A randomised, double-blind, placebo-controlled trial of repeated nebulisation of non-viral cystic fibrosis transmembrane conductance regulator (CFTR) gene therapy in patients with cystic fibrosis

Autor: Eric WFW Alton, David K Armstrong, Deborah Ashby, Katie J Bayfield, Diana Bilton, Emily V Bloomfield, A Christopher Boyd, June Brand, Ruaridh Buchan, Roberto Calcedo, Paula Carvelli, Mario Chan, Seng H Cheng, David S Collie, Steve Cunningham, Heather E Davidson, Gwyneth Davies, Jane C Davies, Lee A Davies, Maria H Dewar, Ann Doherty, Jackie Donovan, Natalie S Dwyer, Hala I Elgmati, Rosanna F Featherstone, Jemyr Gavino, Sabrina Gea-Sorli, Duncan M Geddes, James SR Gibson, Deborah R Gill, Andrew P Greening, Uta Griesenbach, David M Hansell, Katharine Harman, Tracy E Higgins, Samantha L Hodges, Stephen C Hyde, Laura Hyndman, J Alastair Innes, Joseph Jacob, Nancy Jones, Brian F Keogh, Maria P Limberis, Paul Lloyd-Evans, Alan W Maclean, Michelle C Manvell, Dominique McCormick, Michael McGovern, Gerry McLachlan, Cuixiang Meng, M Angeles Montero, Hazel Milligan, Laura J Moyce, Gordon D Murray, Andrew G Nicholson, Tina Osadolor, Javier Parra-Leiton, David J Porteous, Ian A Pringle, Emma K Punch, Kamila M Pytel, Alexandra L Quittner, Gina Rivellini, Clare J Saunders, Ronald K Scheule, Sarah Sheard, Nicholas J Simmonds, Keith Smith, Stephen N Smith, Najwa Soussi, Samia Soussi, Emma J Spearing, Barbara J Stevenson, Stephanie G Sumner-Jones, Minna Turkkila, Rosa P Ureta, Michael D Waller, Marguerite Y Wasowicz, James M Wilson, Paul Wolstenholme-Hogg, on behalf of the UK Cystic Fibrosis Gene Therapy Consortium

Publikováno v: Efficacy and Mechanism Evaluation, Vol 3, Iss 5 (2016)

Background: Cystic fibrosis (CF) is a chronic, life-limiting disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene leading to abnormal airway surface ion transport, chronic lung infections, inflammation and eventual re

Externí odkaz: https://doaj.org/article/09b29fe1b155492fba24a177fe4be24c

Communicating Personal Melanoma Polygenic Risk Information: Participants’ Experiences of Genetic Counseling in a Community-Based Study

Autor: Amelia K, Smit, David, Espinoza, Georgina L, Fenton, Judy, Kirk, Jessica S, Innes, Michael, McGovern, Sharne, Limb, On Behalf Of The Managing Your Risk Study Group, Erin, Turbitt, Anne E, Cust

Publikováno v: Journal of Personalized Medicine; Volume 12; Issue 10; Pages: 1581

Personalized polygenic risk information may be used to guide risk-based melanoma prevention and early detection at a population scale, but research on communicating this information is limited. This mixed-methods study aimed to assess the acceptabili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b552f02976142a52837d441b8a4db0
https://doi.org/10.3390/jpm12101581

Influence of charge sequence on the adsorption of polyelectrolytes to oppositely-charged polyelectrolyte brushes

Autor: David C. Morse, Michael McGovern, Vaidyanathan Sethuraman, Kevin D. Dorfman

Publikováno v: Soft Matter. 15:5431-5442

When a solution of polyanionic chains is placed in contact with a polycationic brush, the polyanions adsorb into the brush. We investigate the influence of the charge sequences of the free and bound species on the thermodynamics of polyelectrolyte ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa141bc9b07a702b66e7b5f329977582
https://doi.org/10.1039/c9sm00581a

Durkheim and Heidegger: two social ontologies and some implications [in special issue celebrating the centenary of L'anne sociologique]

Autor: Michael McGovern

Publikováno v: Journal of the Anthropological Society of Oxford, Vol 29, Iss 2, Pp 105-120 (1998)

Externí odkaz: https://doaj.org/article/ceb04122294849b4a11db1e48d0df5ce

Particle-directed assembly of semiflexible polymer chains

Autor: David C. Morse, Michael McGovern, Kevin D. Dorfman

Publikováno v: Soft Matter. 12:6214-6222

We use Langevin dynamics simulations to study aggregation of semiflexible polymers driven by attractions between polymers and spherical particles. We consider a simple model with purely repulsive polymer/polymer and particle/particle interactions but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d93173022fcb02ccacc95f1b2bcbd30
https://doi.org/10.1039/c6sm00785f