Výsledky vyhledávání - "Michael, Melcher"

Akademický článek

Analysis of biomass productivity and physiology of Nitrososphaera viennensis grown in continuous culture

Autor: Michael Melcher, Logan H. Hodgskiss, Mohammad Anas Mardini, Christa Schleper, Simon K.-M. R. Rittmann

Publikováno v: Frontiers in Microbiology, Vol 14 (2023)

Microbial ammonia oxidation is the first and usually rate limiting step in nitrification and is therefore an important step in the global nitrogen cycle. Ammonia-oxidizing archaea (AOA) play an important role in nitrification. Here, we report a compr

Externí odkaz: https://doaj.org/article/6d050059bb694df6a8083dcb9088b2af

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Akademický článek

Predicting favorable landing pads for targeted integrations in Chinese hamster ovary cell lines by learning stability characteristics from random transgene integrations

Autor: Heena Dhiman, Marguerite Campbell, Michael Melcher, Kevin D. Smith, Nicole Borth

Publikováno v: Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 3632-3648 (2020)

Chinese Hamster Ovary (CHO) cell lines are considered to be the preferred platform for the production of biotherapeutics, but issues related to expression instability remain unresolved. In this study, we investigated potential causes for an unstable

Externí odkaz: https://doaj.org/article/d1b0e2b0e5be40d29efe6b4a57cfd5c5

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Akademický článek

Nitrogen Isotope Fractionation During Archaeal Ammonia Oxidation: Coupled Estimates From Measurements of Residual Ammonium and Accumulated Nitrite

Autor: Maria Mooshammer, Ricardo J. E. Alves, Barbara Bayer, Michael Melcher, Michaela Stieglmeier, Lara Jochum, Simon K.-M. R. Rittmann, Margarete Watzka, Christa Schleper, Gerhard J. Herndl, Wolfgang Wanek

Publikováno v: Frontiers in Microbiology, Vol 11 (2020)

The naturally occurring nitrogen (N) isotopes, 15N and 14N, exhibit different reaction rates during many microbial N transformation processes, which results in N isotope fractionation. Such isotope effects are critical parameters for interpreting nat

Externí odkaz: https://doaj.org/article/f48d9417b4264a8c859942ae7fbb4e39

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Parsimonious statistical learning models for low-flow estimation

Autor: Johannes Laimighofer, Michael Melcher, Gregor Laaha

Publikováno v: Hydrology and Earth System Sciences, Vol 26, Pp 129-148 (2022)

Statistical learning methods offer a promising approach for low-flow regionalization. We examine seven statistical learning models (Lasso, linear, and nonlinear-model-based boosting, sparse partial least squares, principal component regression, rando

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9defebc830179ba7bcfa97bcf2b1efd0
https://hess.copernicus.org/articles/26/129/2022/hess-26-129-2022.pdf

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Akademický článek

Candidatus Nitrosocaldus cavascurensis, an Ammonia Oxidizing, Extremely Thermophilic Archaeon with a Highly Mobile Genome

Autor: Sophie S. Abby, Michael Melcher, Melina Kerou, Mart Krupovic, Michaela Stieglmeier, Claudia Rossel, Kevin Pfeifer, Christa Schleper

Publikováno v: Frontiers in Microbiology, Vol 9 (2018)

Ammonia oxidizing archaea (AOA) of the phylum Thaumarchaeota are widespread in moderate environments but their occurrence and activity has also been demonstrated in hot springs. Here we present the first enrichment of a thermophilic representative wi

Externí odkaz: https://doaj.org/article/a8dc6fb521e6475d9adb57ebbb65a884

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Technology transfer of a monitoring system to predict product concentration and purity of biopharmaceuticals in real‐time during chromatographic separation

Autor: Anna Christler, Theresa Scharl, Michael Melcher, Johannes Köppl, Anne Tscheließnig, Cabir Toy, Astrid Dürauer, Alois Jungbauer, Dominik G. Sauer

Publikováno v: Biotechnology and Bioengineering

Technological developments require the transfer to their location of application to make use of them. We describe the transfer of a real‐time monitoring system for lab‐scale preparative chromatography to two new sites where it will be used and de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c01d3eeb848f75ef6fad5b05663b7c
http://europepmc.org/articles/PMC8518415

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Low flow estimation beyond the mean – expectile loss and extreme gradient boosting for spatio-temporal low flow prediction in Austria

Autor: Johannes Laimighofer, Michael Melcher, Gregor Laaha

Accurate predictions of seasonal low flows are critical for a number of water management tasks that require inferences about water quality and the ecological status of water bodies. This paper proposes an extreme gradient tree boosting model (XGBoost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7208df7f89115a312be2e037b954b0b
https://doi.org/10.5194/hess-2022-141

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Unexpected Complexity of the Ammonia Monooxygenase in Archaea

Autor: Logan H. Hodgskiss, Michael Melcher, Melina Kerou, Weiqiang Chen, Rafael I. Ponce-Toledo, Savvas N. Savvides, Stefanie Wienkoop, Markus Hartl, Christa Schleper

Publikováno v: ISME JOURNAL

Ammonia oxidation as the first step of nitrification constitutes a critical process in the global nitrogen cycle. However, fundamental knowledge of its key enzyme, the copper-dependent ammonia monooxygenase is lacking, in particular for the environme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1080f4351dc3969e5474b89bfb2db14
https://doi.org/10.1101/2022.04.06.487334

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