Zobrazeno 1 - 10
of 216
pro vyhledávání: '"Michael, Kinter"'
Autor:
Kylene M. Harold, Satoshi Matsuzaki, Atul Pranay, Brooke L. Loveland, Albert Batushansky, Maria F. Mendez Garcia, Craig Eyster, Stavros Stavrakis, Ying Ann Chiao, Michael Kinter, Kenneth M. Humphries
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 7 (2024)
Background Phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase (PFK‐2) is a critical glycolytic regulator responsible for upregulation of glycolysis in response to insulin and adrenergic signaling. PFKFB2, the cardiac isoform of PFK‐2, is
Externí odkaz:
https://doaj.org/article/7b80fa90133942b79d878e1f4b38ac6e
Autor:
Jordan D. Fuqua, Marcus M. Lawrence, Zachary R. Hettinger, Agnieszka K. Borowik, Parker L. Brecheen, Marcelina M. Szczygiel, Claire B. Abbott, Frederick F. Peelor III, Amy L. Confides, Michael Kinter, Sue C. Bodine, Esther E. Dupont‐Versteegden, Benjamin F. Miller
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 5, Pp 2076-2089 (2023)
Abstract Background Skeletal muscle mass and strength diminish during periods of disuse but recover upon return to weight bearing in healthy adults but are incomplete in old muscle. Efforts to improve muscle recovery in older individuals commonly aim
Externí odkaz:
https://doaj.org/article/d851fd486f8f4e6f9a75250858a8e346
Autor:
Jarrod C. Harman, Aldina Pivodic, Anders K. Nilsson, Myriam Boeck, Hitomi Yagi, Katherine Neilsen, Minji Ko, Jay Yang, Michael Kinter, Ann Hellström, Zhongjie Fu
Publikováno v:
iScience, Vol 26, Iss 10, Pp 108021- (2023)
Summary: Nutritional deprivation occurring in most preterm infants postnatally can induce hyperglycemia, a significant and independent risk factor for suppressing physiological retinal vascularization (Phase I retinopathy of prematurity (ROP)), leadi
Externí odkaz:
https://doaj.org/article/9b62677d41a2468889dd14720be72d1f
Autor:
Agnieszka Czyżowska, Jacob Brown, Hongyang Xu, Kavitha Sataranatarajan, Michael Kinter, Victoria J. Tyrell, Valerie B. O'Donnell, Holly Van Remmen
Publikováno v:
Redox Biology, Vol 64, Iss , Pp 102761- (2023)
Our previous studies support a key role for mitochondrial lipid hydroperoxides as important contributors to denervation-related muscle atrophy, including muscle atrophy associated with aging. Phospholipid hydroperoxide glutathione peroxidase 4 (GPX4)
Externí odkaz:
https://doaj.org/article/5ff81d932c6e4952806e59208fb00ab3
Autor:
Yao Fu, Albert Batushansky, Michael Kinter, Janet L. Huebner, Virginia B. Kraus, Timothy M. Griffin
Publikováno v:
JBMR Plus, Vol 7, Iss 7, Pp n/a-n/a (2023)
ABSTRACT Leptin is a proinflammatory adipokine that contributes to obesity‐associated osteoarthritis (OA), especially in women. However, the extent to which leptin causes knee OA separate from the effect of increased body weight is not clear. We hy
Externí odkaz:
https://doaj.org/article/aa1cc937840a407a886dca46ed902848
Autor:
Maria F. Mendez Garcia, Satoshi Matsuzaki, Albert Batushansky, Ryan Newhardt, Caroline Kinter, Yan Jin, Shivani N. Mann, Michael B. Stout, Haiwei Gu, Ying Ann Chiao, Michael Kinter, Kenneth M. Humphries
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107131- (2023)
Summary: A healthy heart adapts to changes in nutrient availability and energy demands. In metabolic diseases like type 2 diabetes (T2D), increased reliance on fatty acids for energy production contributes to mitochondrial dysfunction and cardiomyopa
Externí odkaz:
https://doaj.org/article/ffdebaa794634e58a940833770287078
Autor:
Jacob L. Brown, Fredrick F. Peelor, III, Constantin Georgescu, Jonathan D. Wren, Michael Kinter, Victoria J. Tyrrell, Valerie B. O'Donnell, Benjamin F. Miller, Holly Van Remmen
Publikováno v:
Redox Biology, Vol 57, Iss , Pp 102518- (2022)
Loss of innervation is a key driver of age associated muscle atrophy and weakness (sarcopenia). Our laboratory has previously shown that denervation induced atrophy is associated with the generation of mitochondrial hydroperoxides and lipid mediators
Externí odkaz:
https://doaj.org/article/3239a27805754d5683dbbbba59aaf6a0
Autor:
Satoshi Matsuzaki, Craig Eyster, Maria F. Newhardt, Jennifer R. Giorgione, Caroline Kinter, Zachary T. Young, Michael Kinter, Kenneth M. Humphries
Publikováno v:
Redox Biology, Vol 47, Iss , Pp 102140- (2021)
Diabetic cardiomyopathy is associated with an increase in oxidative stress. However, antioxidant therapy has shown a limited capacity to mitigate disease pathology. The molecular mechanisms responsible for the modulation of reactive oxygen species (R
Externí odkaz:
https://doaj.org/article/2213bc327ff1448cbd122f6bbf80ee4e
Autor:
Bumsoo Ahn, Rojina Ranjit, Pavithra Premkumar, Gavin Pharaoh, Katarzyna M. Piekarz, Satoshi Matsuzaki, Dennis R. Claflin, Kaitlyn Riddle, Jennifer Judge, Shylesh Bhaskaran, Kavithalakshmi Satara Natarajan, Erika Barboza, Benjamin Wronowski, Michael Kinter, Kenneth M. Humphries, Timothy M. Griffin, Willard M. Freeman, Arlan Richardson, Susan V. Brooks, Holly Van Remmen
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 2, Pp 411-428 (2019)
Abstract Background Excess reactive oxygen species (ROS) and muscle weakness occur in parallel in multiple pathological conditions. However, the causative role of skeletal muscle mitochondrial ROS (mtROS) on neuromuscular junction (NMJ) morphology an
Externí odkaz:
https://doaj.org/article/bf068644f5f343948ea2be767d068283
Autor:
Ping Li, Maria F. Newhardt, Satoshi Matsuzaki, Craig Eyster, Atul Pranay, Frederick F. Peelor, Albert Batushansky, Caroline Kinter, Kumar Subramani, Sandeep Subrahmanian, Jasimuddin Ahamed, Pengchun Yu, Michael Kinter, Benjamin F. Miller, Kenneth M. Humphries
Publikováno v:
GeroScience. 45:983-999
SIRT3 is a longevity factor that acts as the primary deacetylase in mitochondria. Although ubiquitously expressed, previous global SIRT3 knockout studies have shown primarily a cardiac-specific phenotype. Here, we sought to determine how specifically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028d8a219d1235fa84aa9a88388f57cd
https://doi.org/10.1007/s11357-022-00695-0
https://doi.org/10.1007/s11357-022-00695-0