susana Hayes, Nathan Pate, Michelle Gumprecht, Abdalla Abdelmaksoud, Alan Kulaga, Devon Atkinson, Rajaa El Meskini
Analysis of early tumor response to anti-PD-L1 treatment in Hgftg;Cdk4R24C/R24C melanoma bearing mice (Study 2).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03536d9aad72cec32f42371379fd33b7
https://doi.org/10.1158/1541-7786.22527227.v1
https://doi.org/10.1158/1541-7786.22527227.v1
Autor:
Zoë Weaver Ohler, Glenn Merlino, Chi-Ping Day, Robert Hollingsworth, Shyam K. Sharan, Terry Van Dyke, Patrick Raber, Ian M. Kaplan, Michael Oberst, Susana Hayes, Nathan Pate, Michelle Gumprecht, Abdalla Abdelmaksoud, Alan Kulaga, Devon Atkinson, Rajaa El Meskini
PD-L1 and FOXP3 expression in treated tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64621f08b34afeb9fd03b9bf312583ca
https://doi.org/10.1158/1541-7786.22527218
https://doi.org/10.1158/1541-7786.22527218