Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Michael, K Trower"'
Autor:
Michael K. Trower, Huda Badri, Jaclyn A. Smith, David Allman, Robert F. Miller, Imran Satia, Andrew Wood, Julie Morris
Publikováno v:
Chest. 157:111-118
Background Substance P and the neurokinin-1 (NK-1) receptor are implicated in chronic refractory cough pathophysiology. We assessed the efficacy and safety of orvepitant, a brain-penetrant NK-1 antagonist, in an open-label study in CRC patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d89b7a550b24713bc9a2272feefa9a18
https://doi.org/10.1016/j.chest.2019.08.001
https://doi.org/10.1016/j.chest.2019.08.001
Publikováno v:
BioTechniques, Vol 20, Iss 3, Pp 372-374 (1996)
Externí odkaz:
https://doaj.org/article/c5161948c9184f71ad600a0978cd24ec
Autor:
Mandel Sher, Lorcan McGarvey, Mary Kerr, Stephen Pawsey, Michael K. Trower, Alyn H. Morice, Jaclyn A. Smith, Elizabeth Ballantyne
Publikováno v:
Clinical Problems.
Background: No proven therapies exist for refractory chronic cough (CC). Neurokinin(NK)-1 antagonists may modulate the central neural hypersensitivity causing CC. The NK-1 antagonist orvepitant was assessed in CC in a Phase 2b dose-ranging study. Met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0af188f58d97752d57ceae66afc24593
https://doi.org/10.1183/13993003.congress-2019.pa600
https://doi.org/10.1183/13993003.congress-2019.pa600
Autor:
Jaclyn, Smith, David, Allman, Huda, Badri, Robert, Miller, Julie, Morris, Imran, Satia, Andrew, Wood, Michael, K Trower
Publikováno v:
Chest. 157(1)
Substance P and the neurokinin-1 (NK-1) receptor are implicated in chronic refractory cough pathophysiology. We assessed the efficacy and safety of orvepitant, a brain-penetrant NK-1 antagonist, in an open-label study in CRC patients with chronic ref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7b276d4bf7eedd14f284c5883b112b8f
https://pubmed.ncbi.nlm.nih.gov/31421110
https://pubmed.ncbi.nlm.nih.gov/31421110
Autor:
Steven Edward Buchholz, Fateme Sima Sariaslani, Michael K. Trower, R. Lenstra, Charles A. Omer
Publikováno v:
Molecular Microbiology. 6:2125-2134
Summary Xenobiotic transformation by Streptomyces griseus (ATCC13273) is catalysed by a cytochrome P-450, designated cytochrome P-450soy A DNA segment carrying the structural gene encoding P-450soy (soyC) was cloned using an oligonucleotide probe con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61093e73a4312cf6f25a66b352a6eb1c
https://doi.org/10.1111/j.1365-2958.1992.tb01386.x
https://doi.org/10.1111/j.1365-2958.1992.tb01386.x
Publikováno v:
Biochemical and Biophysical Research Communications. 170:456-461
Oxidation of (+) camphor by cytochrome P-450soy-enriched intact cells of Streptomyces griseus resulted in the formation of one major and several minor metabolites. The minor metabolites were identified as 3-endo-hydroxycamphor (2%), 5-endo-hydroxycam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c1b49ff8272175cc551727a48afb74
https://doi.org/10.1016/0006-291x(90)92113-e
https://doi.org/10.1016/0006-291x(90)92113-e
