Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Michael, Meisterernst"'
Autor:
Monika Graf, Marta Interlandi, Natalia Moreno, Dörthe Holdhof, Carolin Göbel, Viktoria Melcher, Julius Mertins, Thomas K. Albert, Dennis Kastrati, Amelie Alfert, Till Holsten, Flavia de Faria, Michael Meisterernst, Claudia Rossig, Monika Warmuth-Metz, Johannes Nowak, Gerd Meyer zu Hörste, Chloe Mayère, Serge Nef, Pascal Johann, Michael C. Frühwald, Martin Dugas, Ulrich Schüller, Kornelius Kerl
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Rhabdoid tumors (RT) are aggressive paediatric cancers with yet unknown cells of origin. Here, the authors establish genetically engineered mouse models of RT and, using single-cell RNA-seq and epigenomics, identify potential cells of origin for the
Externí odkaz:
https://doaj.org/article/124e1a551f524ef8bfe6f35ccde842d8
Autor:
Stephanie Beel, Lina Kolloch, Lisa H. Apken, Lara Jürgens, Andrea Bolle, Nadine Sudhof, Sankar Ghosh, Eva Wardelmann, Michael Meisterernst, Konrad Steinestel, Andrea Oeckinghaus
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The molecular mechanisms of acinar-to-ductal metaplasia (ADM) in the course of pancreatitis and cancer development are unclear. Here, the authors show that loss of κB-Ras and consequent Ral activation promotes tumour initiation and progression throu
Externí odkaz:
https://doaj.org/article/e878ae5e8abb4a2ba7984f050a3bbfcc
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146648 (2016)
CDK9 is the catalytic subunit of positive elongation factor b (P-TEFb) that controls the transition of RNA polymerase II (RNAPII) into elongation. CDK9 inhibitors block mRNA synthesis and trigger activation of the stress-sensitive p53 protein. This i
Externí odkaz:
https://doaj.org/article/0d63fe3fe2954f868b0fc382467caa25
Conformational changes and catalytic inefficiency associated with Mot1-mediated TBP–DNA dissociation
Autor:
David T. Auble, Ramya Viswanathan, Michael Meisterernst, Samson Glaser, Sushi Madhira, Lena Voith von Voithenberg, Peter Schluesche, Gregor Heiss, Don C. Lamb, Evelyn Ploetz
Publikováno v:
Nucleic Acids Research
The TATA-box Binding Protein (TBP) plays a central role in regulating gene expression and is the first step in the process of pre-initiation complex (PIC) formation on promoter DNA. The lifetime of TBP at the promoter site is controlled by several co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299da2492fca0057da360e64f06a53a6
https://doi.org/10.1093/nar/gky1322
https://doi.org/10.1093/nar/gky1322
Autor:
Monika Graf, Marta Interlandi, Natalia Moreno, Rajanya Roy, Dörthe Holdhof, Carolin Göbel, Viktoria Melcher, Julius Mertins, Thomas K Albert, Dennis Kastrati, Amelie Alfert, Till Holsten, Flavia de Faria, Michael Meisterernst, Claudia Rossig, Monika Warmuth-Metz, Johannes Nowak, Gerd Meyer zu Hörste, Chloe Mayère, Serge Nef, Pascal Johann, Michael C Frühwald, Martin Dugas, Ulrich Schüller, Kornelius Kerl
Publikováno v:
Neuro-Oncology. 24:i6-i6
Rhabdoid tumors (RT) are embryonal neoplasms occurring most frequently in the central nervous system where they are termed atypical teratoid rhabdoid tumor (ATRT). A common hallmark of RT is homozygous loss of the BAF complex subunit SMARCB1. RT pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21caa59de4e2b54d35d619dd5ffe1f1f
https://doi.org/10.1093/neuonc/noac079.014
https://doi.org/10.1093/neuonc/noac079.014
Autor:
Lisa H. Apken, Andrea Bolle, Lara Jürgens, Stephanie Beel, Konrad Steinestel, Lina Kolloch, Nadine Sudhof, Michael Meisterernst, Sankar Ghosh, Andrea Oeckinghaus, Eva Wardelmann
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Pancreatic ductal adenocarcinoma (PDAC) is associated with high mortality and therapy resistance. Here, we show that low expression of κB-Ras GTPases is frequently detected in PDAC and correlates with higher histologic grade. In a model of KRasG12D-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87c16063203f89f82bc09bb1d35b205
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 812, p 812 (2022)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 2; Pages: 812
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 2; Pages: 812
Inhibition of the dual function cell cycle and transcription kinase CDK7 is known to affect the viability of cancer cells, but the mechanisms underlying cell line-specific growth control remain poorly understood. Here, we employed a previously develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbed66db7279ec2bc9baada512416b30
https://doi.org/10.3390/ijms23020812
https://doi.org/10.3390/ijms23020812
Autor:
André Reis, Martin Berghoff, Bernal Morera, Sixto Bogantes-Ledezma, Arif B. Ekici, Alejandro Leal, Corinna Berghoff, Michael Meisterernst, Steffen Uebe, Heinrich Sticht, Christian Thiel
Publikováno v:
Neurogenetics
Charcot-Marie-Tooth disease (CMT) represents a heterogeneous group of hereditary peripheral neuropathies. We previously reported a CMT locus on chromosome 19q13.3 segregating with the disease in a large Costa Rican family with axonal neuropathy and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d3c87a0475c6fe85905d17c21144a0
https://doi.org/10.1007/s10048-018-0555-7
https://doi.org/10.1007/s10048-018-0555-7
Autor:
Pascal Johann, Kornelius Kerl, Natalia Moreno, Julius Mertins, Till Holsten, Michael Meisterernst, Annabelle Zhogbi, Marcel Kool
Publikováno v:
Oncotarget
Rhabdoid tumors are caused by the deletion of SMARCB1, whose protein encodes the SMARCB1 subunit of the chromatin remodeling complex SWI/SNF that is involved in global chromatin organization and gene expression control. Simultaneously inhibiting the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ba7b72745c54afff15132ed1a9276a
https://doi.org/10.18632/oncotarget.18583
https://doi.org/10.18632/oncotarget.18583
Publikováno v:
Biophysical journal. 115(12)
Single-pair Forster resonance energy transfer (spFRET) has become an important tool for investigating conformational dynamics in biological systems. To extract dynamic information from the spFRET traces measured with total internal reflection fluores
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6599c200af3403de93d330304607c5a
https://pubmed.ncbi.nlm.nih.gov/30527334
https://pubmed.ncbi.nlm.nih.gov/30527334