Zobrazeno 1 - 10
of 267
pro vyhledávání: '"Michael, Houghton"'
Autor:
Vanessa Meier-Stephenson, Michael T. Hawkes, Catherine Burton, Ainslie Calcutt, Chris Davis, Jessica Dooley, Michael Good, Michael Houghton, Eloise Keeffe, Kelly Kim, Ailin Lepletier, Conar O’Neil, Ijeoma Ogbuehi, Victoria Ozberk, Manisha Pandey, Simone Reynolds, Avi Seth, William Stokes, Alena Tse-Chang, Ben Tyrrell, D. Lorne Tyrrell, Gregory J. Tyrrell, Maryna Yaskina
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract Background Group A streptococci (Strep A) orStreptococcus pyogenes is a major human pathogen causing an estimated 500,000 deaths worldwide each year. Disease can range from mild pharyngitis to more severe infections, such as necrotizing fasc
Externí odkaz:
https://doaj.org/article/3b507af6859c43d3b742a62462d6dfde
Autor:
Maral Aminpour, Williams Ernesto Miranda Delgado, Soren Wacker, Sergey Noskov, Michael Houghton, D. Lorne J. Tyrrell, Jack A. Tuszynski
Publikováno v:
BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-20 (2021)
Abstract Background The emergence and rapid spread of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) in thelate 2019 has caused a devastating global pandemic of the severe pneumonia-like disease coronavirus disease 2019 (COVID-19). Alth
Externí odkaz:
https://doaj.org/article/950a279162d149fe991a7933805bb00a
Autor:
Faisal Hossain, Qiming Shen, Nicholas Balasuriya, John Lok Man Law, Michael Logan, Michael Houghton, D. Lorne Tyrrell, Michael A. Joyce, Michael J. Serpe
Publikováno v:
Analytical Chemistry. 95:7620-7629
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::212d44019ac48bf289b59983b74ba579
https://doi.org/10.1021/acs.analchem.3c00481
https://doi.org/10.1021/acs.analchem.3c00481
Autor:
Deanna M Santer, Gillian E S Minty, Dominic P Golec, Julia Lu, Julia May, Afshin Namdar, Juhi Shah, Shokrollah Elahi, David Proud, Michael Joyce, D Lorne Tyrrell, Michael Houghton
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008515 (2020)
Type III interferons (IFN-lambdas(λ)) are important cytokines that inhibit viruses and modulate immune responses by acting through a unique IFN-λR1/IL-10RB heterodimeric receptor. Until now, the primary antiviral function of IFN-λs has been propos
Externí odkaz:
https://doaj.org/article/9cef71d5d96e4ee7ace8f108f9ac10b6
Autor:
Mohammed A. Sarhan, Mohamed S. Abdel-Hakeem, Andrew L. Mason, D. Lorne Tyrrell, Michael Houghton
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Direct acting antivirals against hepatitis C virus (HCV) have markedly improved cure rates in the past few years. However, they are expensive, with only few targeting host cell factors, and affecting virus assembly and release. Huh7.5 cells
Externí odkaz:
https://doaj.org/article/f51753bd6d524097863f80264b9246e4
Circadian rhythms play a key role in maintaining metabolic activities. Behavioural factors, such as jet lag, shift work and meal timing disrupt circadian rhythms, which have been associated with an increased risk of developing metabolic syndrome. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ad9fab3babb320baf95c540f98e40eb
Autor:
William Ledoux PhD, John Anderson MD, Donald Bohay MD, FACS, J. Chris Coetzee MD, James Davitt MD, Sigvard Hansen MD, Michael Houghton MD, Mike Orendurff PhD, Jane Shofer MS, Dan Norvell PhD, Bruce Sangeorzan MD
Publikováno v:
Foot & Ankle Orthopaedics, Vol 3 (2018)
Category: Ankle Arthritis Introduction/Purpose: We used step counts as objective measures of activity as a compliment to patient self-reported outcomes in treatment of ankle arthritis to validate success or failure of treatment. Methods: 234 patients
Externí odkaz:
https://doaj.org/article/76e635aee112462cbb7a32e46b1097a3
Autor:
Bruce Sangeorzan MD, J. Chris Coetzee MD, Donald Bohay MD, FACS, John Anderson MD, James Davitt MD, Michael Houghton MD, John Maskill MD, Michael Brage MD, Daniel Norvell PhD, Jane Shofer MS, William Ledoux PhD
Publikováno v:
Foot & Ankle Orthopaedics, Vol 3 (2018)
Category: Ankle Arthritis Introduction/Purpose: Patients seeking surgical treatment for ESAA have two primary treatment options: arthrodesis and arthroplasty. While there are comparative trials that address treatment options, neither the complication
Externí odkaz:
https://doaj.org/article/51d5642a385a41e1bd18cfa36d536e9d
Autor:
Tapan Kanai, Zongyi Hu, Renbin Yang, Weimin Wu, Ziqiu Wang, Christopher D. Ma, Jaime Sanchez-Meza, Mansun Law, Michael Houghton, John Lokman Law, Michael Logan, Natalia de Val, T. Jake Liang
Publikováno v:
J Virol
Despite the development of highly effective hepatitis C virus (HCV) treatments, an effective prophylactic vaccine is still lacking. HCV infection is mediated by its envelope glycoproteins, E1 and E2, during the entry process, with E2 binding to cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b0adc409d8266a8115689f17963387
https://europepmc.org/articles/PMC9888182/
https://europepmc.org/articles/PMC9888182/
Autor:
Kanti Pabbaraju, Matthew A. Croxen, Holly A. Saffran, Kevin Crawford, Michael Logan, Gerald LaChance, Darren Hockman, John Lok Man Law, D. Lorne Tyrrell, Abdolamir Landi, Janelle Johnson, Graham Tipples, Raelynn Brassard, Justin Shields, Eve Hobart, Michael Houghton, M. Joanne Lemieux, Michael A. Joyce, Elena Arutyunova
Publikováno v:
Vaccine
SARS-CoV-2 is the etiological agent of COVID19. There are currently several licensed vaccines approved for human use and most of them are targeting the spike protein (or virion) in the virion envelope to induce protective immunity. Recently, variants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e103c5c330664243455b4cc9fc1daec9
https://doi.org/10.1016/j.vaccine.2021.08.081
https://doi.org/10.1016/j.vaccine.2021.08.081