Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Michael, Kiffe"'
Autor:
Diana Graus Porta, William R. Sellers, Francesco Hofmann, Jutta Blank, Pascal Furet, Robert Mah, Catherine Leblanc, Nicole Buschmann, Thomas Knoepfel, Audrey Kauffmann, Masato Murakami, Patrizia Barzaghi-Rinaudo, Youzhen Wang, Armin Wolf, Philippe Couttet, Heiko S. Schadt, Jacqueline Kinyamu-Akunda, Markus Wartmann, Mario Centeleghe, Dario Sterker, Michael Kiffe, Robin A. Fairhurst, Christelle Stamm, Alexandra Buhles, Flavia Adler, Andreas Weiss
Activity of FGF401 in biochemical kinase assays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de614aa92fc53e000078388a9034229
https://doi.org/10.1158/1535-7163.22506502.v1
https://doi.org/10.1158/1535-7163.22506502.v1
Autor:
Diana Graus Porta, William R. Sellers, Francesco Hofmann, Jutta Blank, Pascal Furet, Robert Mah, Catherine Leblanc, Nicole Buschmann, Thomas Knoepfel, Audrey Kauffmann, Masato Murakami, Patrizia Barzaghi-Rinaudo, Youzhen Wang, Armin Wolf, Philippe Couttet, Heiko S. Schadt, Jacqueline Kinyamu-Akunda, Markus Wartmann, Mario Centeleghe, Dario Sterker, Michael Kiffe, Robin A. Fairhurst, Christelle Stamm, Alexandra Buhles, Flavia Adler, Andreas Weiss
Details on materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855b9cca12680f3ffc27bb3edd85e4d5
https://doi.org/10.1158/1535-7163.22506505.v1
https://doi.org/10.1158/1535-7163.22506505.v1
Autor:
Diana Graus Porta, William R. Sellers, Francesco Hofmann, Jutta Blank, Pascal Furet, Robert Mah, Catherine Leblanc, Nicole Buschmann, Thomas Knoepfel, Audrey Kauffmann, Masato Murakami, Patrizia Barzaghi-Rinaudo, Youzhen Wang, Armin Wolf, Philippe Couttet, Heiko S. Schadt, Jacqueline Kinyamu-Akunda, Markus Wartmann, Mario Centeleghe, Dario Sterker, Michael Kiffe, Robin A. Fairhurst, Christelle Stamm, Alexandra Buhles, Flavia Adler, Andreas Weiss
PK and PK/PD of FGF401 in mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a8adc6be4db10400fb7b3afdb43e38
https://doi.org/10.1158/1535-7163.22506514.v1
https://doi.org/10.1158/1535-7163.22506514.v1
Autor:
Diana Graus Porta, William R. Sellers, Francesco Hofmann, Jutta Blank, Pascal Furet, Robert Mah, Catherine Leblanc, Nicole Buschmann, Thomas Knoepfel, Audrey Kauffmann, Masato Murakami, Patrizia Barzaghi-Rinaudo, Youzhen Wang, Armin Wolf, Philippe Couttet, Heiko S. Schadt, Jacqueline Kinyamu-Akunda, Markus Wartmann, Mario Centeleghe, Dario Sterker, Michael Kiffe, Robin A. Fairhurst, Christelle Stamm, Alexandra Buhles, Flavia Adler, Andreas Weiss
This file provides the full characterization of FGF401
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3a6190c2b2732e54abfeea8a8dd793
https://doi.org/10.1158/1535-7163.22506520
https://doi.org/10.1158/1535-7163.22506520
Autor:
Diana Graus Porta, William R. Sellers, Francesco Hofmann, Jutta Blank, Pascal Furet, Robert Mah, Catherine Leblanc, Nicole Buschmann, Thomas Knoepfel, Audrey Kauffmann, Masato Murakami, Patrizia Barzaghi-Rinaudo, Youzhen Wang, Armin Wolf, Philippe Couttet, Heiko S. Schadt, Jacqueline Kinyamu-Akunda, Markus Wartmann, Mario Centeleghe, Dario Sterker, Michael Kiffe, Robin A. Fairhurst, Christelle Stamm, Alexandra Buhles, Flavia Adler, Andreas Weiss
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and it is the third leading cause of cancer-related deaths worldwide. Recently, aberrant signaling through the FGF19/FGFR4 axis has been implicated in HCC. Here, we des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13e8f6230bcc0ef53c3f3f3f81212e3c
https://doi.org/10.1158/1535-7163.c.6538417.v1
https://doi.org/10.1158/1535-7163.c.6538417.v1
Autor:
Robin A. Fairhurst, Pascal Furet, Patricia Imbach-Weese, Frédéric Stauffer, Heinrich Rueeger, Clive McCarthy, Sebastien Ripoche, Susanne Oswald, Bertrand Arnaud, Aline Jary, Michel Maira, Christian Schnell, Daniel A. Guthy, Markus Wartmann, Michael Kiffe, Sandrine Desrayaud, Francesca Blasco, Toni Widmer, Frank Seiler, Sascha Gutmann, Mark Knapp, Giorgio Caravatti
Publikováno v:
Journal of Medicinal Chemistry. 65:8345-8379
