Single-nucleus and Spatially Resolved Intratumor Subtype Heterogeneity in Bladder Cancer

Autor: Sia V. Lindskrog, Sofie S. Schmøkel, Iver Nordentoft, Philippe Lamy, Michael Knudsen, Frederik Prip, Trine Strandgaard, Jørgen Bjerggaard Jensen, Lars Dyrskjøt

Publikováno v: European Urology Open Science, Vol 51, Iss , Pp 78-88 (2023)

Background: Current bulk transcriptomic classification systems for bladder cancer do not consider the level of intratumor subtype heterogeneity. Objective: To investigate the extent and possible clinical impact of intratumor subtype heterogeneity acr

Externí odkaz: https://doaj.org/article/a4a32cfb28414004a84725a2cbf068dc

Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis

Autor: Ann Taber, Emil Christensen, Philippe Lamy, Iver Nordentoft, Frederik Prip, Sia Viborg Lindskrog, Karin Birkenkamp-Demtröder, Trine Line Hauge Okholm, Michael Knudsen, Jakob Skou Pedersen, Torben Steiniche, Mads Agerbæk, Jørgen Bjerggaard Jensen, Lars Dyrskjøt

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

There are currently only a few biomarkers to predict the response of muscle invasive bladder cancer to therapy. Here, the authors analyse 300 tumors using exome and RNA sequencing and find that tumors with a high degree of genomic instability and a n

Externí odkaz: https://doaj.org/article/3885a19d3a524eca9c7327f222740721

Cell-Free Urine and Plasma DNA Mutational Analysis Predicts Neoadjuvant Chemotherapy Response and Outcome in Patients with Muscle-Invasive Bladder Cancer

Autor: Emil Christensen, Iver Nordentoft, Karin Birkenkamp-Demtröder, Sara K. Elbæk, Sia V. Lindskrog, Ann Taber, Tine G. Andreasen, Trine Strandgaard, Michael Knudsen, Philippe Lamy, Mads Agerbæk, Jørgen B. Jensen, Lars Dyrskjøt

Publikováno v: Christensen, E, Nordentoft, I, Birkenkamp-Demtroder, K, Elbæk, S K, Lindskrog, S V, Taber, A, Andreasen, T G, Strandgaard, T, Knudsen, M, Lamy, P, Agerbæk, M, Jensen, J B & Dyrskjøt, L 2023, ' Cell-free urine-and plasma DNA mutational analysis predicts neoadjuvant chemotherapy response and outcome in patients with muscle invasive bladder cancer ', Clinical Cancer Research, vol. 29, no. 8, pp. 1582–1591 . https://doi.org/10.1158/1078-0432.CCR-22-3250

Purpose: To investigate the use of plasma and urine DNA mutation analysis for predicting neoadjuvant chemotherapy (NAC) response and oncological outcome in patients with muscle-invasive bladder cancer. Experimental Design: Whole-exome sequencing of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf1f58ca57cdc96542ccdf2f65dc41d
https://doi.org/10.1158/1078-0432.ccr-22-3250

Characterization of genetic intratumor heterogeneity in colorectal cancer and matching patient‐derived spheroid cultures

Autor: Sigrid S. Árnadóttir, Maria Jeppesen, Philippe Lamy, Jesper B. Bramsen, Iver Nordentoft, Michael Knudsen, Søren Vang, Mogens R. Madsen, Ole Thastrup, Jacob Thastrup, Claus L. Andersen

Publikováno v: Molecular Oncology, Vol 12, Iss 1, Pp 132-147 (2018)

Patient‐derived in vitro cultures of colorectal cancer (CRC) may help guide treatment strategies prior to patient treatment. However, most previous studies have been performed on a single biopsy per tumor. The purpose of this study was to analyze m

Externí odkaz: https://doaj.org/article/d25f2bdbf3e844efbdfafe4d3439846a

Supplementary Table S2 from Cell-Free Urine and Plasma DNA Mutational Analysis Predicts Neoadjuvant Chemotherapy Response and Outcome in Patients with Muscle-Invasive Bladder Cancer

Autor: Lars Dyrskjøt, Jørgen B. Jensen, Mads Agerbæk, Philippe Lamy, Michael Knudsen, Trine Strandgaard, Tine G. Andreasen, Ann Taber, Sia V. Lindskrog, Sara K. Elbæk, Karin Birkenkamp-Demtröder, Iver Nordentoft, Emil Christensen

Clinical data and follow-up data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5455250d6214eb3d469c6019dfbe49c5
https://doi.org/10.1158/1078-0432.22633004