Zobrazeno 1 - 10
of 281
pro vyhledávání: '"Michael, Kashgarian"'
Autor:
Dennis G. Moledina, Wassim Obeid, Rex N. Smith, Ivy Rosales, Meghan E. Sise, Gilbert Moeckel, Michael Kashgarian, Michael Kuperman, Kirk N. Campbell, Sean Lefferts, Kristin Meliambro, Markus Bitzer, Mark A. Perazella, Randy L. Luciano, Jordan S. Pober, Lloyd G. Cantley, Robert B. Colvin, F. Perry Wilson, Chirag R. Parikh
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 13 (2023)
Background Acute tubulointerstitial nephritis (AIN) is one of the few causes of acute kidney injury with diagnosis-specific treatment options. However, due to the need to obtain a kidney biopsy for histological confirmation, AIN diagnosis can be dela
Externí odkaz:
https://doaj.org/article/8efe2f2685704f25a2ece87934b2792f
Autor:
Rithy Meas, Joanne Nititham, Kimberly E. Taylor, Stephen Maher, Kaylyn Clairmont, Kelly E. W. Carufe, Michael Kashgarian, Timothy Nottoli, Ana Cheong, Zachary D. Nagel, Patrick M. Gaffney, Lindsey A. Criswell, Joann B. Sweasy
Publikováno v:
ACR Open Rheumatology, Vol 4, Iss 9, Pp 760-770 (2022)
Objective To determine if single‐nucleotide polymorphisms (SNPs) in DNA repair genes are enriched in individuals with systemic lupus erythematosus (SLE) and if they are sufficient to confer a disease phenotype in a mouse model. Methods Human exome
Externí odkaz:
https://doaj.org/article/97dbb8d80fed4e8691a4b02bf4ca46c8
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Vascular endothelial growth factor-a (VEGF-A) and nitric oxide (NO) are essential for glomerular filtration barrier homeostasis, and are dysregulated in diabetic kidney disease (DKD). While NO availability is consistently low in diabetes, both high a
Externí odkaz:
https://doaj.org/article/41ddbebcb869477b9a37fab161a12f88
Autor:
Hannah Melchinger, Frida Calderon-Gutierrez, Wassim Obeid, Leyuan Xu, Melissa M. Shaw, Randy L. Luciano, Michael Kuperman, Gilbert W. Moeckel, Michael Kashgarian, F. Perry Wilson, Chirag R. Parikh, Dennis G. Moledina
Publikováno v:
Clinical Journal of the American Society of Nephrology. 17:1284-1292
Uromodulin, produced exclusively in the kidney's thick ascending limb, is a biomarker of kidney tubular health. However, the relationship between urine uromodulin and histologic changes in the kidney tubulointerstitium has not been characterized. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29ad99f23a0b03b2e31eb22b26caee3
https://doi.org/10.2215/cjn.04360422
https://doi.org/10.2215/cjn.04360422
Publikováno v:
Dermatopathology, Vol 3, Iss 2, Pp 55-60 (2016)
The virus, which causes orf and induces acute pustular skin lesions in sheep and goats, is transmissible to humans yet is rarely observed in North America. We present a case of a 65-year-old female farmer from Connecticut who contracted orf from her
Externí odkaz:
https://doaj.org/article/bb640948ca354cd1bbf9b8f0d55a2a5c
Autor:
Mallika Ghosh, Shobha Thangada, Oisharya Dasgupta, Kamal M Khanna, Harold T Yamase, Michael Kashgarian, Timothy Hla, Linda H Shapiro, Fernando A Ferrer
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194053 (2018)
Sphingosine Kinase-2 (Sphk2) is responsible for the production of the bioactive lipid Sphingosine-1 Phosphate, a key regulator of tissue repair. Here we address the in vivo significance of Sphingosine Kinase -2 in renal inflammation/fibrosis in respo
Externí odkaz:
https://doaj.org/article/42d52938e5744f6c81a303150b339e7f
Autor:
Alireza G. Senejani, Yanfeng Liu, Dawit Kidane, Stephen E. Maher, Caroline J. Zeiss, Hong-Jae Park, Michael Kashgarian, Jennifer M. McNiff, Daniel Zelterman, Alfred L.M. Bothwell, Joann B. Sweasy
Publikováno v:
Cell Reports, Vol 6, Iss 1, Pp 1-8 (2014)
A replication study of a previous genome-wide association study (GWAS) suggested that a SNP linked to the POLB gene is associated with systemic lupus erythematosus (SLE). This SNP is correlated with decreased expression of Pol β, a key enzyme in the
Externí odkaz:
https://doaj.org/article/d60217a0e3fe4edaa2240b7b757d30f8
Autor:
Lidiya Kukova, Michael Kashgarian, Dennis G. Moledina, Gilbert W. Moeckel, Wassim Obeid, Michael Kuperman, Chirag R. Parikh, Randy L. Luciano, Lloyd G. Cantley, Mark A. Perazella, F. Perry Wilson
Publikováno v:
Nephrol Dial Transplant
Background We previously demonstrated that urine interleukin (IL)-9 and tumor necrosis factor (TNF)-α can distinguish acute interstitial nephritis (AIN) from other causes of acute kidney injury. Here we evaluated the role of these biomarkers to prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70c05f423b37c134fee86deee730c35
https://doi.org/10.1093/ndt/gfaa169
https://doi.org/10.1093/ndt/gfaa169
Autor:
Shinu John, Mark J. Shlomchik, Jeremy S. Tilstra, Michael Kashgarian, Claire Leibler, Kevin M. Nickerson, Rachael A. Gordon, Sheldon I. Bastacky
Publikováno v:
J Clin Invest
Toll-like receptor 9 (TLR9) is a regulator of disease pathogenesis in systemic lupus erythematosus (SLE). Why TLR9 represses disease while TLR7 and MyD88 have the opposite effect remains undefined. To begin to address this question, we created 2 alle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b183ce1b87b1aabe744e8a7c520fe92b
https://doi.org/10.1172/jci132328
https://doi.org/10.1172/jci132328
Autor:
Delma, Veron, Pardeep K, Aggarwal, Qi, Li, Gilbert, Moeckel, Michael, Kashgarian, Alda, Tufro
Publikováno v:
Frontiers in pharmacology. 12
Vascular endothelial growth factor-a (VEGF-A) and nitric oxide (NO) are essential for glomerular filtration barrier homeostasis, and are dysregulated in diabetic kidney disease (DKD). While NO availability is consistently low in diabetes, both high a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8cfdf182d13b3755c6616de68be14fa8
https://pubmed.ncbi.nlm.nih.gov/35280251
https://pubmed.ncbi.nlm.nih.gov/35280251