Balanced pan-class I phosphoinositide 3-kinase inhibition as an approach to cancer treatment offers the prospect of treating a broad range of tumor types and/or a way to achieve greater efficacy with a single inhibitor. Taking buparlisib as the start
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a308bfc3e4d7e6ca0655f9bedbe9796
https://doi.org/10.1021/acs.jmedchem.2c00267
https://doi.org/10.1021/acs.jmedchem.2c00267
Autor:
Anita Schlierf, Eva Altmann, Jean Quancard, Anne B. Jefferson, René Assenberg, Martin Renatus, Matthew Jones, Ulrich Hassiepen, Michael Schaefer, Michael Kiffe, Andreas Weiss, Christian Wiesmann, Richard Sedrani, Jörg Eder, Bruno Martoglio
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Dysregulation of protein degradation by the ubiquitin-proteasome system is a feature commonly associated with cancer. Here, the authors develop an orally available small molecule that inhibits CSN5, the proteolytic subunit of the COP9 signalosome, an
Externí odkaz:
https://doaj.org/article/6813730e8c8647398b624ca609051b9b
Autor:
Ying Huang, Martin Sendzik, Jeff Zhang, Zhenting Gao, Yongfeng Sun, Long Wang, Justin Gu, Kehao Zhao, Zhengtian Yu, Lijun Zhang, Qiong Zhang, Joachim Blanz, Zijun Chen, Valérie Dubost, Douglas Fang, Lijian Feng, Xingnian Fu, Michael Kiffe, Ling Li, Fangjun Luo, Xiao Luo, Yuan Mi, Prakash Mistry, David Pearson, Alessandro Piaia, Clemens Scheufler, Remi Terranova, Andreas Weiss, Jue Zeng, Hailong Zhang, Jiangwei Zhang, Mengxi Zhao, Michael P. Dillon, Sebastien Jeay, Wei Qi, Jonathan Moggs, Carole Pissot-Soldermann, En Li, Peter Atadja, Andreas Lingel, Counde Oyang
Publikováno v:
Journal of Medicinal Chemistry. 65:5317-5333
Polycomb Repressive Complex 2 (PRC2) plays an important role in transcriptional regulation during animal development and in cell differentiation, and alteration of PRC2 activity has been associated with cancer. On a molecular level, PRC2 catalyzes me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8a2d3773ad89ebc7852a400a3f915e
https://doi.org/10.1021/acs.jmedchem.1c02148
https://doi.org/10.1021/acs.jmedchem.1c02148
Autor:
Ramulu Poddutoori, Kimberly Aardalen, Kiran Aithal, Sanjeev Surendranath Barahagar, Charamanna Belliappa, Mark Bock, Shekar Chelur, Andrea Gerken, Sreevalsam Gopinath, Bjoern Gruenenfelder, Michael Kiffe, Maithreyi Krishnaswami, John Langowski, Sudharshan Madapa, Kishore Narayanan, Chetan Pandit, Sunil Kumar Panigrahi, Mark Perrone, Ravi Kumar Potakamuri, Murali Ramachandra, Anuradha Ramanathan, Rita Ramos, Emine Sager, Susanta Samajdar, Hosahalli S. Subramanya, Devaraja Seethappa Thimmasandra, Eleni Venetsanakos, Henrik Möbitz
Publikováno v:
Journal of Medicinal Chemistry. 65:4350-4366
Mutations in MEK1/2 have been described as a resistance mechanism to BRAF/MEK inhibitor treatment. We report the discovery of a novel ATP-competitive MEK1/2 inhibitor with efficacy in wildtype (WT) and mutant MEK12 models. Starting from a HTS hit, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df3980bf0fc9797eb2d0401e08b1d0f
https://doi.org/10.1021/acs.jmedchem.1c02192
https://doi.org/10.1021/acs.jmedchem.1c02192
Autor:
Christelle Stamm, Pierre Nimsgern, Thomas Knoepfel, Jasmin Wirth, Michel Niklaus, Diana Graus-Porta, Alberto Del Rio Espinola, Dario Sterker, Michael Kiffe, Nicolas Warin, Van Huy Luu, Mario Madoerin, Robert Mah, Jacqueline Kinyamu-Akunda, Robin Alec Fairhurst, Milen Todorov, Nicole Buschmann, Sebastien Ripoche, Nils Ostermann, Inga Galuba, Philippe Couttet, Catherine Leblanc, Alexandra Buhles, Jutta Blank, Flavia Adler, Wolfgang Jahnke, Chao Zou, Joerg Berghausen, Andreas Weiss, Pascal Furet, Heiko Schadt, Johannes Voshol, Markus Wartmann, Joerg Trappe
Publikováno v:
Journal of Medicinal Chemistry. 63:12542-12573
FGF19 signaling through the FGFR4/β-klotho receptor complex has been shown to be a key driver of growth and survival in a subset of hepatocellular carcinomas, making selective FGFR4 inhibition an attractive treatment opportunity. A kinome-wide seque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e8386d5d1c6ff60ee10d825b90d6de
https://doi.org/10.1021/acs.jmedchem.0c01019
https://doi.org/10.1021/acs.jmedchem.0c01019