Výsledky vyhledávání - "Michael, Korth"

Nucleoside Diphosphate Kinase B–Activated Intermediate Conductance Potassium Channels Are Critical for Neointima Formation in Mouse Carotid Arteries

Autor: Edward Y. Skolnik, Qiang Sun, Yi Qiu, Thomas Wieland, Robert Lukowski, Martin Borggrefe, Yu-Xi Feng, Dobromir Dobrev, Xiaobo Zhou, Michael Korth, Peter Ruth, Katharina Spiger, Zhai Li

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 35:1852-1861

Objective— Vascular smooth muscle cells (VSMC) proliferation is a hallmark of atherosclerosis and vascular restenosis. The intermediate conductance Ca 2+ -activated K + (SK4) channel is required for pathological VSMC proliferation. In T lymphocytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a09b4163c3fae1b8ddee87dacaa85f
https://doi.org/10.1161/atvbaha.115.305881

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Dual role of protein kinase C on BK channel regulation

Autor: Emine Utku, Peter Ruth, Michael Korth, Ulrike Sausbier, Xiaobo Zhou, Iris Wulfsen, Thomas Wieland, Matthias Sausbier

Publikováno v: Proceedings of the National Academy of Sciences. 107:8005-8010

Large conductance voltage- and Ca 2+ -activated potassium channels (BK channels) are important feedback regulators in excitable cells and are potently regulated by protein kinases. The present study reveals a dual role of protein kinase C (PKC) on BK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a66c71ebc483614dfbbab0add61da4e1
https://doi.org/10.1073/pnas.0912029107

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Inducible knockout mutagenesis reveals compensatory mechanisms elicited by constitutive BK channel deficiency in overactive murine bladder

Autor: Tobias Lamkemeyer, Andreas Jakob, Winfried Neuhuber, Angela Wirth, Johannes Madlung, Patrick Pankert, Alfred Nordheim, Franz Sprossmann, Michael J. Shipston, Ulrike Sausbier, Stefan Offermanns, Iancu Bucurenciu, Xiaobo Zhou, Michael Korth, Matthias Sausbier, Peter Ruth, Hong Zhao

Publikováno v: FEBS Journal. 276:1680-1697

The large-conductance, voltage-dependent and Ca(2+)-dependent K(+) (BK) channel links membrane depolarization and local increases in cytosolic free Ca(2+) to hyperpolarizing K(+) outward currents, thereby controlling smooth muscle contractility. Cons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8924b47fc7d373c5db0b65f27844d145
https://doi.org/10.1111/j.1742-4658.2009.06900.x

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Reduced rather than enhanced cholinergic airway constriction in mice with ablation of the large conductance Ca2+‐activated K+channel

Autor: Stefan Uhlig, Daniela Wolpers, Thomas Gudermann, Peter Ruth, Franz Hofmann, Xiaobo Zhou, Winfried Neuhuber, Harald Renz, Anna-Rebekka Ressmeyer, Ulrike Sausbier, Christian Martin, Michael Korth, Jens Schlossmann, Matthias Sausbier, Caroline Beier, Sylvi Maget, Alexander Dietrich

Publikováno v: The FASEB Journal. 21:812-822

The unique voltage- and Ca2+-dependent K+ (BK) channel, prominently expressed in airway smooth muscle cells, has been suggested as an important effector in controlling airway contractility. Its deletion in mice depolarized resting membrane potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a17f2f6bec7dc851f26ad065dfc88d4c
https://doi.org/10.1096/fj.06-7167com

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Effects of doxorubicinol on excitation–contraction coupling in guinea pig ventricular myocytes

Autor: Ge-Xin Wang, Yong-Xiao Wang, Xiaobo Zhou, Michael Korth

Publikováno v: European Journal of Pharmacology. 423:99-107

The cardiotoxicity of the anticancer drug doxorubicin may be related to its main metabolite doxorubicinol. In this study, the acute effects of doxorubicinol on excitation–contraction coupling in isolated guinea pig ventricular myocytes were investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2741c953dc2e167556d24eef6ccb44a
https://doi.org/10.1016/s0014-2999(01)01096-2

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BKCachannel activation by membrane-associated cGMP kinase may contribute to uterine quiescence in pregnancy

Autor: Michael Korth, Xiaobo Zhou, Ge-Xin Wang, Bernd Hüneke, Peter Ruth

Publikováno v: American Journal of Physiology-Cell Physiology. 279:C1751-C1759

We investigated the influence of pregnancy on large-conductance calcium-activated potassium channel (BKCa) activity ( NPo) and on channel expression in membranes of isolated human myometrial smooth muscle cells. NPoin inside-out patches was higher in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e27181abfdb7906332479854506b6f
https://doi.org/10.1152/ajpcell.2000.279.6.c1751

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Effects of mitoxantrone on action potential and membrane currents in isolated cardiac myocytes

Autor: Michael Korth, Ge-Xin Wang, Thomas Eschenhagen, Xiaobo Zhou

Publikováno v: British Journal of Pharmacology. 127:321-330

1. The effects of mitoxantrone (MTO), an anticancer drug, on the membrane electrical properties of cardiac myocytes were investigated using the whole-cell clamp technique. 2. In isolated guinea-pig ventricular myocytes, 30 microM MTO induced a time-d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5758c9345f233b527ee09def44600be8
https://doi.org/10.1038/sj.bjp.0702547

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Differential Effect of ?-Adrenergic Stimulation on the Frequency-Dependent Electrophysiologic Actions of the New Class III Antiarrhythmics Dofetilide, Ambasilide, and Chromanol 293

Autor: Jürgen Schreieck, Bernhard Zrenner, Michael Korth, Claus Schmitt, Albert Schömig, Viktor Gjini, Yanggan Wang

Publikováno v: Journal of Cardiovascular Electrophysiology. 8:1420-1430

Class III Antiarrhythmics and β-Adrenergic Stimulation. Introduction: Blockade of the rapid delayed rectifier potassium current (IKr) as an important mechanism for current Class III antiarrhythmics is less effective in action potential prolongation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9cca2cc597e6cd339fb2189753fdd14
https://doi.org/10.1111/j.1540-8167.1997.tb01039.x

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