Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Michael, Letavic"'
Autor:
Yi Liu, Jichun Ma, Renee L. DesJarlais, Rebecca Hagan, Jason Rech, Changlu Liu, Robyn Miller, Jeffrey Schoellerman, Jinquan Luo, Michael Letavic, Bruce Grasberger, Michael P. Maher
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract Acid-sensing ion channels (ASICs) are proton-gated cation channels widely expressed in the nervous system. ASIC gating is modulated by divalent cations as well as small molecules; however, the molecular determinants of gating modulation by d
Externí odkaz:
https://doaj.org/article/7532453b22314d01ada9b275f434a0b8
Autor:
Yi Liu, Jichun Ma, Renee L. DesJarlais, Rebecca Hagan, Jason Rech, David Lin, Changlu Liu, Robyn Miller, Jeffrey Schoellerman, Jinquan Luo, Michael Letavic, Bruce Grasberger, Michael Maher
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Liu et al study the molecular and structural mechanism of the modulation of ASIC1 channel gating using functional, crystallographic, computational and mutational approaches. They identify small molecules that allosterically stabilize the closed state
Externí odkaz:
https://doaj.org/article/cd6928ca293c4d9a8cd20517994d727a
Autor:
Tamara, Berdyyeva, Chunfang, Xia, Natalie, Taylor, Yingbo, He, Gang, Chen, Chaofeng, Huang, Wei, Zhang, Hartmuth, Kolb, Michael, Letavic, Anindya, Bhattacharya, Anna Katrin, Szardenings
Publikováno v:
Molecular imaging and biology. 21(5)
The P2X7 receptor, an adenosine triphosphate (ATP)-gated purinoreceptor, has emerged as one of the key players in neuroinflammatory processes. Therefore, developing a positron emission tomography (PET) tracer for imaging of P2X7 receptors in vivo pre
Autor:
Hartmuth C, Kolb, Olivier, Barret, Anindya, Bhattacharya, Gang, Chen, Cristian, Constantinescu, Chaofeng, Huang, Michael, Letavic, Gilles, Tamagnan, Chunfang A, Xia, Wei, Zhang, Anna Katrin, Szardenings
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 60(8)
The P2X7 receptor is an adenosine triphosphate-gated ion channel, which is abundantly expressed in glial cells within the central nervous system and in the periphery. P2X7 receptor activation leads to the release of the proinflammatory cytokine IL-1