Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Michael, Nekorchuk"'
Autor:
Benjamin Varco-Merth, Morgan Chaunzwa, Derick M Duell, Alejandra Marenco, William Goodwin, Rachel Dannay, Michael Nekorchuk, Danica Shao, Kathleen Busman-Sahay, Christine M Fennessey, Lorna Silipino, Michael Hull, William J Bosche, Randy Fast, Kelli Oswald, Rebecca Shoemaker, Rachele Bochart, Rhonda MacAllister, Caralyn S Labriola, Jeremy V Smedley, Michael K Axthelm, Miles P Davenport, Paul T Edlefsen, Jacob D Estes, Brandon F Keele, Jeffrey D Lifson, Sharon R Lewin, Louis J Picker, Afam A Okoye
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012496 (2024)
Persistence of the rebound-competent viral reservoir (RCVR) within the CD4+ T cell compartment of people living with HIV remains a major barrier to HIV cure. Here, we determined the effects of the pan-lymphocyte-depleting monoclonal antibody (mAb) al
Externí odkaz:
https://doaj.org/article/98aa0bf5a0db40c1870449c56d1dca1f
Autor:
Sarah J Byrnes, Kathleen Busman-Sahay, Thomas A Angelovich, Skyler Younger, Sol Taylor-Brill, Michael Nekorchuk, Stephen Bondoc, Rachel Dannay, Margaret Terry, Catherine R Cochrane, Trisha A Jenkins, Michael Roche, Claire Deleage, Steven E Bosinger, Mirko Paiardini, Bruce J Brew, Jacob D Estes, Melissa J Churchill
Publikováno v:
PLoS Pathogens, Vol 19, Iss 3, p e1011290 (2023)
HIV-associated neurocognitive disorders (HAND) affect ~40% of virally suppressed people with HIV (PWH), however, the precise viral dependent and independent changes to the brain are unclear. Here we characterized the CNS reservoir and immune environm
Externí odkaz:
https://doaj.org/article/a8b2d780e7df44039d495cd700b5e282
Autor:
Malika Aid, Samuel J Vidal, Cesar Piedra-Mora, Sarah Ducat, Chi N Chan, Stephen Bondoc, Alessandro Colarusso, Carly E Starke, Michael Nekorchuk, Kathleen Busman-Sahay, Jacob D Estes, Amanda J Martinot, Dan H Barouch
Publikováno v:
PLoS Pathogens, Vol 18, Iss 4, p e1009990 (2022)
Syrian golden hamsters exhibit features of severe disease after SARS-CoV-2 WA1/2020 challenge and are therefore useful models of COVID-19 pathogenesis and prevention with vaccines. Recent studies have shown that SARS-CoV-2 infection stimulates type I
Externí odkaz:
https://doaj.org/article/16f32ce880f94c6d88ec71d28dacb9ec
Autor:
Mariane H. Schleimann, Maria-Louise Kobberø, Line K. Vibholm, Kathrine Kjær, Leila B. Giron, Kathleen Busman-Sahay, Chi Ngai Chan, Michael Nekorchuk, Manuel Schmidt, Burghardt Wittig, Tine E. Damsgaard, Peter Ahlburg, Michel B. Hellfritzsch, Kaja Zuwala, Frederik H. Rothemejer, Rikke Olesen, Phillipp Schommers, Florian Klein, Harsh Dweep, Andrew Kossenkov, Jens R. Nyengaard, Jacob D. Estes, Mohamed Abdel-Mohsen, Lars Østergaard, Martin Tolstrup, Ole S. Søgaard, Paul W. Denton
Publikováno v:
EBioMedicine, Vol 45, Iss , Pp 328-340 (2019)
Background: TLR9 agonists are being developed as immunotherapy against malignancies and infections. TLR9 is primarily expressed in B cells and plasmacytoid dendritic cells (pDCs). TLR9 signalling may be critically important for B cell activity in lym
Externí odkaz:
https://doaj.org/article/6617a90ba47a4cea9fc13ade7be6bc01
Autor:
Husam Taher, Eisa Mahyari, Craig Kreklywich, Luke S Uebelhoer, Matthew R McArdle, Matilda J Moström, Amruta Bhusari, Michael Nekorchuk, Xiaofei E, Travis Whitmer, Elizabeth A Scheef, Lesli M Sprehe, Dawn L Roberts, Colette M Hughes, Kerianne A Jackson, Andrea N Selseth, Abigail B Ventura, Hillary C Cleveland-Rubeor, Yujuan Yue, Kimberli A Schmidt, Jason Shao, Paul T Edlefsen, Jeremy Smedley, Timothy F Kowalik, Richard J Stanton, Michael K Axthelm, Jacob D Estes, Scott G Hansen, Amitinder Kaur, Peter A Barry, Benjamin N Bimber, Louis J Picker, Daniel N Streblow, Klaus Früh, Daniel Malouli
Publikováno v:
PLoS Pathogens, Vol 16, Iss 11, p e1008666 (2020)
Cytomegaloviruses (CMVs) are highly adapted to their host species resulting in strict species specificity. Hence, in vivo examination of all aspects of CMV biology employs animal models using host-specific CMVs. Infection of rhesus macaques (RM) with
Externí odkaz:
https://doaj.org/article/18b74986983c43189be2f692f0340704
Autor:
