Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation

Autor: Megan M Sperry, Berenice Charrez, Haleh Fotowat, Erica Gardner, Kanoelani Pilobello, Zohreh Izadifar, Tiffany Lin, Abigail Kuelker, Sahith Kaki, Michael Lewandowski, Shanda Lightbown, Ramses Martinez, Susan Marquez, Joel Moore, Maria Plaza-Oliver, Adama M Sesay, Kostyantyn Shcherbina, Katherine Sheehan, Takako Takeda, Daniela Del Campo, Kristina Andrijauskaite, Exal Cisneros, Riley Lopez, Isabella Cano, Zachary Maxwell, Israel Jessop, Rafa Veraza, Leon Bunegin, Thomas J Percival, Jaclyn Yracheta, Jorge J Pena, Diandra M Wood, Zachary T Homas, Cody J Hinshaw, Jennifer Cox-Hinshaw, Olivia G Parry, Justin J Sleeter, Erik K Weitzel, Michael Levin, Michael Super, Richard Novak, Donald E Ingber

Publikováno v: eLife, Vol 13 (2024)

Drugs that induce reversible slowing of metabolic and physiological processes would have great value for organ preservation, especially for organs with high susceptibility to hypoxia-reperfusion injury, such as the heart. Using whole-organism screeni

Externí odkaz: https://doaj.org/article/095738c148254bf3aca1f94a4c99d2bb

Identification of a pharmaceutical biostasis inducer that slows metabolism in multiple vertebrates that do not hibernate

Autor: Megan M. Sperry, Berenice Charrez, Haleh Fotowat, Erica Gardner, Kanoelani Pilobello, Zohreh Izadifar, Tiffany Lin, Abigail Kuelker, Sahith Kaki, Michael Lewandowski, Shanda Lightbown, Ramses Martinez, Susan Marquez, Adama M. Sesay, Kostyantyn Shcherbina, Takako Takeda, Kristina Andrijauskaite, Exal Cisneros, Riley Lopez, Isabella Cano, Zachary Maxwell, Rafael J. Veraza, Leon Bunegin, Thomas J. Percival, Jaclyn Yracheta, Jorge Pena, Diandra Wood, Zachary Homas, Cody Hinshaw, Jen Cox-Hinshaw, Olivia G. Parry, Justin J. Sleeter, Erik K. Weitzel, Michael Levin, Michael Super, Richard Novak, Donald E. Ingber

An injectable ‘biostasis’ drug that could slow organ injury by inducing a state of suspended animation through reversible slowing of metabolic processes would have great value for organ preservation and treatment of badly injured patients at the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b728a004cc89bd3e08e2e0b83b071caa
https://doi.org/10.1101/2023.02.27.530270

Cytotoxicity and oxidative stress induced by atmospheric mono-nitrophenols in human lung cells

Autor: Faria Khan, Mohammed Jaoui, Krzysztof Rudziński, Karina Kwapiszewska, Alicia Martinez-Romero, Domingo Gil-Casanova, Michael Lewandowski, Tadeusz E. Kleindienst, John H. Offenberg, Jonathan D. Krug, Jason D. Surratt, Rafal Szmigielski

Publikováno v: ENVIRONMENTAL POLLUTION
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname
Environmental Pollution

Nitrophenols (NPs) are hazardous pollutants found in various environmental matrices, including ambient fine particulate matter (PM2.5), agricultural residues, rainwater, wildfires, and industrial wastes. This study showed for the first time the effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4749f526c25e9c762b4629553c391732
https://pubmed.ncbi.nlm.nih.gov/35217136

Time Resolved PIV Measurements of a Slot Lobed Jet Issuing Into a Crossflow

Autor: Abdullah G. Weiss, Paul J. Kristo, Mark Kimber, Michael Lewandowski

Publikováno v: Volume 2: Fluid Applications and Systems; Fluid Measurement and Instrumentation.

The near field mixing phenomenon created by a round jet with three slot lobes exhausting into a crossflow are investigated at a velocity ratio of 0.5. Time-resolved particle image velocimetry measurements provide instantaneous velocity fields of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::103b95d4deac0386fbcc7882d6be1ae7
https://doi.org/10.1115/fedsm2021-65783

Relative contributions of selected multigeneration products to chamber SOA formed from photooxidation of a range (C

Autor: Kenneth S, Docherty, Robert, Yaga, William, Preston, Mohammed, Jaoui, Theran P, Reidel, John H, Offenberg, Tadeusz E, Kleindienst, Michael, Lewandowski

Publikováno v: Atmos Environ (1994)

A series of chamber experiments was conducted to investigate the composition of secondary organic aerosol (SOA) following oxidation of a range of parent n-alkanes (C(10)–C(17)) in the presence of NO(x). The relative contribution of selected species

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::74968d8e4271b568c6402379ca3be753
https://pubmed.ncbi.nlm.nih.gov/33364911