Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Michael, Lohoff"'
Autor:
Jochen T. Frueh, Julia Campe, Daniele Yumi Sunaga-Franze, Nikita A. Verheyden, Sakhila Ghimire, Elisabeth Meedt, Denise Haslinger, Sabine Harenkamp, Daniel Staudenraus, Sascha Sauer, Andreas Kreft, Ralf Schubert, Michael Lohoff, Andreas Krueger, Halvard Bonig, Andreas G. Chiocchetti, Robert Zeiser, Ernst Holler, Evelyn Ullrich
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
ABSTRACTInterferon regulatory factor 4 (IRF4) is a master transcription factor that regulates T helper cell (Th) differentiation. It interacts with the Basic leucine zipper transcription factor, ATF-like (BATF), depletion of which in CD4+ T cells abr
Externí odkaz:
https://doaj.org/article/0e061017555b4bc0b1aa91d36567a9dd
Autor:
Julius C. Enssle, Julia Campe, Alina Moter, Isabel Voit, Alec Gessner, Ika Weija Yu, Sebastian Wolf, Björn Steffen, Thomas Oellerich, Hubert Serve, Melanie Bremm, Sabine Huenecke, Michael Lohoff, Maria Vehreschild, Holger F Rabenau, Marek Widera, Sandra Ciesek, Michael A Rieger, Katharina Imkeller, Ivana von Metzler, Evelyn Ullrich
Publikováno v:
HemaSphere, Vol 7, p e11813df (2023)
Externí odkaz:
https://doaj.org/article/6eeb2754933a41cda4d00f46d489e306
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/3d07185d50e14a4e89015549ab59957f
Autor:
Christina Lückel, Felix Picard, Hartmann Raifer, Lucia Campos Carrascosa, Anna Guralnik, Yajuan Zhang, Matthias Klein, Stefan Bittner, Falk Steffen, Sonja Moos, Federico Marini, Renee Gloury, Florian C. Kurschus, Ying-Yin Chao, Wilhelm Bertrams, Veronika Sexl, Bernd Schmeck, Lynn Bonetti, Melanie Grusdat, Michael Lohoff, Christina E. Zielinski, Frauke Zipp, Axel Kallies, Dirk Brenner, Michael Berger, Tobias Bopp, Björn Tackenberg, Magdalena Huber
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Dimethyl fumarate (DMF) is a therapy for multiple sclerosis (MS) with undetermined mechanism of action. Here the authors find that clinical response to DMF associates with decrease in IL-17-producing CD8+ T cells (Tc17), delineate molecular pathways
Externí odkaz:
https://doaj.org/article/2e2f0c2356834c5db881aabfe09b997c
Publikováno v:
European Journal of Immunology. 52:1680-1683
IRF4 knock-out cells do not differentiate properly into T helper subsets 2, 9, and 17. Compared to WT IRF4 point mutation L116R shows differentially expressed key cytokines. While amounts Th2 and Th17 cells are decreased, there is a strong induction
Autor:
Eliana Ribechini, James A. Hutchinson, Sabine Hergovits, Marion Heuer, Jörg Lucas, Ulrike Schleicher, Ana-Laura Jordán Garrote, Sarah J. Potter, Paloma Riquelme, Heike Brackmann, Nora Müller, Hartmann Raifer, Ingolf Berberich, Magdalena Huber, Andreas Beilhack, Michael Lohoff, Christian Bogdan, Matthias Eyrich, Heike M. Hermanns, Edward K. Geissler, Manfred B. Lutz
Publikováno v:
Blood Advances, Vol 1, Iss 14, Pp 947-960 (2017)
Abstract: Granulocyte-macrophage colony-stimulating factor (GM-CSF) controls proliferation and survival of myeloid cells including monocytes. Here, we describe a time-dependent licensing process driven by GM-CSF in murine Ly6Chigh and human CD14+ mon
Externí odkaz:
https://doaj.org/article/01939da1159e4606bd40390d8e10d0d3
Autor:
Lucia Campos Carrascosa, Matthias Klein, Yohko Kitagawa, Christina Lückel, Federico Marini, Anika König, Anna Guralnik, Hartmann Raifer, Stefanie Hagner-Benes, Diana Rädler, Andreas Böck, Cholho Kang, Michael Lohoff, Holger Garn, Bianca Schaub, Friederike Berberich-Siebelt, Shimon Sakaguchi, Tobias Bopp, Magdalena Huber
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
IFN-γ signalling inhibits production of IL-9, the defining cytokine of the Th9 cell subset. Here the authors show that IFN-γ does this by driving IRF1 to compete with IRF4 forIl9promoter binding and skewing these cells towards a Th1 phenotype, an e
Externí odkaz:
https://doaj.org/article/13172fb84a7445059a0849047683d7fa
Autor:
Markus Bardua, Claudia Haftmann, Pawel Durek, Kerstin Westendorf, Antje Buttgereit, Cam Loan Tran, Mairi McGrath, Melanie Weber, Katrin Lehmann, Richard Kwasi Addo, Gitta Anne Heinz, Anna-Barbara Stittrich, Patrick Maschmeyer, Helena Radbruch, Michael Lohoff, Hyun-Dong Chang, Andreas Radbruch, Mir-Farzin Mashreghi
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Proinflammatory type 1 T helper (Th1) cells are enriched in inflamed tissues and contribute to the maintenance of chronic inflammation in rheumatic diseases. Here we show that the microRNA- (miR-) 31 is upregulated in murine Th1 cells with a history
Externí odkaz:
https://doaj.org/article/3a3f2b7eb4ae4c198d432b833a7419c0
Autor:
Dennis Das Gupta, Michael Lohoff
Publikováno v:
European Journal of Immunology. 53
Autor:
Verena Nilius, Madeleine C. Killer, Nina Timmesfeld, Melina Schmitt, Roland Moll, Anja Lorch, Jörg Beyer, Elisabeth Mack, Michael Lohoff, Andreas Burchert, Andreas Neubauer, Cornelia Brendel
Publikováno v:
OncoImmunology, Vol 7, Iss 5 (2018)
Survival of patients with germ-cell cancer (GCC) and primary progression or relapse after cisplatin-based first-line chemotherapy is highly heterogeneous, ranging from close to zero to more than 70%. We investigated β-1,4-Galactosyltransferase-I (B4
Externí odkaz:
https://doaj.org/article/b2074d733f4e4969b76dca9ac4466552