Aaron S. Devanathan, Nicole R. White, Yury Desyaterik, Gabriela De la Cruz, Michael Nekorchuk, Margaret Terry, Kathleen Busman-Sahay, Lourdes Adamson, Paul Luciw, Yuri Fedoriw, Jacob D. Estes, Elias P. Rosen, Angela D. M. Kashuba
Publikováno v:
Antimicrob Agents Chemother
Although current antiretroviral therapy (ART) has increased life expectancy, a cure for human immunodeficiency virus (HIV) remains elusive due to the persistence of the virus in tissue reservoirs. In the present study, we sought to elucidate the rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090f999b02b51bd92282670bbe0587cd
https://pubmed.ncbi.nlm.nih.gov/35856680
https://pubmed.ncbi.nlm.nih.gov/35856680
Autor:
Scott G. Hansen, Meaghan H. Hancock, Daniel Malouli, Emily E. Marshall, Colette M. Hughes, Kurt T. Randall, David Morrow, Julia C. Ford, Roxanne M. Gilbride, Andrea N. Selseth, Renee Espinosa Trethewy, Lindsey M. Bishop, Kelli Oswald, Rebecca Shoemaker, Brian Berkemeier, William J. Bosche, Michael Hull, Lorna Silipino, Michael Nekorchuk, Kathleen Busman-Sahay, Jacob D. Estes, Michael K. Axthelm, Jeremy Smedley, Danica Shao, Paul T. Edlefsen, Jeffrey D. Lifson, Klaus Früh, Jay A. Nelson, Louis J. Picker
Publikováno v:
Sci Immunol
The strain 68-1 rhesus cytomegalovirus (RhCMV)–based vaccine for simian immunodeficiency virus (SIV) can stringently protect rhesus macaques (RMs) from SIV challenge by arresting viral replication early in primary infection. This vaccine elicits un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0029e764e7ae4b9f7d96198478afd222
https://europepmc.org/articles/PMC9387538/
https://europepmc.org/articles/PMC9387538/
Autor:
John S. Burke, Noe B. Mercado, Jingyou Yu, Dan H. Barouch, Komlan Tevi, Vaneesha Ali, Shant H. Mahrokhian, Felix Nampanya, Sarah Ducat, Carly E. Starke, Ramya Nityanandam, Lisa H. Tostanoski, Blake M. Hauser, Linda M. Wrijil, Makda S. Gebre, Kathleen Busman-Sahay, Stephanie Fischinger, Dalia Benetiene, Stephen Bondoc, Maciel Porto, Cesar Piedra-Mora, Chi N. Chan, Jacob D. Estes, Jared Feldman, Frank Wegmann, Hanneke Schuitemaker, Douglas A. Lauffenburger, Mark G. Lewis, Roland Zahn, Gabriel Dagotto, Zijin Lin, Katherine McMahan, Caroline Atyeo, Laurent Pessaint, Timothy M. Caradonna, Galit Alter, Carolin Loos, Michael Nekorchuk, Catherine Jacob-Dolan, Esther A. Bondzie, Jerome Custers, Aaron G. Schmidt, Amanda J. Martinot, Hanne Leth Andersen
Publikováno v:
Nature Medicine
Coronavirus disease 2019 (COVID-19) in humans is often a clinically mild illness, but some individuals develop severe pneumonia, respiratory failure and death1–4. Studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dfb85cf87c4e42e071404f5f5b2f307
http://europepmc.org/articles/PMC7671939
http://europepmc.org/articles/PMC7671939
Autor:
Jenna Read, Colin T. King, Maria Pino, Mirko Paiardini, Heather Amrine-Madsen, Michael Nekorchuk, Chi Ngai Chan, Cristin M. Galardi, Hong Wang, James Schawalder, Katharine J. Bar, A. Alicia Koblansky, Colleen S. McGary, Kevin Nguyen, Jacob D. Estes, Sherrie Jean, Samuel L. M. Raines, Shane D. Falcinelli, Jeffrey D. Lifson, Shari Gordon, Luca Micci, Guido Silvestri, Andrew Sanderson, Justin L. Harper, Brian Johns, David Favre, Emily Lindemuth, Kathleen Busman-Sahay, Barbara Cervasi, David M. Margolis
Publikováno v:
Nature Medicine. 26:519-528
The primary human immunodeficiency virus (HIV) reservoir is composed of resting memory CD4+ T cells, which often express the immune checkpoint receptors programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte-associated protein 4 (CTLA-4),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::312fadfaa081c57663b7be6786d965d1
https://doi.org/10.1038/s41591-020-0782-y
https://doi.org/10.1038/s41591-020-0782-y
Autor:
Samuel J. Vidal, Jacob D. Estes, Dan H. Barouch, Michael Nekorchuk, Sarah Ducat, Cesar Piedra-Mora, Carly E. Starke, Colarusse A, Stephen Bondoc, Chi Ngai Chan, Kathleen Busman-Sahay, Aid M, Amanda J. Martinot
Syrian golden hamsters exhibit features of severe disease after SARS-CoV-2 challenge and are therefore useful models of COVID-19 pathogenesis and prevention with vaccines. Recent studies have shown that SARS-CoV-2 infection stimulates type I interfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36e960b326e6967817aefb37941e1739
https://doi.org/10.1101/2021.09.30.462514
https://doi.org/10.1101/2021.09.30.462514