Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Michael, Mosteller"'
Autor:
Claire Ambery, Elizabeth C. Harris, Misba Beerahee, Lynn D. Condreay, Soumitra Ghosh, Michael Mosteller
Publikováno v:
Pharmacogenetics and Genomics. 24:618-621
Pharmacokinetic variability in drug exposure is a concern for all compounds in development including those for the treatment of asthma and other respiratory disorders. Substantial variability in the oral clearance of GSK2190915, a 5-lipoxygenase-acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b35e5947aa7fd1f090ce3d6ec50fd532
https://doi.org/10.1097/fpc.0000000000000090
https://doi.org/10.1097/fpc.0000000000000090
Autor:
Louise Hosking, Michael Mosteller, Astrid Yeo, Soumitra Ghosh, Loretta Jacques, Deborah A. Meyers, Eugene R. Bleecker
Publikováno v:
Journal of Allergy and Clinical Immunology. 133:587-589
To The Editor: Inhaled corticosteroids (ICS) are the primary anti-inflammatory therapy for the control and management of asthma, but their effects are characterised by some inter-individual variability that may have a genetic basis1–4. Identificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::378e8667e60800f620037a064ae670e2
https://doi.org/10.1016/j.jaci.2013.08.024
https://doi.org/10.1016/j.jaci.2013.08.024
Autor:
Sandra L Close, Stuart Hobbs, Lawrence J. Lesko, Michael Pacanowski, Linda Surh, Arlene R Hughes, Susanne B. Haga, Nadine Cohen, Michael Mosteller, Scott Gottlieb, Marisa Papaluca-Amati, Myong-Jin Kim, Scott D. Patterson, Issam Zineh, Bryan Dechairo
Publikováno v:
Pharmacogenomics. 11:1637-1647
The 2010 US FDA–Drug Industry Association (DIA) Pharmacogenomics (PGx) Workshop follows a series that began in 2002 bringing together multidisciplinary experts spanning regulatory authorities, medical research, healthcare and industry. This report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc11c12f1a71f3198efeafc101270f09
https://doi.org/10.2217/pgs.10.138
https://doi.org/10.2217/pgs.10.138
Publikováno v:
Pharmacogenomics. 10:225-233
Abacavir hypersensitivity (ABC HSR) is a treatment-limiting adverse event associated with the use of the antiretroviral medicine, abacavir. The objective of the ABC HSR pharmacogenetics program was to identify clinically useful genetic risk factors t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4218863ac00878f2d79ba25019f872b
https://doi.org/10.2217/14622416.10.2.225
https://doi.org/10.2217/14622416.10.2.225
Autor:
Michael Mosteller, Li Li, Eric H. Lai, Silviu-Alin Bacanu, Allen D. Roses, Clive E. Bowman, Matthew R. Nelson, Margaret G. Ehm
Publikováno v:
The Pharmacogenomics Journal. 9:23-33
Adverse drug reactions (ADRs) have a major impact on patients, physicians, health care providers, regulatory agencies and pharmaceutical companies. Identifying the genetic contributions to ADR risk may lead to a better understanding of the underlying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d2dc75e6951e95f572209c4c1e64a2
https://doi.org/10.1038/tpj.2008.4
https://doi.org/10.1038/tpj.2008.4
Autor:
Eric H. Lai, Aruna Bansal, Michael Mosteller, Stephen Haneline, Kirstie Davies, Arlene R Hughes, Trevor Scott, Keith Nangle, Allen D. Roses, William Spreen, Cna study teams, Liling L. Warren
Publikováno v:
Pharmacogenomics. 5:203-211
Abacavir is an effective antiretroviral drug used to treat HIV-1 infection. Approximately 5% of patients treated with abacavir develop a hypersensitivity reaction that requires discontinuation of the drug. In an initial pharmacogenetic study conducte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8088b3442f1ca601d3a0645954fbe0dd
https://doi.org/10.1517/phgs.5.2.203.27481
https://doi.org/10.1517/phgs.5.2.203.27481
Autor:
Michael Mosteller, Matthew R. Nelson, Kay Murphy, Louise Hosking, Kijoung Song, Soumitra Ghosh, Judong Shen
Publikováno v:
Journal of Allergy and Clinical Immunology. 139:797-803.e7
Background Inhaled corticosteroids (ICSs) are considered the most effective anti-inflammatory therapy for asthma control and management; however, there is substantial treatment response variability. Objective We sought to identify genetic markers of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fea6fba80973371621d7444a5be828eb
https://doi.org/10.1016/j.jaci.2016.05.032
https://doi.org/10.1016/j.jaci.2016.05.032
Autor:
David A. Wilfret, Toshihiro Wajima, Paul M. Savina, Julie Borland, Louise Hosking, Stephen Castellino, Ivy Song, Yu Lou, Amanda Peppercorn, Stephen C. Piscitelli, Shuguang Chen, Phyllis Guta, Michael Mosteller, Justin P. Rubio, David S. Wagner
Publikováno v:
European Journal of Clinical Pharmacology
Purpose Dolutegravir (DTG) is an unboosted, integrase inhibitor for the treatment of HIV infection. Two studies evaluated the effects of efavirenz (EFV) and tipranavir/ritonavir (TPV/r) on DTG pharmacokinetics (PK) in healthy subjects. Methods The fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::984af936c038d65ca650a963a795dfcd
https://pubmed.ncbi.nlm.nih.gov/25146692
https://pubmed.ncbi.nlm.nih.gov/25146692
Autor:
Michael Mosteller, Hector Ortega, Lynn D. Condreay, Lingkang Huang, Sandra W. Stinnett, Beena T. Koshy, Wayne Anderson
Publikováno v:
Annals of allergy, asthmaimmunology : official publication of the American College of Allergy, Asthma,Immunology. 110(6)
Identifying genetic markers of susceptibility to exacerbations may improve patient management, decrease morbidity, and lead to drug development.To assess whether genetic markers associated with severe asthma exacerbations in previous reports are asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f9b790a0e2029b7e7c7d81bff2517d
https://pubmed.ncbi.nlm.nih.gov/23706709
https://pubmed.ncbi.nlm.nih.gov/23706709
Publikováno v:
D37. SYSTEMS BIOLOGY AND MOLECULAR PROFILING IN PULMONARY HEALTH AND DISEASE.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6afc6af7ad783f09f8226475b1951d82
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6026
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6026