Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Michael, Lardelli"'
Autor:
Lachlan Baer, Karissa Barthelson, John H Postlethwait, David L Adelson, Stephen M Pederson, Michael Lardelli
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 2, p e1011868 (2024)
In comparisons between mutant and wild-type genotypes, transcriptome analysis can reveal the direct impacts of a mutation, together with the homeostatic responses of the biological system. Recent studies have highlighted that, when the effects of hom
Externí odkaz:
https://doaj.org/article/d9c21ff053ad40258f64fe602bea9ede
Publikováno v:
BMC Research Notes, Vol 14, Iss 1, Pp 1-5 (2021)
Abstract Objective NGFR/p75NTR and NRADD/NRH proteins are closely related structurally and are encoded by genes that arose from a duplication event early in vertebrate evolution. The transmembrane domain (TMD) of NGFR is cleaved by γ-secretase but t
Externí odkaz:
https://doaj.org/article/ac89740387da41a380f6ce0fb9f9d4a3
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-4 (2021)
Abstract Mutation of the gene PARK7 (DJ1) causes monogenic autosomal recessive Parkinson’s disease (PD) in humans. Subsequent alterations of PARK7 protein function lead to mitochondrial dysfunction, a major element in PD pathology. Homozygous mutan
Externí odkaz:
https://doaj.org/article/6583a5d4deeb42c49478054092cc4fb9
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-16 (2021)
Abstract Background Early-onset familial Alzheimer’s disease (EOfAD) is promoted by dominant mutations, enabling the study of Alzheimer’s disease (AD) pathogenic mechanisms through generation of EOfAD-like mutations in animal models. In a previou
Externí odkaz:
https://doaj.org/article/3cb1ca6fc7c347f492c27106f7e2b689
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-4 (2021)
Abstract Previously, we found that brains of adult zebrafish heterozygous for Alzheimer’s disease-related mutations in their presenilin 1 gene (psen1, orthologous to human PSEN1) show greater basal expression levels of hypoxia responsive genes rela
Externí odkaz:
https://doaj.org/article/cdf84d6aba8e4b4d98a830c995ee9d41
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-19 (2020)
Abstract To prevent or delay the onset of Alzheimer’s disease (AD), we must understand its molecular basis. The great majority of AD cases arise sporadically with a late onset after 65 years of age (LOAD). However, rare familial cases of AD can occ
Externí odkaz:
https://doaj.org/article/a77336e36364429eb02a9ed52eaa0bd5
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 1 (2022)
Energy production is the most fundamentally important cellular activity supporting all other functions, particularly in highly active organs, such as brains. Here, we summarise transcriptome analyses of young adult (pre-disease) brains from a collect
Externí odkaz:
https://doaj.org/article/bac501b1fba34123846a1bef44705602
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-5 (2019)
Abstract To prevent or ameliorate Alzheimer’s disease (AD) we must understand its molecular basis. AD develops over decades but detailed molecular analysis of AD brains is limited to postmortem tissue where the stresses initiating the disease may b
Externí odkaz:
https://doaj.org/article/3ea0bac87e084e2d9453048cd33b2155
Autor:
Karissa Barthelson, Lachlan Baer, Yang Dong, Melanie Hand, Zac Pujic, Morgan Newman, Geoffrey J. Goodhill, Robert I. Richards, Stephen M. Pederson, Michael Lardelli
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Zebrafish represent a valuable model for investigating the molecular and cellular basis of Fragile X syndrome (FXS). Reduced expression of the zebrafish FMR1 orthologous gene, fmr1, causes developmental and behavioural phenotypes related to FXS. Zebr
Externí odkaz:
https://doaj.org/article/8c74c3c0e3554ed1a8851000275ae0a5
Autor:
Nhi Hin, Morgan Newman, Jan Kaslin, Alon M Douek, Amanda Lumsden, Seyed Hani Moussavi Nik, Yang Dong, Xin-Fu Zhou, Noralyn B Mañucat-Tan, Alastair Ludington, David L Adelson, Stephen Pederson, Michael Lardelli
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227258 (2020)
BACKGROUND:The molecular changes involved in Alzheimer's disease (AD) progression remain unclear since we cannot easily access antemortem human brains. Some non-mammalian vertebrates such as the zebrafish preserve AD-relevant transcript isoforms of t
Externí odkaz:
https://doaj.org/article/03c0068989154a2db2a04048633ea4c2